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LOS ANGELES, July 18 (Xinhua) -- U.S. scientists have proven that oncogenes can change normal cells into stem-like cells, paving the way to a safer and more practical approach to treating diseases like multiple sclerosis and cancer with stem cell therapy.In a collaborative study, researchers from the Keck School of Medicine of the University of Southern California (USC), and the Children's Hospital of Orange County (CHOC) in California and Good Samaritan Hospital Medical Center in New York have successfully converted human skin cells into brain cells by suppressing the expression of p53, a protein encoded by a widely studied oncogene. This suggests that p53 mutation helps determine cell fate -- good or bad -- rather than only the outcome of cancer.Oncogenes are generally thought to be genes that, when mutated, change healthy cells into cancerous tumor cells.Study findings were appearing Monday on the website of the American Association for the Advancement of Science (AAAS)."The reality may be more complicated than people think," said Jiang F. Zhong, Ph.D., assistant professor of pathology at the Keck School. "What is a stem cell gene? What is a cancer gene? It may be the same thing.""When you turn off p53, people think the cell becomes cancerous because we tend to focus on the bad thing," Zhong said. "Actually, the cell becomes more plastic and could do good things, too. Let's say the cell is like a person who loses his job (the restriction of p53). He could become a criminal or he could find another job and have a positive effect on society. What pushes him one way or the other, we don't know because the environment is very complicated."Stem cells can divide and differentiate into different types of cells in the body. In humans, embryonic stem cells differentiate into three families, or germ layers, of cells. The reasons why and how certain stem cells differentiate into particular layers are not clearly understood. However, from those layers, tissues and organs develop. The endoderm, for example, leads to formation of the stomach, colon and lungs, while the mesoderm forms blood, bone and heart tissue. In its study, Zhong's team examined human skin cells, which are related to brain and neural cells from the ectoderm.When p53 was suppressed, the skin cells developed into cells that looked exactly like human embryonic stem cells. But, unlike other man-made stem cells that are "pluripotent" and can become any other cells in the body, these cells differentiated only into cells from the same germ layer, ectoderm."IPSCs (induced pluripotent stem cells) can turn into anything, so they are hard to control," Zhong said. "Our cells are staying within the ectoderm lineage."Zhong said he expects that suppressing other oncogenes in other families of cells would have the same effect, which could have critical significance for stem cell therapy. Future research should focus on determining which genes to manipulate, Zhong said.The study is slated to appear in the Proceedings of the National Academy of Sciences later this month, according to AAAS.

WASHINGTON, July 20 (Xinhua) -- The loss of a protein that coats sperm may explain a significant proportion of infertility in men worldwide, according to a study by an international team of researchers led by University of California Davis.A paper describing the work was published Wednesday in the journal Science Translational Medicine. The research could open up new ways to screen and treat couples for infertility.The gene DEFB126 encodes a protein called Beta Defensin 126, which coats the surface of sperm and helps it penetrate cervical mucus in the female. A survey of samples from the U.S., Britain and China showed that as many as a quarter of men worldwide carry two copies of the defective gene.In the new study, researchers found that men with a muted DEFB126 lack Beta Defensin 126, making it much more difficult for sperm to swim through the mucus and eventually join with an egg.Examining 500 newly married Chinese couples, researchers found that the lack of Beta Defensin 126 in men with the DEFB126 mutation lowered fertility (even among men that did not display other deficiencies usually associated with infertility, like inadequate semen volume and low sperm motility). Wives of men with the Beta Defensin 126 variant were significantly less likely to become pregnant than were other couples, and 30 percent less likely to have a birth.This genetic variation in DEFB126 likely accounts for many unexplained cases of infertility, researchers say. They hope next to work with a major infertility program in the U.S. to further explore the role of the mutation.

BERLIN, June 8 (Xinhua) -- German health minister Daniel Bahr expressed cautious hope Wednesday for an end to the wave of E. coli infections as authorities reported two more deaths and more than 300 new cases."I can't give an all-clear, but after the analysis of the latest data we have reasons for hope, as the number of new infections is continuously dropping," Bahr told local public television ARD before an emergency meeting in Berlin with European Union Health Commissioner John Dalli."Unfortunately, there will be new cases and more deaths have to be expected, but overall new infections are clearly going down," he said.On the same day, Germany's national disease control center, the Robert Koch Institute, said the number of reported cases in Germany had risen by more than 300 to 2,648. Nearly 700 of those affected have been taken to hospital with a serious complication that can cause kidney failure.The Institute did not fully support Bahr's optimism. It said there was a declining trend in new cases but added it was not clear whether this was because the outbreak was truly waning or because consumers were staying away from the raw vegetables believed to be the source of the E. coli.The German government has faced increasing criticism from abroad and at home over its dealing with the crisis. It was twice wrong in naming the source of the outbreak and it has been criticized for a lack of coordination between research institutes.Dalli was quoted by local daily Die Welt as saying, "we have to rely on the experience and expertise across Europe, and even outside Europe."The Max Planck Institute for Infection Biology in Berlin also called for a federal government representative to coordinate the various government agencies dealing with the disease to eliminate mixed messages.

GENEVA, Aug. 10 (Xinhua) -- In a bid to prevent millions of deaths and suffering every year from malnutrition, the Geneva-based World Health Organization (WHO) launched an online initiative on Wednesday.The e-Library of Evidence for Nutrition Actions (eLENA), according to WHO, offers the latest advice on tackling the three main forms of malnutrition, including undernutrition, vitamin and mineral deficiencies, as well as overweight and obesity.The recommendations by eLENA to tackle malnutrition include promoting breastfeeding and fortifying staple foods with vitamins and minerals such as iron and folic acid for wheat and maize flours.It also recommends using multiple micronutrient powders to fortify foods for children aged between six and 23 months.To prevent anaemia, daily iron and folic supplements are advised for pregnant women, and intermittent iron and folic acid supplementation is recommended for menstruating women and preschool and school-age.While overweight and obesity affect around 1.5 billion adults over age 20, and more than 40 million children aged under five across the world, underweight is the leading risk factor for many diseases in low-income countries and represents about six percent of the world medical burden, WHO statistics showed.

WUHAN, Aug. 6 (Xinhua) -- A Chinese man nearing 80 years old was recently diagnosed with HIV and doctors say he probably caught the virus through having "frequent unprotected sex."The case is the latest to support the opinions of experts who believe the virus is spreading fast among older Chinese men who have been largely neglected in the country's anti-AIDS campaigns.The latest diagnosed man, whose identity has been concealed for privacy reasons, was admitted to Zhongnan Hospital in central Chinese city of Wuhan with a lingering fever. He was later found to be HIV positive, doctors at the hospital said Friday.The man was widowed in his old age, has no record of blood transfusions, but had an "active unprotected sexual life," they said.Gao Shicheng, a HIV specialist in Zhongnan Hospital, said that HIV/AIDS has started to infect middle-aged and elderly Chinese men who have little or no AIDS prevention knowledge.Gao said this year alone he had diagnosed two senior men with HIV. Both contracted the virus through unprotected sex outside marriage.A recent survey conducted by the Chinese Center for Disease Control and Prevention (China CDC) shows that among the new HIV infections, the percentage of people aged 50 or above with it grew from 7.8 to 14.9 percent. Most of them were male and were found to have contracted the virus through sexual intercourse.Experts say the spread of HIV/AIDS has picked up among older Chinese men in recent years because China's senior citizens have become healthier, more open-minded about sex, and increasingly bored after retirement.They called for anti-AIDS campaigns, which usually target young people with a focus on gays, sex workers, and rural migrants, to also cover seniors in a bid to raise the awareness of HIV/AIDS prevention knowledge.China is fighting a hard battle to contain the spread of HIV/AIDS. According to a UNAIDS estimate, the country had about 740,000 people living with HIV by the end of 2009. Among them, 105,000 were estimated to have AIDS.By the end of August 2010, the cumulative total of reported HIV positives in China was 361,599, with 65,104 recorded deaths.Sex, other than blood transmission or mother-to-child transmission, has become the main channel for the spread of HIV in China.