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WASHINGTON, Oct. 9 (Xinhua) -- U.S. researchers have found a way to block, in an animal model, the damaging inflammation that contributes to many disease conditions. In their report receiving early online publication Sunday in Nature Biotechnology, researchers describe using small interfering RNA technology to silence the biochemical signals that attract a particular group of inflammatory cells to areas of tissue damage."The white blood cells known as monocytes play a critical role in the early stages of the immune response," says Matthias Nahrendorf, of the Massachusetts General Hospital (MGH) Center for Systems Biology, the paper's senior author. "We now know there are two subsets of monocytes -- an inflammatory subset that defends against pathogens and a reparative subset that supports healing. But if the inflammatory response is excessive, it can block the healing process and exacerbate conditions such as heart disease and cancer."Cells damaged by injury or disease release a cocktail of chemicals called cytokines that attract immune cells to the site of the damage. Inflammatory monocytes are guided to sites of tissue injury by a receptor protein called CCR2, and the MGH-led team devised a strategy targeting that molecule to block the inflammatory process but not the action of the reparative monocytes.Small interfering RNA (siRNA) technology prevents production of specific proteins by binding to associated messenger RNA molecules and preventing their translation. However, the technique requires extreme precision in developing the right siRNA molecule and delivering it to the correct cellular location.To make sure that their siRNA preparation targeted the right monocytes, researchers first confirmed that its use reduced levels of CCR2 in monocytes and increased levels of the fragments produced when siRNA binds to its target. They then showed that monocytes from mice treated with the siRNA preparation were unable to migrate towards CCR2's usual molecular target. Experiments in animal models of several important diseases showed that the siRNA preparation reduced the amount of cardiac muscle damaged by a heart attack, reduced the size and the number of inflammatory cells in atherosclerotic plaques and in lymphomas, and improved the survival of transplanted pancreatic islets."These inflammatory monocytes are involved in almost every major disease," Nahrendorf explains. "Anti-inflammatory drugs currently on the market hit every inflammatory cell in the body, which can produce unwanted side effects. This new siRNA treatment doesn't affect inflammatory cells that don't rely on the CCR2 receptor. That makes a big difference."

WINDHOEK, Nov. 29 (Xinhua) -- An agreement on Economic and Technical Co-operation was signed here on Tuesday between the Chinese and Namibian governments.The agreement was signed after Namibian Cabinet ministers and officials from various ministries held talks with Chinese State Councilor Liu Yandong, who arrived in Namibia on Tuesday for a three-day official visit.Minister of Presidential Affairs Albert Kawana, who is the Acting Director-General (DG) of the National Planning Commission (NPC), and Ambassador of China to Namibia Wei Ruixing signed the agreement.The two also exchanged letters on the provision of office supplies and solar energy equipment to the Namibian government by the Chinese government.During their talks, Liu highly spoke of the steady, healthy development of the relations between the two countries.She said the substantial cooperation have been obtained on agriculture, mining and human resources. Great achievements have been made in exchanges of culture and education.The state councilor also said China would like to work together with all African countries including Namibia to promote the development of people-to-people exchanges.Namibia's Deputy Prime Minister Marco Hausiku proposed future cooperation with China in visual and performing arts.He said the Directorate of Arts in the Ministry of Youth, National Service, Sports and Culture is keen to develop future relationships that will lead to bilateral exchanges in arts education, assistance in the development of small arts businesses, the promotion of arts through the exchange of information on arts and participation in events in the respective countries."This can be achieved through the development of ties between the relevant institutions responsible for these areas, such as the line ministries responsible for arts, arts education colleges, performance theaters, art galleries and organizers of events such as festivals and expos," he noted.He also encouraged exchanges between musicians in the sphere of composition, conducting, and instrumental playing in both folklore and symphonic genres, and therefore invited China in the development of Namibia's National Symphony Orchestra.Hausiku also proposed for scholarships in information and communication technology (ICT), particularly policy development and regulatory framework, and linkages with Chinese ICT institutions for exchange purposes.

SAN FRANCISCO, Nov. 17 (Xinhua) -- Online retail giant Amazon is working on a smartphone scheduled to be released in the fourth quarter of 2012, U.S. media reported Thursday.A note from Citigroup analyst Mark Mahaney obtained by technology news site All Things Digital said that based on the supply chain checks in Asia, Amazon is believed to launch a smartphone in the fourth quarter of 2012.According to the note, Amazon is working with manufacturer Foxconn and the device will run Texas Instruments' OMAP 4 processor. The Kindle Fire, the latest tablet introduced by the e- commerce giant, also uses OMAP processor.The analyst said the smartphone will cost Amazon between 150 and 170 U.S. dollars to build and the company could sell the handset at or near its cost rather than a 30 percent gross margin like many other smartphone manufacturers usually do.The move is expected to further intensify Amazon's rivalry with Apple and Google after the e-commerce giant had made moves on some booming businesses like tablet computer and cloud-computing service.

SAN FRANCISCO, Jan. 26 (Xinhua) -- Global tablet shipments reached nearly 27 million units in the fourth quarter of 2011 with Android jumping to a record share of 39 percent, said a new research released on Thursday.According to the research by consulting firm Strategy Analytics, global tablet shipments reached a record high of 26.8 million units in the last quarter of 2011, surging 250 percent from 10.7 million units in the same period a year earlier.Android captured a record 39 percent share of global tablet shipments, rising from 29 percent in the year-ago quarter.Global Android tablet shipments tripled annually to 10.5 million units in the last three months of 2011 and the platform so far is relatively popular with tablet manufacturers, said the research.However, Apple shipped 15.4 million iPads worldwide and maintained its market leadership with 58 percent share during the fourth quarter last year."Apple shrugged off the much-hyped threat from entry-level Android models this quarter," Peter King, director at Strategy Analytics, said in a statement.The research found Microsoft captured a mere 1.5 percent global tablet share in the quarter, noting that "the upcoming release of Windows 8 this year cannot come quickly enough for Microsoft, so its hardware partners can start competing more effectively in the tablet space."In the full year of 2011, global tablet shipments hit 66.9 million units, increasing by 260 percent from 18.6 million units in 2010, according to the research.Consumers are increasingly buying tablets in preference to netbooks and even entry-level notebooks or desktops, said the research.

ATHENS, Jan. 20 (Xinhua) - A seven- month- old Libyan baby died in an Athens Children's hospital on Friday in the first fatality linked to the H1N1 flu virus of the new year in Greece, local authorities reported.According to local media reports citing Greek doctors who treated the boy, he had been infected with the virus in Libya, where he was diagnosed with common flu and received insufficient therapy, before transferred to Greece.An Ukrainian woman who is being treated in another Greek hospital for pneumonia is the second severe case of the swine flu to be reported in the country this season.Last year deaths caused by the H1N1 virus in Greece climbed exceeded the 100 victims and many more patients were treated for complications caused by the virus which first emerged in 2009 in Asia and developed into a worldwide pandemic.Greek Centre for Disease Control and Prevention (KEELPNO) experts noted that Greece does not face a high risk so far this year, but suggested to people of vulnerable groups that reach up to 1.5 million persons in Greece, to get vaccinated.Last year's high number of fatalities was attributed to the fact that several people who should have been vaccinated, skimped vaccination which is not obligatory.

来源：资阳报