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CLEVELAND — Scientists at the Cleveland Clinic Lerner Research Institute have successfully reversed Alzheimer's disease in mice.According to a news release, the researchers reversed the formation of harmful plaque in the mice's brains by gradually reducing an enzyme called BACE1, improving their mental function.“To our knowledge, this is the first observation of such a dramatic reversal of amyloid deposition in any study of Alzheimer’s disease mouse models,” says Riqiang Yan, one of the scientists on the team. The study raises hopes that drugs aimed at this same enzyme will soon be able to treat Alzheimer's disease in humans. You can read the full study in the Journal of Experimental Medicine here. 735

COLORADO SPRINGS, Colo. – A 2-year-old boy who was found early Sunday morning following a statewide search prompted by an Amber Alert has died, a family member has confirmed.Nain Dominguez, 2, was found at around 7:18 a.m. and was hospitalized with life-threatening injuries, according to an official with the El Paso County Sheriff's Office. He was later pronounced dead despite medical intervention, the sheriff's office said in a statement. Details about where the boy was found, or how he sustained those injuries, were not immediately provided by investigators. Biridiana Dominguez, the boy's sister, said the boy "brought a lot of joy to our family." She went on to thank the community and police for their help in finding her little brother. Boy's disappearance prompts statewide searchThe search for Dominguez began at around 5:41 p.m., when deputies received a report that the boy was last seen with an older sibling near Stratmoor Hill Trailhead Park.It would take nearly four hours for Coloradans across the state to be alerted that the toddler was missing via an Amber Alert that was sent out just before 9:30 p.m.Initially, El Paso County deputies reported the boy was last seen being carried by a suspect into a large, white panel van with now windows in the back in the area near 1215 Fountain Road in Colorado Springs.But just after midnight Sunday, both El Paso County deputies and the National Center for Missing and Exploited Children said they no longer believed the van and suspect information initially provided were related to the toddler’s disappearance. 1656

Cotton Incorporated responded on Tuesday to a viral Facebook controversy surrounding a Hobby Lobby decoration that angered a customer.The customer shared a photo of a cotton decoration on Sept. 14, 2017 on Facebook, and said it is reminiscent of slavery and those who were forced to pick cotton. She called for the retailer to remove the item from shelves."We were surprised at the initial post because cotton has been sold in craft stores and used as a botanical decoration for decades," a Cotton Incorporated spokesman said in a statement. "Based on the responses to the original post, it does not seem that most people conflate a decorative choice with a regrettable chapter in American history."On Monday, Sept. 18, the "Cotton Stems in Glass Vase" item on Hobby Lobby's website was on sale for , marked down from .99. It is described as a natural decor with hints of the great outdoors, including large fluffs of white cotton finish on each stem. Cotton Incorporated argues that the cotton industry has changed since the days before the Civil War. "The U.S. cotton industry today bears little resemblance to that of the last century or the one before. Modern U.S. cotton is a socially and environmentally responsible industry that provides textile fiber, feed for animals and food for the growing world population," the spokesman added. Correction: An earlier version of this story incorrectly stated that Hobby Lobby had responded to a request for comment on the controversy. Hobby Lobby has not yet responded to a request for comment. Scripps regrets the error. 1627

Click here to find out how you can help with the funeral costs for a young boy and his uncle who died in a collision in Ramona on Dec. 24. 146

CLEVELAND - What's more awesome than watching elephants at the Cleveland Metroparks Zoo? How about watching elephants chow down on a 1,300-pound pumpkin to kick off the second weekend at Boo at the Zoo.Boo at the Zoo is an annual fall event, currently in its 29th year. The event gives visitors a chance to watch all of their favorite animals being fed, attend a Monster Mash Dance Party, or take part in Trick or Treating and other family-friendly activities.  479

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