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SAN DIEGO (KGTV) — In some of the most severe cases of COVID-19, doctors are finding it’s not the coronavirus making people critically ill.It’s their own immune system, and a San Diego-based biotech company thinks it has an answer.La Jolla-based INmune Bio announced Tuesday it has FDA approval to begin a Phase 2 clinical trial on its inflammation fighting drug, Quellor.In many of the sickest COVID patients, doctors have noticed their blood is filled with high levels of immune proteins called cytokines. Cytokines act as messengers between cells and the virus can cause them to go haywire, setting off what’s known as a cytokine storm.In a cytokine storm, the body’s immune system starts to attack its own cells and tissues rather than the virus. During the Spanish Flu of 1918, many of the deaths were caused by cytokine storms.“You need to control the cytokine storm to keep patients from getting sick,” said INmune Bio’s CEO Dr. R.J. Tesi.There are several different types of cytokines. A drug undergoing testing in a federal trial with remdesivir targets a cytokine called beta interferon.The San Diego biotech’s drug Quellor suppresses a very specific cytokine called soluble tumor necrosis factor, which Dr. Tesi calls “the master cytokine” because of its role in triggering other immune proteins.Dr. Tesi said this particular cytokine may contribute to another troubling issue with COVID-19: blood clotting.“When they write the history of COVID-19, the clots are going to be the bad guy,” Dr. Tesi said. “These blood clots go off everywhere and they gum up the works. They make it so the lungs can't work. They make it so the kidneys can't work. They make it so the heart is screwed up. Make it so you have strokes.”INmune Bio, which is publicly traded but has just six full-time employees, is hoping its drug can address both the blood clots and the inflammation.The company plans to enroll 366 hospitalized COVID-19 patients for a Phase 2 trial to see if intervention with Quellor can keep people off ventilators and out of the ICU. 2053

SAN DIEGO (KGTV) -- It’s now been a week since the first Americans began their quarantines at MCAS Miramar after evacuating from the epicenter of the coronavirus, and all Charles Wasserburger wants is one thing: a pizza.“I’m just eating the food they have here and suffering through all the pizza and burger commercials they have on TV,” he said.To be clear, the Nebraska native says he’s not complaining about conditions on the base where he has been on a mandatory 14-day quarantine since Feb. 5. The government has provided all 232 evacuees at Miramar with televisions and cell phones to call or video chat with loved ones, free of charge. RELATED: Second case of coronavirus confirmed in San Diego CountyBut after seven days of meals provided by the government -- mostly catered Chinese food -- Wasserburger knows there’s glorious pizza just beyond his reach.“I really did beg to have a pizza delivered because there’s a Pizza Hut like a mile away,” he said. Wasserburger works for a microbiology company. He was in Wuhan, China on business when the outbreak began. He hasn’t shown signs of the virus, but with two cases now confirmed among evacuees at Miramar, his wife in Omaha is a little worried on his behalf.“Even when you’re trying to keep a positive attitude, which he has done, there’s still going to be those days when you’re second guessing, “Could I be that person that comes down with that horrible thing next?” Fauniel Wasserburger said.The evacuees are allowed to mingle with each other in quarantine, although they’re supposed to stay six feet apart. Their only contact with the outside world is through video chat and package deliveries.“We had 180 packages from Amazon delivered yesterday, including fresh foods,” said Caroline Thorman, a spokeswoman for the Department of Health and Human Service Administration For Children and Families.RELATED: Mislabeled sample led to release of San Diego coronavirus patientDeliveries to the base must be screened first, then they can be taken to the lobby of one of the two hotels where evacuees are staying, Thorman said. Anyone who interacts with people under quarantine must wear personal protective gear.Thorman said evacuees have received a number of donations from the community, including books, children’s toys and diapers. The Red Cross provided comfort kits. Anyone wishing to make a donation in the San Diego area should call 2-1-1, she said.“We want to make it easy as possible and as comfortable as possible for these returning Americans,” she said.It wasn’t immediately clear why pizza posed an added challenge, but Thorman said she was happy to accommodate the request. 2654

SAN DIEGO (KGTV) — Local and federal authorities raided four San Diego County homes Wednesday as part of a money laundering investigation.Agents served one of those warrants at an El Cajon home at about 7 a.m., according to neighbors. Agents could be seen removing several items from the property. 10News observed agents searching through the first and second floors of the home. Neighbors told 10News agents made requests over a speaker for the home's residents to exit the property. Neighbors added that eventually, the announcements stopped and they heard what they described as a small explosion, before agents entered the home in tactical gear.RELATED: Ex-Wells Fargo banker indicted for money laundering appears in courtLauren Mack, with the Department of Homeland Security, told 10News the raid was one of five instances in which agents served search warrants as part of an investigation into a suspected money laundering conspiracy. Four locations were in San Diego County and one was in Los Angeles County.Federal agents worked with San Diego Homeland Security Investigations to serve the local warrants.No arrests have been made, according to Mack. 1166

SAN DIEGO (KGTV) — Memorial Day Weekend kicked off Friday night on the USS Midway. As a part of their Legacy Week, they had their annual benefit concert. This year, Daughtry took the stage. Kevin Beam is a big fan and made sure to buy his tickets early, “you got Memorial Day Weekend, Daughtry and beautiful San Diego”. People filled the top deck of the Midway. Ahead of the concert, the USS Midway Foundation presented three ,800 checks to different local charities. The night served as a way for people to remember and honor those who gave the ultimate sacrifice. Penny Erickson was especially grateful for the event Friday, “I’m from a military family my dad was from Pearl Harbor so it means a lot to me.” Chuck Erickson is a volunteer for the USS Midway and a veteran. Friday night, he tells 10News he’s making sure he is grateful all weekend long, “a lot of people lost their lives giving us the freedom we have today”. The USS Midway will have there Legacy Week events through Memorial Day. 1009

SAN DIEGO (KGTV) - Less than two weeks before Halloween, people across the county are getting creative and building candy chutes in hopes of a safer version of door-to-door trick-or-treating.In the yard of the Witthoft home in Lakeside, a large display stands in testament to a four-decade old family tradition of Halloween fright."We love Halloween. It's a fun holiday, a scary holiday. Seeing people dressed up. It's a lot of fun," said Chris Witthoft.Witthoft says part of that fun is handing out candy. That tradition, like so many things this year, is wrapped in uncertainty because of the pandemic."We've done it for so long. Just don't want to let the kids down," said Witthoft.So Witthoft and her family decided to build their own solution: two candy chutes created from PVC pipes and then painted. Witthoft and other family members will push the candy down the chute, staying six feet from the kids."All of us will have gloves and masks on, with social distancing circles along our fence," said Witthoft.Witthoft says the line to get to the candy will be socially distanced, while the chute and nearby areas will be constantly wiped down.To the west, in Rolando Village, Amberosia Vivar has designs on her own candy slide."Will make it out of PVC pipe ... It brings a little excitement for families stuck inside for months. I know my kids have been looking forward to Halloween for months," said Vivar.Across social media, ABC 10news has seen countless examples of San Diegans creating similar candy chutes, but is it safe? County guidelines recommend against any door-to-door trick-or-treating, a chief concern is kids congregating to get the candy. That 'congregating' is also a potential issue with the candy chutes. It's something the Witthofts and Vivar say they'll be watching out for."We can remind the kids, remind the families, maintain your distance," said Vivar."We want to be as safe as possible but still want to carry on our tradition for the kids," said Witthoft. 1995