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A genetic analysis of COVID-19 patients suggests that blood type might influence whether someone develops severe disease.Scientists who compared the genes of thousands of patients in Europe found that those who had Type A blood were more likely to have severe disease while those with Type O were less likely.Wednesday’s report in the New England Journal of Medicine does not prove a blood type connection, but it does confirm a previous report from China of such a link.“Most of us discounted it because it was a very crude study,” Dr. Parameswar Hari, a blood specialist at the Medical College of Wisconsin, said of the report from China. With the new work, “now I believe it,” he said. “It could be very important.”Other scientists urged caution.The evidence of a role for blood type is “tentative ... it isn’t enough of a signal to be sure,” said Dr. Eric Topol, head of the Scripps Research Translational Institute in San Diego.The study, involving scientists in Italy, Spain, Denmark, Germany and other countries, compared about 2,000 patients with severe COVID-19 to several thousand other people who were healthy or who had only mild or no symptoms. Researchers tied variations in six genes to the likelihood of severe disease, including some that could have a role in how vulnerable people are to the virus. They also tied blood groups to possible risk.Most genetic studies like this are much larger, so it would be important to see if other scientists can look at other groups of patients to see if they find the same links, Topol said.Many researchers have been hunting for clues as to why some people infected with the coronavirus get very ill and others, less so. Being older or male seems to increase risk, and scientists have been looking at genes as another possible “host factor” that influences disease severity.There are four main blood types — A, B, AB and O — and “it’s determined by proteins on the surface of your red blood cells,” said Dr. Mary Horowitz, scientific chief at the Center for International Blood and Marrow Transplant Research.People with Type O are better able to recognize certain proteins as foreign, and that may extend to proteins on virus surfaces, Hari explained.During the SARS outbreak, which was caused by a genetic cousin of the coronavirus causing the current pandemic, “it was noted that people with O blood type were less likely to get severe disease,” he said.Blood type also has been tied to susceptibility to some other infectious diseases, including cholera, recurrent urinary tract infections from E. coli, and a bug called H. pylori that can cause ulcers and stomach cancer, said Dr. David Valle, director of the Institute of Genetic Medicine at Johns Hopkins University.Bottom line: “It’s a provocative study. It’s in my view well worth publishing and getting out there,” but it needs verification in more patients, Valle said.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 3086
A day after Republicans attempted to portray the Democratic Party's platform as "far-left socialism," the Trump campaign will attempt to continue that messaging during the second night of speeches at the Republican National Convention.On Monday, speakers attempted to paint Democratic presidential nominee Joe Biden as part of the party's left-wing, despite his moderate record. Speakers warned of progressive Democrats' calls to defund police departments and institute gun control measures.Tuesday's program will attempt to further those talking points. According to the Trump Campaign website, the second day of the RNC will focus on "how Democrats' radical left agenda will deny Americans the opportunity to achieve their full potential."The theme of Tuesday's program is "Land of Opportunity," which includes a focus on the Trump policies that Republicans say "empower" all Americans.Tuesday's slate of speakers is highlighted by Sec. of State Mike Pompeo, one of Trump's fiercest allies. Pompeo's speech will likely focus on Trump's defeat of the Islamic State group, his attempts to normalize relations with North Korea and his attempts to push back against national security threats from China.Pompeo drew criticisms last week for tweeting a Simpsons GIF to mock House Speaker Nancy Pelosi.Also expected to speak is Kentucky Attorney General Daniel Cameron — the man currently in charge of investigating the death of Breonna Taylor a the hands of police in March.Two of Trump's children are also slated to deliver addresses — Eric, his second-oldest son, and Tiffany, his youngest daughter.Below is Tuesday's list of speakers in the order in which they are expected to appear.Pastor Norma Urrabazo, International Church of Las VegasMyron Lizer, Vice President of the Navajo NationRichard Beasley, former FBI special agent an President of Global Intelligence NetworkJon Ponder, founder and CEO of HOPE for Prisoners, Inc.Sen. Rand Paul (R-Kentucky)Jason Joyce, Coast Guard Licensed CaptainCris Peterson, CEO of Minnesota dairy farmLarry Kudlow, Assistant to the President for Economic Policy and Director of the National Economic CouncilJohn Peterson, CEO of President of Schuette MetalsCissie Graham Lynch, granddaughter of televangelist Billy GrahamRobert Vlaisavljevich, mayor of Eveleth, MinnesotaAbby Johnson, pro-life advocate and former Planned Parenthood employeeMary Ann Mendoza, mother of a police officer killed by an undocumented immigrantNicholas Sandmann, Covington Catholic student who sued several media outlets for defamationPam Bondi, former Florida Attorney GeneralTiffany Trump, daughter of President Donald TrumpIowa Gov. Kim ReynoldsRyan Holets, Albuquerque police officer and father to adopted childFlorida Lt. Governor Jeanette Nu?ezEric Trump, son of President Donald TrumpKentucky Attorney General Daniel CameronSec. of State Mike Pompeo 2877

A long line of people stretched down the street and around a corner in Amsterdam, New York, Friday evening as mourners waited to to enter St. Stanislaus Roman Catholic Church.They wanted to honor the lives of eight people -- four of them sisters -- who died in last weekend's devastating limousine crash."Nobody cared how cold it was," said Christopher Carpenter, a resident who attended the gathering and knew one of the victims, Abigail Jackson. "The wind was blowing. It was overcast, and everybody still stayed in that line to go through the church."As they entered, attendees extended their condolences to the families of Abigail and Adam Jackson, Mary and Robert Dyson, Amy and Axel Steenburg, Allison King and Richard Steenburg. And the families greeted each person who came, Carpenter said."It was almost like the family was taking care of us," he said, "and we were taking care of them." 904
A gunman killed 26 people and wounded 20 others at a Texas church Sunday morning in what Gov. Greg Abbott called the largest mass shooting in state history.At one point, the shooter tried to get a license to carry a gun in Texas but was denied by the state, Abbott said, citing the director of Texas' Department of Public Safety."So how was it that he was able to get a gun? By all the facts that we seem to know, he was not supposed to have access to a gun," Abbott told CNN. "So how did this happen?" 510
A Caroline County, Maryland man was arrested after an investigation led to criminal charges of possession and distribution of child pornography.The suspect, Jeffrey Litteral, 52, of Denton, Maryland, has been charged with possession of child pornography, distribution of child pornography, possession of obscene material and distribution of obscene material. Litteral was arrested near his home at around 7:30 p.m. Tuesday night and, from there, he was taken before a court commissioner for an initial appearance and was held without bond.This investigation began in 2017 when a Maryland State Police Criminal Enforcement Division investigator received information about possible child pornography being uploaded to the internet. This led to Litteral and the development of evidence that enabled investigators to obtain an arrest warrant.During the investigation, detectives also learned that Litteral was employed by the United States Secret Service. Officials there assisted during his investigation and arrest.The investigation is continuing, so additional charges are possible. 1114
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