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LOS ANGELES (AP) — Broadway soprano Rebecca Luker has died at 59. She was a three-time Tony-nominated actor who starred in some of the biggest Broadway hits of the past three decades. Sarah Fargo, her agent, says Luker died Wednesday. The actor went public in 2020 saying she had been diagnosed with Lou Gehrig’s disease, known as ALS. Luker was the best actress Tony nominee in 1995 playing Magnolia in “Showboat,” the best actress nominee in 2000 for playing Marian in “The Music Man” opposite Craig Bierko, and a best-featured actress nominee in 2007 as Winifred Banks in “Mary Poppins.”Tributes for Luker flooded in after news broke of her passing away. Actress Kristin Chenoweth tweeted that Luker was “one of the main reasons I wanted to be a soprano.”"Her voice was soprano heaven," Chenoweth said. "I love you, Rebecca. I know you’re no longer in pain and already singing your heart out up there." 913

LOS ANGELES (AP) — A fiery crash involving a big rig has injured three people, two critically, and backed up traffic on a Southern California freeway for miles.Authorities say a truck loaded with concrete and gravel hit a car shortly before 3 p.m. Monday on northbound Interstate 405 in the busy Sepulveda Pass area of Los Angeles. The trailer overturned on top of the car, pinning someone underneath and both vehicles burst into flames.Bystanders stopped and managed to pull the trapped person and two others to safety.However, the three reportedly suffered burns, including the truck driver. Two people were hospitalized in critical condition and the third was in fair condition.Lanes on both sides of the freeway were closed, backing up both northbound and southbound traffic. 787

LOS ANGELES (AP) — U.S. authorities allege that Mexico's former defense secretary helped smuggle thousands of kilograms of cocaine, heroin and other drugs into the United States in exchange for bribes.Court documents unsealed Friday in New York alleged that Gen. Salvador Cienfuegos Zepeda acted on behalf of the H-2 cartel while defense secretary from 2012 to 2018 under former President Enrique Pena Nieto.The post positioned Cienfuegos as a critical figure in efforts by Mexico and its allies to combat drug trafficking.He was being represented by a public defender, who did not respond to an Associated Press request for comment.His personal attorney was en route to Los Angeles, where Cienfuegos was arrested Thursday. 731

LOS ANGELES (CNS) - Los Angeles County public health officials announced Friday the county's first known death of a person stemming from the use of e-cigarettes, or vaping -- the fourth such death nationwide. Dr. Muntu Davis, the county's health officer, said the patient was an ``older adult who had chronic underlying health conditions,'' but vaping is considered the probable cause of death. He declined to give the patient's exact age, but said the person was over 55. Public health officials said there have been a total of 12 Los Angeles County cases of illnesses stemming from e-cigarettes, with the illness dubbed vaping-associated pulmonary injury, or VAPI. One of those 12 cases was the person who died. Authorities declined to say if the other 11 patients were still hospitalized. Health officials declined to specify exactly what type of vaping product the person used. Davis stressed that ``it is not clear at this time if there is a specific product or device'' leading to the illnesses. He said that in all but one of the 12 county cases, the patients had a ``history of using a cannabis or marijuana-type product,'' notably THC, the active chemical in marijuana. Echoing a warning issued Friday morning by the U.S. Centers for Disease Control and Prevention, Barbara Ferrer, director of the county Department of Public Health, urged residents ``to stop vaping now until further information about what is causing lung damage and deaths can be understood.'' ``The Los Angeles County Department of Public Health takes this threat seriously and today we're issuing a warning to all residents about the use of these devices as potentially harmful to proper lung function,'' Ferrer said. The Los Angeles County death is the fourth connected to vaping nationally. Authorities in Indiana on Friday morning announced a vaping-related death, and deaths were previously reported in Illinois and Oregon. CDC officials said an investigation into vaping-related cases nationwide found ``clinical similarities among those affected.'' ``We are committed to finding out what is making people sick,'' CDC director Dr. Robert R. Redfield said in a statement. ``All available information is being carefully analyzed, and these initial findings are helping us narrow the focus of our investigation and get us closer to the answers needed to save lives.'' According to the CDC, possible vaping-related illnesses have been reported in more than 25 states. ``While this investigation is ongoing, people should consider not using e-cigarette products,'' according to a CDC statement. ``People who do use e-cigarette products should monitor themselves for symptoms -- e.g., cough, shortness of breath, chest pain, nausea, vomiting, abdominal pain, fever -- and promptly seek medical attention for any health concerns. Regardless of the ongoing investigation, people who use e-cigarette products should not buy these products off the street and should not modify e-cigarette products or add any substances that are not intended by the manufacturer. E-cigarette products should never be used by youth, young adults, pregnant women, or adults who do not currently use tobacco products.'' Davis said the county has been receiving reports since Aug. 14 of ``people experiencing severe and sudden lung disease after having a history of vaping.'' He said the cases are spread across the county, with two-thirds of them in teens and young adults. ``We're not seeing this in just one age group,'' he said, nothing that the cases ``really cross the gamut'' of ages and health history. 3572

LONDON (AP) — Oxford University says trials of a coronavirus vaccine that it is developing with pharmaceutical company AstraZeneca will resume, days after being paused due to a reported side-effect in a patient in the U.K. The university said in large trials such as this “it is expected that some participants will become unwell and every case must be carefully evaluated to ensure careful assessment of safety.” It said globally 18,000 people have received the vaccine so far. Oxford insisted that it is “committed to the safety of our participants.” Pauses in drug trials are commonplace. The Oxford-AstraZeneca vaccine is seen as one of the strongest contenders among the dozens of coronavirus vaccines being tested. 728