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LOS ANGELES, July 18 (Xinhua) -- At least 70 genetic mutations may be involved in the formation of colon cancer, far more than scientists previously thought, a new study suggests.The study by researchers at University of Texas (UT) Southwestern Medical Center contradicts previous thinking that only a few mutated genes may play a role in the development of colon cancer."The ways we've been treating patients up to now is to just go after one target when we should be going after three to four different pathways simultaneously," said Dr. Jerry W. Shay, vice chairman and professor of cell biology at UT Southwestern.The new study identified 65 candidate genes and at least five passenger genes whose mutations play significant roles in cancer development. Inactivating the function of any of these tumor- suppressing genes led to a key step in cancer development called anchorage-independent growth, meaning cells piled up on top of each other rather than aligning neatly.According to previous studies, there were 151 candidate genes and that mutations in just eight to 15 of them would lead to cancer. There were 700 other genes classified as passenger genes whose mutations were incidental to cancer growth.Current cancer treatments target just one or two known cancer- driver genes. While patients may get transient tumor burden reduction, almost universally tumor growth returns."Those numbers are dead wrong," Dr. Shay said, suggesting a new approach to colon cancer treatments targeting multiple genes and pathways simultaneously.The next step is further research to classify more accurately which genes drive cancer and which are merely passengers, the researchers said.Study findings were published in the July 2011 Cancer Research (Priority Reports).

SAN FRANCISCO, July 19 (Xinhua) -- Apple Inc. on Tuesday reported strong third fiscal quarter results that top analysts' expectations, citing strong iPhone and iPad sales.For its fiscal 2011 third quarter ended on June 25, Apple reported net income of 7.31 billion U.S. dollars or 7.79 dollars per share, compared with 3.25 billion dollars, or 3.51 dollars per share a year ago.Its revenue reached 28.57 billion dollars, compared with 15.7 billion dollars in the same period a year earlier. International sales accounted for 62 percent of the quarter's revenue.The average estimate is a profit of 5.84 dollars a share on revenue of 24.9 billion dollars.The Cupertino, Califronia-based company sold 20.34 million iPhones in the quarter, representing 142 percent unit growth over the year-ago quarter. It sold 9.25 million iPads in the third quarter, a 183 percent unit increase on a year-over-year basis.The only drawback is the sales of iPods, which had a 20 percent unit decline to 7.54 million from the year-ago quarter."We're thrilled to deliver our best quarter ever, with revenue up 82 percent and profits up 125 percent," Steve Jobs, Apple's chief executive officer, said in a statement."Right now, we're very focused and excited about bringing iOS 5 and iCloud to our users this Fall," added Job.It is the first time since 2008 that Apple's third-quarter earnings does not include the release of a new iPhone, which, slated for launch in September, is reportedly to be thinner and lighter with a faster chip and 8-megapixel camera.Apple has enjoyed double-digit year-over-year percentage revenue growth for the past four quarters. It had previously beaten the average earning projection for at least 29 straight quarters, according to data compiled by Bloomberg.For the fourth fiscal quarter of 2011, Apple's chief financial officer Peter Oppenheimer said the company expects revenue of 25 billion dollars and earnings per share of about 5.5 dollars. Apple has been known for its conservative projections of earnings.Apple has been operating without the daily attention of Jobs since the CEO took a medical leave this January. The Wall Street Journal reported Tuesday that some members of Apple's board have discussed CEO succession with executive recruiters and at least one head of a high-profile technology company.But the people familiar with the matter told the newspaper that it was more of an informal exploration of the company's options and don't appear to have been acting on behalf of the full board.Meanwhile, Apple has recently been busy with a number of legal battles over patent rights with HTC, Eastman Kodak and Samsung.Last week, the U.S. International Trade Commission made an initial ruling that HTC infringed two of Apple's phone patents in its smartphones powered by Google's Android operating system.If upheld, the ruling could let Apple force other Android phone makers to pay significant patent fees.On Tuesday, Google's executive chairman Eric Schmidt said at a conference in Tokyo that Apple's smartphone lawsuits are inspired by jealousy and a lack of innovation in iPhone, noting Google would support HTC's fight against Apple and was confident of a win.

WELLINGTON, June 7 (Xinhua) -- Scientists in New Zealand have developed a new drug to fight previously untreatable hypoxic cancer tumors, which form in areas of the body starved of oxygen.The researchers at the Auckland University have entered an agreement for the clinical development of CEN-209, which was developed over 10 years of research, said a statement from the university Tuesday.CEN-209 was designed to enhance the effectiveness of radiotherapy and chemotherapy in solid hypoxic tumors, which were resistant to standard cancer therapies, said the statement. In lung cancer patients for example, about half of tumors had hypoxic regions.The new drug worked by damaging the DNA of hypoxic cancer cells, while leaving normal, healthy tissues alone.CEN-209 was designed and created by researchers at the university's Auckland Cancer Society Research Centre (ACSRC), using computer models of drug transport within tumors to accurately predict the anti-tumor activity of the drugs."Our computer models of drug transport developed in-house allowed the synthetic chemists to test their design theories and considerably shortened the discovery process," said Associate Professor Michael Hay, who led the ACSRC research chemists."CEN-209 improves markedly on previous agents in this class in terms of its ability to penetrate tumors, and this is reflected by its improved activity in the laboratory, when combined with long or short courses of radiotherapy," said researcher Professor Bill Wilson.Under the agreement between the university's Auckland UniServices Ltd. and California-based Centella Therapeutics, Inc., a subsidiary of Varian Medical Systems, Inc., Centella will have exclusive rights to CEN-209, which it will develop and trial with Cancer Research UK.The work on CEN-209 is the culmination of a program initiated with funding from the U.S. National Cancer Institute, and more recently from the Maurice Wilkins Centre for Biodiscovery. Ongoing preclinical research on CEN-209 and a backup compound was funded by grants from the Auckland Medical Research Foundation, Genesis Oncology Trust and Health Research Council of New Zealand, said the statement.

LOS ANGELES, May 30 (Xinhua) -- The American Academy of Pediatrics (AAP) warned on Monday that children should keep away from energy drinks which may be dangerous for minors.The AAP urged young children and teens to avoid energy drinks entirely, saying routine consumption of sports drinks should be limited or eliminated.Energy drinks include such popular brands as Red Bull, AMP and Rockstar, the AAP said in a report.These drinks, the report said, tend to be heavily caffeinated, potentially having several times the level of caffeine found in a cup of coffee.In addition, manufacturers often add sugar and herbal stimulants such as guarana and taurine to the drinks, which are popular among kids, according to the report."There's no place for energy drinks for kids," said report co-author Dr. Marcie Beth Schneider, an adolescent physician in Greenwich, Connecticut. "There's a place for sports drinks, but that place is very specific."The caffeine in energy drinks can lead to high blood pressure, high heart rate and insomnia, she said.The other ingredients can boost the power of the caffeine, she said, adding that the drinks will have a greater effect on children because they're smaller than adults."Kids don't need to have this," she said. "This is not something they should be drinking."Schneider declined to identify any energy drinks that may be better than others for kids who insist on drinking them. If kids use energy drinks because they're tired, she said, they should get more rest instead of chugging caffeine.Half of the nation's 5,448 reported caffeine overdoses in 2007 were in people under age 19, although it's not known how many of the cases were the result of energy drink consumption, according to statistics provided by the AAP.

SINGAPORE, July 10 (Xinhua) -- The upcoming Natural History Museum in Singapore launched a drive on Sunday to raise 12 million Singapore dollars (9.8 million U.S. dollars) by the end of the month to buy three dinosaur fossils from a company in Wyoming, the United States.The three dinosaurs on offer from the company Dinosauria International, thought to be a family, were found between 2007 and last year in the United States, the Straits Times reported on Sunday.Appollo and Prince, the two adult diplodocid sauropods, is about 24 meters long, while the baby Twinky is about 12 meters.The natural history museum is expected to be completed by 2014. The three dinosaur fossils will cost 870 million Singapore dollars, and an additional 370 million Singapore dollars will be spent to set up the exhibition."They wanted the museum to tell the story of the history of life and evolution. Dinosaurs are the history of life," said Professor Peter Ng, director of the Raffles Museum of Biodiversity Research, referring to the approval from the scientific advisory committee for the acquisition.The Raffles Museum of Biodiversity Research of the National University of Singapore went on an intensive fund raising campaign last year to build the dedicated Natural History Museum.The museum said it has found the amount to be challenging. It is therefore appealing for help from the public through the media."The idea was always to have a central gallery and put something there that would make people go 'Whoa!,'" said Ng.