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A pinch in the leg, a squeal and a trickle of tears. One baby after another in Malawi is getting the first and only vaccine against malaria, one of history’s deadliest and most stubborn of diseases.The southern African nation is rolling out the shots in an unusual pilot program along with Kenya and Ghana. Unlike established vaccines that offer near-complete protection, this new one is only about 40% effective. But experts say it’s worth a try as progress against malaria stalls: Resistance to treatment is growing and the global drop in cases has leveled off. With the vaccine, the hope is to help small children through the most dangerous period of their lives. Spread by mosquito bites, malaria kills more than 400,000 people every year, two-thirds of them under 5 and most in Africa.Seven-month-old Charity Nangware received a shot on a rainy December day at a health clinic in the town of Migowi. She watched curiously as the needle slid into her thigh, then twisted up her face with a howl.“I’m very excited about this,” said her mother, Esther Gonjani, who herself gets malaria’s aches, chills and fever at least once a year and loses a week of field work when one of her children is ill. “They explained it wasn’t perfect, but I feel secure it will relieve the pain.”There is little escaping malaria -- “malungo” in the local Chichewa language -- especially during the five-month rainy season. Stagnant puddles, where mosquitoes breed, surround the homes of brick and thatch and line the dirt roads through tea plantations or fields of maize and sugar cane. In the village of Tomali, the nearest health clinic is a two-hour bike ride away. The longer it takes to get care, the more dangerous malaria can be. Teams from the clinic offer basic medical care during visits once or twice a month, bringing the malaria shot and other vaccines in portable coolers. Treating malaria takes up a good portion of their time during the rainy season, according to Daisy Chikonde, a local health worker.“If this vaccine works, it will reduce the burden,” she said.Resident Doriga Ephrem proudly said her 5-month-old daughter, Grace, didn’t cry when she got the malaria shot.When she heard about the vaccine, Ephrem said her first thought was “protection is here.” Health workers explained, however, that the vaccine is not meant to replace antimalarial drugs or the insecticide-treated bed net she unfolds every night as the sun sets and mosquitoes rise from the shadows. “We even take our evening meals inside the net to avoid mosquitoes,” she said.It took three decades of research to develop the new vaccine, which works against the most common and deadly of the five parasite species that cause malaria. The parasite’s complex life cycle is a huge challenge. It changes forms in different stages of infection and is far harder to target than germs.“We don’t have any vaccines against parasites in routine use. This is uncharted territory,” said Ashley Birkett, who directs PATH’s Malaria Vaccine Initiative, a nonprofit that helped drugmaker GlaxoSmithKline develop the shot, brand-named Mosquirix. The bite of an infected mosquito sends immature parasites called sporozoites into the bloodstream. If they reach the liver, they’ll mature and multiply before spewing back into the blood to cause malaria’s debilitating symptoms. At that point, treatment requires medicines that kill the parasites.Mosquirix uses a piece of the parasite — a protein found only on sporozoites’ surface — in hopes of blocking the liver stage of infection. When a vaccinated child is bitten, the immune system should recognize the parasite and start making antibodies against it.Scientists also are searching for next-generation alternatives. In the pipeline is an experimental vaccine made of whole malaria parasites dissected from mosquitoes’ salivary glands but weakened so they won’t make people sick. Sanaria Inc. has been testing its vaccine in adults, and is planning a large, late-stage study in Equatorial Guinea’s Bioko Island.And the U.S. National Institutes of Health soon will start initial tests of whether injecting people periodically with lab-made antibodies, rather than depending on the immune system to make them, could offer temporary protection during malaria season. Think of them as “potentially short-term vaccines,” NIH’s Dr. Robert Seder told a recent meeting of the American Society of Tropical Medicine and Hygiene.For now, only babies in parts of Malawi, Kenya and Ghana are eligible for the Mosquirix vaccine. After the vaccine was approved in 2015, the World Health Organization said it first wanted a pilot roll-out to see how well it worked in a few countries — in real-world conditions — before recommending that the vaccine be given more widely across Africa. “Everyone is looking forward to getting it,” said Temwa Mzengeza, who oversees Malawi’s vaccine programs. Those eager for the shots include her husband, whom she had to stop from trying to get them, she said.Mzengeza used to come down with malaria several times a year until she started following her own advice to sleep under a net every night. Unlike many other kinds of infections, people can get malaria repeatedly, building up only a partial immunity.In the pilot program that began last year, 360,000 children in the three countries are meant to be vaccinated annually. The first dose is given at about age 5 months and the final, fourth booster near the child’s second birthday.Experts say it is too early to know how well the vaccine is working. They’re watching for malaria deaths, severe infections and cases of meningitis, something reported during studies but not definitively linked to the vaccine.“To do something completely new for malaria is exciting,” said researcher Don Mathanga, who is leading the evaluation in Malawi. The rainy season has brought new challenges, making some rural roads impassable and complicating efforts to track down children due for a shot. So far in Malawi, the first dose reached about half of the children targeted, about 35,000. That dropped to 26,000 for the second dose and 20,000 for the third. That’s not surprising for a new vaccine, Mzengeza said. “It will pick up with time.”At the health clinic in Migowi in Malawi’s southern highlands, workers see signs of hope. Henry Kadzuwa explains the vaccine to mothers waiting at the clinic. He said there was a drop in malaria cases to 40 in the first five months of the program, compared to 78 in the same period in 2018.Even though he wishes his 3-year-old daughter, Angel, could receive the vaccine, “it’s protecting my community. It also makes my work easier,” Kadzuwa said. The Migowi area has one of the country’s highest rates of malaria, and a worn paper register in the clinic’s laboratory lists scores of cases.At the clinic, Agnes Ngubale said she had malaria several years ago and wants to protect her 6-month-old daughter, Lydia, from the disease.“I want her to be healthy and free,” she said. “I want her to be a doctor.”And she has memorized the time for Lydia’s second dose: “Next month, same date.”___Neergaard reported from Washington.___The Associated Press Health and Science Department receives 7200

A Sandusky, Ohio, man was taken to a hospital Wednesday after crashing a car into a bus shelter when he spotted a spider in his car.The 21-year-old man was driving a 2003 Cadillac CTS when he saw the bug, hit a curb and drove through a bus stop shelter on the side of the road, Sandusky police said. The man reentered the road and stopped shortly thereafter.The man was taken to Firelands Regional Medical Center with minor injuries, authorities said. It's not known if the spider sustained any injuries. Knowing spiders, probably not.The man was cited for failure to control, according to police. 609

According to AAA's annual projection released on Thursday, 55 million Americans are expected to travel this year for Thanksgiving, making it the busiest Thanksgiving for travel since 2005.AAA said it expects a 2.9 percent increase in traffic over the Thanksgiving holiday weekend from last year, which marks about 1.5 million additional travelers. Of the 55 million planning to travel more than 50 miles, 49.3 million will do so by automobile. For those planning on traveling the day before Thanksgiving, major delays are expected, especially in major metropolitan areas. “With record levels of travelers, and persistent population growth in the country’s major metropolitan areas, drivers must prepare for major delays,” said Trevor Reed, transportation analyst at INRIX. “Although travel times will peak on Wednesday afternoon nationally, travelers should expect much heavier than normal congestion throughout the week.”If traveling by plane, AAA recommends to travel the Monday before Thanksgiving to take advantage of lower rates. Part of the reason for an increase in travel is due to strong economic numbers, AAA claims. “Strong economic fundamentals are motivating Americans to venture out this holiday in near-record numbers. Consumer spending remains strong, thanks to increasing wages, disposable income and household wealth, and travel remains one of their top priorities for the holiday season," said Paula Twidale, vice president, AAA Travel. 1467

Amazon has turned Prime Day into a summer shopping holiday — and rival retailers like Target want to claim a piece of that spending next week.Target is running "Deal Days" on Monday and Tuesday, July 15 and 16, the same dates as Amazon's two-day Prime Day event. Target said it will offer 40% off some furniture, 30% off some small appliances and cookware, and other deals on toys, sporting goods and bedding.Prime Day has become Amazon's annual summer show of force in the shopping world. Amazon uses the savings event to spotlight its own products and hook new members on Prime, its 9 annual free-shipping program. This year Amazon says Prime Day will include more than one million deals, such as steep discounts on its own Alexa-enabled devices.Target is looking to compete in part by playing up the fact that customers don't need a membership to score deals. This year's two-day event is an expansion: Target held a one-day sale last year, which it called "one of our biggest days of the year for online sales."Other retailers are trying to cash in next week, too.EBay made a more pointed reference to Amazon in its announcement, needling the company for its periodic website outages last year on Prime Day. EBay said it will launch a "Crash Sale" on July 15 to include "hot deals on top brands" over 50% off, with free shipping — and "if history repeats itself and Amazon crashes that day," eBay will add more deals.Nordstrom also hopes to capitalize on the summer version of Black Friday, albeit a few days after the Prime Day event. The company announced it will launch its two-week "anniversary sale" on July 19, with discounts on brands such as Topshop and Madewell. 1690

A school bus driver was arrested after she overdosed while driving and crashed into a tree, Newark police said.The driver, Lisa Byrd, was transporting a dozen students from 14th Avenue School in Newark when the vehicle crashed into a tree on Wednesday, officials said in a statement.When first responders arrived, police said they revived the 57-year-old woman with Narcan -- a drug that instantly reverses the effects of overdose from heroin and other opioids.The students, ages 5 to 13, were not injured, police said.Byrd, who was taken to a local hospital, is facing 12 charges of endangering the welfare of a child, driving while impaired and possession of drug paraphernalia, police said.It was not immediately clear whether Byrd has an attorney."Endangering the lives of Newark children is something we will not tolerate," said Newark Mayor Ras J. Baraka in a statement. "We are grateful that none of the students were injured and that no other residents were harmed due to this incident."The company employing the driver, F&A Transport, has been "removed from transporting children" until an investigation is completed, Newark Public Schools said in a statement.CNN has reached out to the company for comment.The-CNN-Wire? & ? 2019 Cable News Network, Inc., a Time Warner Company. All rights reserved. 1328

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