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WASHINGTON, Jan. 19 (Xinhua) -- New research published this week in Nature Medicine indicates that targeted drugs such as gefitinib might more effectively treat non-small cell lung cancer if they could be combined with agents that block certain microRNAs.The study, led by investigators with the Ohio State University Comprehensive Cancer Center, shows that overexpression of two genes called MET and EGFR causes the deregulation of six microRNAs, and that this deregulation leads to gefitinib resistance.The findings support the development of agents that restore the levels of these microRNAs. It offers a new strategy for treating non-small cell lung cancer, which is responsible for about 85 percent of the 221,000 lung-cancer cases and 157,000 deaths that occur annually in the United States. It also suggests that measuring the expression levels of certain microRNAs -- those controlled by the MET gene -- might predict which lung-cancer cases are likely to be resistant to gefitinib.Epidermal growth factor receptor (EGFR) is frequently overexpressed in non-small cell lung cancer, and this leads to uncontrolled cell proliferation. Gefitinib selectively inhibits EGFR activation and triggers cancer cells to self-destruct by apoptosis. However, non-small cell lung cancer cells inevitably develop resistance to the drug. The study reveals how this resistance occurs."Our findings suggest that gefitinib resistance that is caused by MET overexpression is at least partly due to miRNA deregulation, " says principal investigator Carlo Croce.

WASHINGTON, Oct. 18 (Xinhua) -- Scientists have increased the estimate of the number of humpback whales in the North Pacific Ocean, according to a paper published Tuesday in the Marine Mammal Science journal.The increase follows a refined statistical analysis of data compiled in 2008 from the largest whale survey ever carried out to appraise humpback whale populations throughout the North Pacific.The number of North Pacific humpback whales in the 2008 study, known as the Structure of Populations, Levels of Abundance and Status of Humpbacks, or SPLASH, was estimated at just under 20,000 based on a preliminary look at the data.The latest research indicates the population to be over 21,000 and possibly even higher -- a significant improvement to the scant 1,400 humpback whales estimated in the North Pacific Ocean at the end of commercial whaling in 1966."These improved numbers are encouraging, especially after we have reduced most of the biases inherent in any statistical model," said Jay Barlow, marine mammal biologist of the U.S. National Oceanic and Atmospheric Administration (NOAA)."We feel the numbers may even be larger since there have been across-the-board increases in known population areas and unknown areas have probably seen the same increases," Barlow added.The SPLASH research was a three-year project started in 2004 involving NOAA scientists and hundreds of other researchers from the United States, Japan, Russia and some other countries.It was the first systematic survey ever attempted to determine the humpback whales' overall population, structure and genetic makeup in the North Pacific.

JERUSALEM, Nov. 1 (Xinhua) -- Israeli researchers at Tel Aviv University developed a computer chip that could recuperate loss body movement if placed in the cerebellum, opening the doors to treatment of brain damage, researchers told Xinhua on Tuesday.The computer chip, wired to a man-made segment of a cerebellum, was attached to a rodent's skull that had lost the ability to blink. After the artificial cerebellum was implanted, the rodent was once again able to blink.The chip, connected to the rat's brain, works by reading sensory information from the body and then communicating it to the cerebellum, the area of the brain that allows movement coordination, through electrodes."The chip itself imitates a small part of the cerebellum, a very tiny part of it," said Prof. Matti Mintz of TAU's Department of Psychology."We took a small part of the cerebellum and studied it and created the computer chip that mimics the damaged area," he said.However, more complicated movements, like walking, are still at least one decade away, Mintz added."We still did not test it on humans because we need to know the area the chip will mimic before installing it, which requires extensive research. But we are now developing a chip that will do a sequence of simple movements," he pointed out.When fully developed for humans, it can be used to help patients who suffer brain genetic diseases like Parkinson, or had strokes that caused brain damage.

BEIJING, Jan. 3 (Xinhua) -- A collection of China's nine white papers issued in 2011 has been published in both Chinese and English, according to a statement issued by the publisher on Tuesday.By giving a clear and precise illustration of China's policies, principles and progress in subjects like national defense, law, climate change and international trade, the white papers can help the world know about, and understand, China, the statement said.The white papers are titled, "China's National Defense in 2010," "China's Foreign Aid," "Sixty Years Since the Peaceful Liberation of Tibet," "China's Peaceful Development," "The Socialist System of Laws with Chinese Characteristics," "New Progress in Development-oriented Poverty Reduction Program for Rural China," "China's Policies and Actions for Addressing Climate Change (2011)," "China's Foreign Trade" and "China's Space Activities in 2011."The white papers were all published by the Information Office of the State Council on behalf of the Chinese government.The latest one on space activities was issued last Thursday.

CANNES, France, Nov. 3 (Xinhua) -- Chinese President Hu Jintao on Thursday urged the world's major economies to work together to promote growth and financial stability."It is imperative that we stand on a higher plane, transcend differences on specific issues, move beyond short-term considerations, and jointly seek ways to overcome the crisis and sustain development," Hu told the Group of 20 (G20) summit here."At this critical moment, the G20 must work to address the key problems, boost market confidence, defuse risks and meet challenges and promote global economic growth and financial stability," said Hu.As the premier forum for international economic cooperation, the G20 must continue to demonstrate the spirit of standing together in times of adversity and pursuing win-win cooperation, he said.The Chinese president said "the current world economic situation deserves our high attention," cautioning the global recovery is fraught with instability and uncertainty and faces growing risks and challenges.Some major economies are experiencing economic slowdown and some countries are facing acute sovereign debt problems, said Hu.He also cited volatility in the international financial markets, and high inflationary pressure in emerging markets.Hu put forward a five-point proposal on what G20 nations need to do to tide over the crisis.First, the countries should ensure growth while paying attention to balance. Given the serious risks facing the global economy and continued market volatility, ensuring growth and promoting stability should be the top priority, he said."We should introduce new and strong measures to ensure that fiscal and monetary policies are fully implemented and that funding is channeled into the real economy to boost production and employment."Second, the G20 nations should strengthen unity and send a strong signal to the world as there is widespread panic and acute lack of confidence in the markets, said Hu.He urged G20 members to strengthen consultation and coordination, tackle sovereign debt risks, regulate cross-border capital flow, put the fluctuation of commodity prices under control, mitigate global inflationary pressure and make sure that the economic policies pursued by various countries do not offset each other.Third, global economic governance should be improved through reform, Hu said.The international financial crisis has highlighted the deficiencies in the global economic governance system, said Hu."Major efforts should be made to reform and improve the international monetary system, international trading system and commodity pricing mechanism," said the Chinese president.

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