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In an unexpected reversal, pharmaceutical giant Biogen said it will pursue US Food and Drug Administration approval for aducanumab, an experimental treatment for early Alzheimer's disease, 201

It was a long year for the Virginia Cavaliers after becoming the first No. 1 seed ever to lose in the first round of the NCAA Tournament. The 2018 loss proved to Virginia that you cannot take anything for granted. Fast forward to 2019, Virginia was back in the NCAA Tournament again as a No. 1 seed. This time, Virginia took care of business. Virginia won in its first ever National Championship appearance, defeating No. 3 seed Texas Tech of the Big 12 Conference, winning by a 85-77 margin in overtime.Virginia was powered by an 11-0 run in overtime. Virginia hit all 12 of its free throws in overtime. The loss to UMBC in 2018 was on everyone's mind throughout this March Madness."Heard about it a lot, and we knew that," Virginia coach Tony Bennett said. "I feel like I repeat myself too much. In a way, it's a painful gift. It did draw us nearer to each other as a team. I think it helped us as coaches. I think it helped the players on the court and helped us in the other areas that rely on things that were significant."I think that karmic payback, I don't know. I knew it was going to be a significant year in all of our lives. I knew that going into this year because of what was going to be coming at us because of that from a basketball standpoint. So I just knew we needed each other."Virginia nearly repeated history, as it trailed by 14 in the first round of its tournament opener three weeks ago. Then Virginia nearly got knocked out of the tournament in the Elite 8 against Purdue on March 30, but a late comeback gave Virginia an overtime win. And on Saturday, Virginia converted on a controversial call to defeat Auburn by one to advance to Monday's title game. This Virginia team continued to persevere.On Monday, Virginia had a 32-29 lead at halftime, and would lead by as much as nine in the second half. Texas Tech went on a 7-0 run to tie the game at 59-all with 3:58 left. After trading free throws, Virginia led 65-61. But a huge by Texas Tech helped spark a 7-0 run. But with the game tied at 68, Texas Tech's Jarrett Culver had his shot blocked at the end of regulation, forcing overtime. 2129

Just woke up and immediately made the impulsive decision to subscribe to arby's limited run subscription box— Year of the Calvin (@Cals_Calzones) January 8, 2019 173

L Brands, the parent company of a number of retail clothing stores, says it plans to close 53 Victoria's Secret stores in 2019.The company has not said which stores it plans to close.According to 208

John Sherer is the organist and director of music at Fourth Presbyterian Church in Chicago, Illinois. “Being a musician is a true calling, because through music you can touch people, you can heal people, you can connect to people in a much, much deeper way, than just through words,” he says. Sherer believes music has a way of binding people together. “Hearing a pipe organ connects you to the universe in a primal way, in a very profound way,” he says.People who walk into the church as he’s playing, say the impact is immediate.“I feel like it’s amazing and magnificent," says a child walking into the church. "I feel like God is right here and is right next to me."Sherer discovered his calling to be a musician early in life, and he’s a big reason why a very special organ in Chicago exists today.“This is the largest pipe organ in Chicago, with well over 8,000 pipes,” Sherer explains. “You’ve heard the phrase ‘pulling out all the stops’, well this is where it really comes from. You pull out all the stops, you’re going all the way, you’re going to get a big, big sound.” The creation of pipe organ took 10 years. Designed by John Michael Quimby, a consultant from New York, the instrument was completed in 2016.“It’s really like having a whole orchestra right under your fingertips," he says. "You’ve got English horn and French horn and flutes and strings and trumpets and trombones, and no two organs are alike.”It takes your entire body to play the instrument, and the intricate details are what make each organ one-of-a-kind. It also provides a full spectrum of sound. “Mozart himself said it was the king of instruments.”The organ is capable of the lowest frequencies any instrument can make, and the highest frequencies any human ear can hear.“The smaller the pipe, the higher the sound. That is the highest note in the organ, so that pipe’s about the sound of my little finger,” he says.To appreciate the instrumental wonder, you have to go inside.“The organ starts in the basement where the blower is located," Sherer says. "The air from the blower goes through massive tubes up to the pipes, and the pipes go all the way up to the ceiling. It’s like being in a tree house at this point, because you’re surrounded by so many different sections of the organ.”Sherer says the pipes are located in the front of the church, in the back of the church and on the sides of the church. The whole building becomes part of the instrument from basement to ceiling, front to back and side to side.The pipes in the back help create a surround sound so everyone can feel connected to the music. The finished product is a beautiful amalgamation of sight and sound.“When people walk into Fourth Presbyterian Church, their eyes make them go ‘ahhhh’ and when they hear the organ, their ears make them go ‘ooooh.’”Sherer explains it as an out-of-body experience as you’re aware of the whole space around you. “I hope that when people hear this organ, they feel comfort and healing, and that they are inspired and lifted up," he says. "And I hope that when they experience the sound of this organ, they realize that there’s something in the universe that’s larger than them.” 3184

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