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SAN DIEGO, Calif. – What’s usually a marathon for biotech companies is now a full-blown sprint to stop the spread of coronavirus.Kate Broderick, the Senior Vice President of R&D at Inovio Pharmaceuticals in San Diego, remembers the moment she first learned about the mysterious outbreak unfolding thousands of miles away. “Yes, absolutely, distinctly, probably one of those moments you’ll remember forever. I was in my kitchen at home the 31st of December,” said Broderick.She never imagined that two months later it would be the crisis it is today. “Every week I keep thinking it’s going to get better, it’s going to start to tone down a little bit, but in fact, rather than getting better it’s getting worse every week,” said Broderick.Inovio has made headlines before, creating vaccines for Zika, Ebola, and now the coronavirus. After Chinese researchers shared the genetic sequence of COVID-19, Inovio designed a vaccine in just three hours Using its proprietary DNA medicines platform technology. The vaccine was designed to precisely match the DNA sequence of the virus“In an outbreak setting we really don’t have two to three years to wait for a vaccine, so that’s where we come in at Inovio pharmaceuticals, we use DNA medicine technology,” said Broderick.While traditional vaccines use the virus itself, this method puts DNA inside E.coli, which naturally replicates the medicine over and over. The paste is then purified, leaving behind only the DNA medicine, which Inovio hopes to test in humans next month.“Infectious diseases are global and they don’t care about boundaries and borders, everyone is affected from childhood all the way through seniors,” said Phyllis Arthur, who’s been in the infectious disease industry for 20 years.Arthur is Vice President of Infectious Diseases and Diagnostic Policy at BIO, an association made up of about 1,000 companies.“One of the things we’re seeing, from outbreak to outbreak, unfortunately, is we’re getting faster at using platform technologies to build something that can be tried in humans sooner than we were the last time,” said Arthur.She’s following dozens of companies working on vaccines, treatments, and diagnostic tools. If their vaccines work, companies like Inovio will have to figure out how to manufacture them fast.“You may have the best vaccine in the world, but if you can only produce 1,000 doses of it, that’s not really going to help 1.4 billion people in China,” said Broderick. Continued funding will also be critical. Broderick says while their Zika vaccine looked promising in humans, it never ultimately got FDA approval for broad public use.“The problem there was, although great for global health, was that of course cases of the virus really steadily declined, the problem for us there was so did the funding,” said Broderick.She says that way of thinking is shortsighted but does see change on the horizon. “It’s a huge amount of responsibility on everyone’s shoulders, and I think we feel genuinely compelled to do everything in our power, hence why no one complains about two hours of sleep, because this is a point in our careers we can truly, literally, make a difference in saving lives, right now,” said Broderick.After the company begins human trials in the U.S., they’ll continue testing in China and South Korea. They hope to deliver one million doses by the end of the year.If they make it that far, it too would be a day Broderick will never forget. 3462

TAMPA, Fla — Amy Bottomley was raised in the suburbs of Chicago by two parents who loved her very much — a little girl who grew up and moved with her husband and son to Tampa.She says there’s always been a piece of her heart missing — and on Thursday, in front of Gate C inside Tampa International Airport, she was ready to find that missing piece.Bottomley had spent months talking on the phone with her birth mother, Kathleen Buchanan. They had connected after Bottomley got the results of a DNA test."I am feeling a mix of emotions right now,” Bottomley said as she sat in the seat and waited for her birth mom’s plane to land. “It’s going to be interesting.”Her hands were shaking, her heart was racing. She got a text that her birth mom's plane had landed. She’s been waiting for this moment, "My whole life, my entire life, 42 years.” 852

Supreme Court Justice Ruth Bader Ginsburg was discharged from the hospital on Tuesday and is recuperating at home after undergoing surgery, according to a court spokesperson."Justice Ginsburg was discharged from the hospital yesterday and is recuperating at home," said Kathy Arberg, public information officer for the Supreme Court, in an email to reporters. 371

Some cats may seem a little more aloof than dogs, but they respond to the people they've bonded with in a similar way, according to a new study.Research at Oregon State University has shown that cats can form secure or insecure bonds with their owners. The researchers now believe the trait isn't specific to dogs, as similar research has shown, since it now applies to cats.During human attachment behavior studies, researchers look at how babies respond when they're reunited with their parent or caregiver after a short absence. When they're reunited, securely bonded babies return to exploring their surroundings in a relaxed way. About 65% of babies have a secure attachment. But insecurely attached babies will either avoid their parent or cling to them.The same tests have been simulated with primates as well. After applying it to dogs, babies and primates, the researchers wanted to see what would happen when they added cats and kittens to the scenario.The cats and kittens would individually spend two minutes in a room with their owner or caregiver. Then, the person would leave the room for two minutes, followed by a two minute reunion. This is called a "secure base test."About 65% of the cats and kittens were found to be securely bonded to their owners. Their finding shows that the cats' bonds with people were stable in adulthood, and not just present in kittens.The securely attached cats will continue to explore their surroundings after their owner returned, as well as pay attention to their owner. The insecurely attached cats showed signs of stress, like twitching tails, licking lips, avoiding their owner or jumping in their lap and not moving, which is a sign of ambivalence.A study detailing the findings published Monday in the journal 1778

So is this what our 500 additional transit cops are choosing to pursue? Terrorizing someone who’s just trying to make a living? This is excessive and heartless. https://t.co/1NWiXzyN94— Antonio Reynoso (@CMReynoso34) November 9, 2019 245

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