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GENEVA, May 3 (Xinhua) -- Roughly half to three quarters of adults aged between 18 to 65 years have had headache in the last year, a prevalent problem that went under-treated, the Geneva based World Health Organization (WHO) said in a report issued Tuesday.The report, named "Of Headache Disorders and Resources in the World 2011," regarded headache disorders as one of the most prevalent disorders of mankind.WHO estimated over 10 percent of the adult population suffered from migraine, and 1.7 to 4 percent of them were troubled frequently by headache on 15 or more days every month.Among all cases studied, the report said, on average only 10 percent were treated by neurologists, and the rates were even lower in Africa and South-East Asia.Three types of headache disorders were underlined as the most frequently seen, including migraine, tension-type headache and that caused by medication-overuse.The report concluded that given the very high indirect costs of headache, investment in health care related to headache treatment might be overall cost-saving to society.
WASHINGTON, April 6 (Xinhua) -- A study led by researchers at the University of Michigan (U-M) showed in animal studies that new cancer drug compounds they developed shrank tumors, with few side effects.The study, done in two mouse models of human cancer, looked at two compounds designed to activate a protein that kills cancer cells. The protein, p53, is inactivated in a significant number of human cancers. In some cases, it is because another protein, MDM2, binds to p53 and blocks its tumor suppresser function. This allows the tumor to grow unchecked. The new compounds block MDM2 from binding to p53, consequently activating p53."For the first time, we showed that activation of p53 by our highly potent and optimized MDM2 inhibitors can achieve complete tumor regression in a mouse model of human cancer," says lead study author Shaomeng Wang, director of the Cancer Drug Discovery Program at the U-M Comprehensive Cancer Center.Wang presented the study Wednesday at the American Association for Cancer Research 102nd annual meeting.Many traditional cancer drugs also activate p53 but they do so by causing DNA damage in both tumor cells and normal cells, causing side effects. These new MDM2 inhibitors activate p53 while avoiding the DNA damage common with other drugs. In this study, which was done in collaboration with Ascenta Therapeutics and Sanonfi-Aventis, researchers showed that these new drugs shrank tumors without significant side effects.Because p53 is involved in all types of human cancer, the new drug has potential to be used in multiple types of cancer. Further, the researchers also identified certain markers in tumors that predict which ones will be particularly sensitive to the MDM2 inhibitor, which would allow physicians to target the drug only to patients most likely to benefit.

PARIS, May 20 (Xinhua) -- Heavy-load launcher Ariane 5, carrying two communication satellites GSAT-8 and ST-2, lifted off at around 22:38 p.m. Paris time (GMT 2038) on Friday from Europe' s Spaceport in French Guiana.Built by Japan's Mitsubishi Electric Company, ST-2 will offer Ku-and C-band relay services across the Middle East, Central Asia, India and Southeast Asia to the ST-2 Satellite Ventures joint company of Singapore Telecommunications Ltd (SingTel) and Taiwan' s Chunghwa Telecom Company Ltd..With a weight around 5.1 tons at launch, ST-2 was separated first around 27 minutes after the lift-off. It has a designed life of 15 years and will function at 88 degree East.The lighter passenger GSAT-8, built by the Indian Space Research Organization (ISRO), will serve to augment India's Ku- band relay capabilities and offer aircraft navigation assistance over Indian airspace and adjoining areas with its two-channel GAGAN system.GSAT-8 was expected to be ejected off around 31 minutes into the flight and will be orbited at 55 degree East. Weighed about 3. 1 tons, it has a designed life span of at least 12 years.Arianespace started its 2011 busy year for heavy-lift Ariane 5 with the milestone launch of Europe's second Automated Transfer Vehicle (ATV) on February 16.The next launch of Ariane 5 planned to lift off two TV broadcast and telecommunications relay satellites: BSAT-3c/JCSAT- 110R for Japan's Broadcasting Satellite System Corporation (B-SAT) and SKY Perfect JSAT Corporation, and ASTRA 1N for Luxemburg-based SES company.
BEIJING, Feb. 9 (Xinhua) -- China's Ministry of Agriculture on Wednesday urged more measures be taken to minimize the impact of a drought due to the possibility that the winter drought may continue into spring.The country's winter wheat producing regions have suffered severe drought since October last year, and the possibility of spring drought is surfacing, Minister of Agriculture Han Changfu said in a statement posted on the ministry's website.Spring drought following the winter one will be a significant threat to summer grain production, he said.As of Wednesday, the drought had affected about 115.95 million mu (7.73 million hectares) of winter wheat in the country's eight key producing provinces, which account for 42.4 percent of the total winter wheat growing areas in the regions, the statement said.China's main wheat growing regions include the provinces of Shandong, Henan, Hubei, Anhui, Shanxi, Shaanxi, Gansu and Jiangsu.Han urged agricultural authorities to be "fully aware of the extreme significance" of a summer harvest this year and strengthen their efforts to assure a successful harvest.Summer grain and oil production is crucial to easing inflation pressures and stabilizing grain output for the entire year, he said. "To have a summer harvest, the current pressing job is to protect winter wheat from drought," he said.There are currently positive factors for a summer harvest, including an adequacy of water for spring irrigation, according to Han.He ordered local agricultural officials to work to stabilize spring planting areas and ensure that the areas for grain planting will be equal to that of last year.Local agricultural officials were also asked to strengthen supervision over market supplies of agricultural materials to keep prices stable.Also on Wednesday, the State Council, or the nation's cabinet, pledged to boost grain production by raising minimum purchase prices of grain, subsidizing the purchase of anti-drought technologies and adding funding for farm irrigation.
SAN FRANCISCO, March 30 (Xinhua) -- History records showed it was not often that large earthquakes caused immediate large volcano eruptions, a geophysicist told Xinhua on Wednesday while talking about whether the recent massive quake in Japan could trigger volcano eruptions.Inevitably, the shaking and changes in the state of stress in the crust could cause some changes in some of active volcanoes closest to the March 11 quake zone in Japan, said Dr. Jian Lin, senior scientist and geophysicist at the Woods Hole Oceanographic Institution in the United States.However, only if a particular volcano was already in a stage of magmatic inflation, a situation close to eruption, would the shaking make a major difference, he noted.Lin is currently visiting the U.S. Geological Survey's earthquake research center in Menlo Park, California to study the March 11 Japan earthquake.Compared with the cases that earthquake triggered volcano eruptions in the past, Lin said, most of active volcanoes in Japan are located somewhat farther away from the March 11 earthquake rupture zones. "The farther away, the less direct effect," he noted.Therefore, "the most important thing is to closely monitor all the active volcanoes in Japan," he said.There are only two well-documented cases of significant volcano eruptions that were apparently triggered by large earthquakes, he said.On Nov. 29, 1975, the Kilauea Volcano in the Hawaiian Islands had a small and short-lived eruption immediately after a magnitude- 7.2 quake hit the Big Island of Hawaii near the volcano, which was probably the best scientifically documented case so far of a volcano eruption triggered by a large earthquake.Records showed that the Kilauea Volvano was already in a stage of inflation before the quake. Meanwhile, the quake was right next to the volcano, which triggered the following eruption.Another case is 1960 Chile earthquake-volcano pair, in which a magnitude-9.5 earthquake, the largest ever recorded by instruments, could have triggered the Puyehue-Cordon Caulle Volcanic Complex ( PCCVC) into a violent eruption within 38 hours. The CCVC had been inactive for 25 years before the quake.Lin pointed out that like the Kilauea case, the earthquake rupture zone in the Chilean quake was again quite close to the volcanic group. However, little scientific monitoring data had been got for the PCCVC before its eruption as it is in a remote area in Chile.In recent years, scientists have observed that large earthquakes from long distance could trigger swarms of small earthquakes in active hydrothermal systems of volcanic regions, he said, noting that "these small earthquake swarms like these are not the same as volcano eruption."Lin added that the relationship between large volcano eruption and large earthquakes is still a poorly studied subject since scientific record is very short and many of large eruptions in the geological history were poorly documented."Therefore, we still know quite little about this subject," he said.
来源:资阳报