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While scientists work to come up with a safe and effective COVID-19 vaccine, doctors across the country are watching closely. Many are helping guide their patients in making an informed decision about getting a vaccine."This was indeed a surprise to see that there would vaccines available by the 1st of November. It’s clearly an aspirational goal, because we all would like to see a safe and effective COVID-19 vaccine as soon as possible, but I think testing vaccines to make sure they’re safe and effective is of paramount importance," said Dr. Bali Pulendran, a microbiology and immunology professor at Stanford University.Dr. Pulendran says the process of developing a vaccine involves numerous steps, and scientists are getting closer to the end. Still, it's hard to put an end date on the third and final phase of a vaccine trial. This last phase determines whether the vaccine actually works."The way in which you can assess whether a vaccine works is to see how many of these people acquire the disease or become infected with COVID at some period of time," explained Dr. Pulendran.Phase three divides the trial participants into two groups. One group is given the vaccine, and the other is given a placebo."And then, you calculate the efficacy based on those numbers. So, if there were 200 people affected in the placebo group but there were only 100 people who were infected in the vaccinated group, then the efficacy is 50 percent" said Dr. Pulendran.The third phase is hard to time, as it depends on how quickly some of the trial participants become infected. If they live in areas where COVID-19 infection rates are higher, the phase will be completed faster.But there are some other ways to speed up the vaccine trial.Dr. Darria Long, an emergency room physician and clinical assistant professor at the University of Tennessee-Erlanger, says one way is by doing two of the phases at the same time. Another way is if officials prepare for the manufacturing and logistics side of producing the vaccine during the third phase of the trial."This is what we see the CDC saying is to get ready on the manufacturing and logistics side because even if you come up with the perfect target drug, making sure you can manufacture hundreds of millions and that you have the little glass vials that can keep it at the right temperature, those are all things that can be hang-ups,” said Dr. Long. “So, they're wanting to expedite that process, because the last thing you want is to say is we have the vaccine, but we can’t get it to people.”Dr. Long is already answering her patients' questions as news of a possible COVID-19 vaccine continues to be publicized."I do think a lot of people are wondering about this vaccine and it runs the gamut. There are those that say they really want the vaccine because they see it as this gateway to getting back to life as we know it," said Dr. Long.There are also those who are really concerned about the efficacy and safety of a COVID-19 vaccine. Doctors say a key piece in evaluating a vaccine when it does come out is the data surrounding it."The data that comes out in the public domain: is a particular vaccine efficacious? How effective is it what is the efficacy data? Is a particular vaccine safe? What are the side reactions? And they should talk with their physicians to ask each question. Ask doctors, ‘Could you tell me what the safety part of this vaccine is?" recommended Dr. Pulendran.And above all, doctors and scientists hope politics will stay out of the development of a COVID-19 vaccine in order to ease any concerns or hopes for a vaccine to be available as soon as possible. 3644

With election day looming, the candidates vying to replace Duncan Hunter in East County's 50th Congressional District say they are leaving no stone uncovered.The race is pitting Republican Darrell Issa against Democrat Ammar Campa-Najjar. The two want to fill the seat Hunter vacated in January, when he resigned after pleading guilty to one felony campaign fraud charge. Campa-Najjar narrowly lost to a then-indicted Hunter in 2018 and is running again in 2020."The whole district, we're just going to be traveling across town, meeting people at local diners and saying 'hey, I'm here for you,'" Campa-Najjar said Monday. Issa represented coastal North County's 49th for nearly two decades. In 2018, he decided not to run for re-election as that district shifted blue. This year, however, Issa launched a campaign for the seat in the 50th after Hunter resigned. The district comprises much of East County, and stretches into south Riverside County. It is the only district in San Diego County in which Republicans outnumber Democrats. Issa said his campaign made 10,000 calls Sunday and knocked on more than 1,500 doors. He said if he is elected to Congress, he'd use his experience to help move the country forward. "Many of my Republican and Democratic friends are coming back after two years of very little progress and a lot of hostility," he said. "I'm hoping to get past that with people I have a working relationship with and get some things done."After months of polling showing the two neck-and-neck, an Oct. 27 ABC-10 Union-Tribune poll showed Issa with an 11 point lead over Campa-Najjar. Thad Kousser, a political scientist at UC San Diego, said, however, that Tuesday's early results could show Campa-Najjar starting in the lead due to increasingly Democratic early voting."Things are going to look good for Ammar Campa-Najjar by 8:05, 8:15, the next set of returns that come in are going to be the ones between 9 and 10:30 that will come from polling places," he said. noting that could be as much as a 10 or 15 point swing for Issa, until the rest of the balance come in. 2096

Who will be drafted first overall in Wednesday's NBA Draft?There isn't a consensus No. 1 pick this year because the coronavirus pandemic upended March Madness. Hence, college basketball players could not make any impression or allow NBA teams to evaluate players.The draft typically occurs in June, but the league changed it multiple times before officials decided to do it virtually due to the pandemic.Commissioner Adam Silver, along with Deputy Commissioner Mark Tatum, will announce the selections live at ESPN's headquarters in Bristol, Connecticut.ESPN will have live cameras set to look into 17 team draft rooms, USA Today reported.The first overall pick belongs to the Minnesota Timberwolves, and it's projected that they'll take LaMelo Ball. Still, he could also go No. 2 to Golden State Warriors or No. 3 to Charlotte Hornets.According to ESPN, other top prospects in this year's draft are Georgia guard Anthony Edwards and Memphis center James Wiseman. Here is a complete list of the draft order for round one:1. Minnesota 2. Golden State 3. Charlotte 4. Chicago Bulls5. Cleveland Cavaliers6. Atlanta Hawks7. Detroit Pistons8. New York Knicks9. Washington Wizards10. Phoenix Suns11. San Antonio Spurs12. Sacramento Kings13. New Orleans Pelicans14. Boston Celtics15. Orlando Magic16. Portland Trail Blazers17. Minnesota Timberwolves18. Dallas Mavericks19. Brooklyn Nets20. Miami Heat21. Philadelphia 76ers22. Denver Nuggets23. Utah Jazz24. Milwaukee Bucks25. Oklahoma City Thunder26. Boston Celtics27. New York Knicks28. Oklahoma City Thunder* (Los Angeles Lakers traded 28th pick in exchange for a trade involving OKC's Dennis Schr?der)29. Toronto Raptors30. Boston CelticsThe pre-draft coverage on ESPN will begin at 7:30 p.m. ET, followed by the draft at 8 p.m. ET. 1786

When police in Winfield, Kansas, pulled Rudy Samuel over, the 31-year-old felt he had done nothing wrong. So he started recording the encounter on Facebook Live."Officer says I failed to put my signal light on within a hundred feet," he says to the camera. "And it wasn't a hundred feet, but whatever."The video, shot on May 13, begins after Samuel provides Winfield police officers with his license and registration.When the two policemen approach Samuel's car again, they offer a different reason for the traffic stop."Hey Mr. Samuel, what caught my attention was this vegetation stuff right here," one of them says, pulling something from the seal of the car's driver's-side window. 693

White House chief of staff Mark Meadows told reporters Wednesday that President Donald Trump wants to continue working from the Oval Office despite being infected with COVID-19.According to CNN and CBS, Meadows told reporters that the White House would be taking extra precautions to allow Trump to do so. According to CBS reporter Ben Tracy, any White House staff coming in contact with the president will wear gowns, gloves, masks and eye protection.It's unclear if Trump would also wear personal protective equipment (PPE) while working in the Oval Office.Following Meadows' statement to reporters, Larry Kudlow, the Director of the United States National Economic Council, said during an appearance on CNBC that Trump visited the West Wing with those added precautions on Tuesday.Medical experts say that while PPE greatly reduces the spread of COVID-19, it cannot prevent the spread of the virus entirely. The CDC recommends that anyone who comes within six feet of a person who may have COVID-19 should quarantine for 14 days, excluding those who have had the virus within the last three months.During a press conference on Monday, White House physician Dr. Sean Conley did not specify if Trump would be asked to quarantine in the White House residence while he was infected with COVID-19.This story is breaking and will be updated. 1346

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