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WASHINGTON, April 25 (Xinhua) -- A class of drugs that shows promise in breast and ovarian cancers with BRCA gene mutations could potentially benefit colorectal cancer patients with a different genetic mutation, a new study from the University of Michigan Comprehensive Cancer Center finds.Working in cell lines from colorectal cancer patients, researchers found that the class of drugs called PARP inhibitors worked against tumors with mutations in the MRE11 gene.About 15 percent of all colorectal cancers have what's called microsatellite instability, a type of error in the DNA. About 82 percent of those tumors have the MRE11 gene mutation."This is a potential broader application for PARP inhibitors, beyond breast and ovarian cancer. This is a class of drug that's already shown safety in early clinical trials and now might benefit some colorectal cancer patients as well," says lead study author Eduardo Vilar-Sanchez, a hematology/oncology fellow at the university, in a statement.The study, which was published Monday in Cancer Research, also found that PARP inhibitors are even more effective when both copies of MRE11 were mutated. Each person carries two copies of each gene, which means mutations can occur in either one or both copies. The researchers suggest that PARP inhibitors could be targeted specifically to colorectal cancer patients who have two copies of the mutated gene.Researchers are planning a phase I clinical trial to look at using PARP inhibitors in colorectal cancer patients with two mutated copies of MRE11. Future trials are being considered using PARP inhibitors to prevent colorectal cancer and other cancers in people with Lynch syndrome whose tumors have this mutation.Microsatellite instability is also seen in prostate cancer and endometrial cancer, suggesting potential for PARP inhibitors to play a role in additional types of cancer as well, Vilar-Sanchez says, adding that more research is needed in these areas.
BEIJING, March 22 (Xinhuanet) -- NASA scientists are testing its next-generation Mars rover, which will land on Mars next year, under extreme conditions at space-simulation chamber in California, media reports said Tuesday.Scientists at NASA's Jet Propulsion Laboratory in Pasadena, Calif., say they've installed the Curiosity rover in a space-simulation chamber that can mimic the environment the probe will encounter on Mars. After the chamber's large door was sealed last week, air was pumped out to near-vacuum pressure, liquid nitrogen in the walls dropped the temperature to minus 130 degrees Celsius, and a bank of powerful lamps simulated the intensity of sunshine on Mars.After the test period, the rover along with other portions of NASA's Mars Science Laboratory spacecraft including the cruise stage, descent stage and backshell -- part of protective covering -- will be shipped to the Kennedy Space Center for final preparation for the launch window from Nov. 25 to Dec. 18, 2011. Curiosity will study whether a selected area of Mars has offered environmental conditions favorable for microbial life and for preserving evidence about whether Martian life has existed.

BEIJING, March 17 (Xinhuanet) -- A new study has shown that gene therapy can reduce symptoms in patients with Parkinson's, media reports said Thursday.The study, published in the journal Lancet Neurology, is the first to show positive results in a test of gene therapy against a sham operation in 45 U.S. Parkinson's patients.The treated group showed a 23.1 percent improvement on a scale of Parkinson's symptoms six months after treatment, compared to a 12.7 percent improvement for patients who received sham surgery, according to the published research."Gene therapy is no longer just a theory," said Michael Kaplitt, a neurosurgeon at New York-Presbyterian Hospital and Weill Cornell Medical Center, and one of the study authors. "We are getting much closer to a reality where this treatment can be offered to patients."In patients with Parkinson's disease, their brains get overactive after losing the normal supply of a chemical called GABA. The new treatment, gene therapy, works by inserting billions of copies of a gene into patients' brains that helps them produce more GABA.Kaplitt said the results might spur similar treatments for other brain disorders like Alzheimer's, epilepsy and depression.
BEIJING, Jan. 20 (Xinhua) -- Major foreign media have been positive in their coverage so far of Chinese President Hu Jintao's four-day visit to the United States, which began Tuesday.AP said Obama was lavishing the grandest of White House welcomes on Hu as the leaders of the two powers looked for common ground on economic and security issues without alienating their domestic audiences."I absolutely believe China's peaceful rise is good for the world, and it's good for America," Obama said.The Washington Post said Obama stated several times that the United States does not fear a stronger China and that Washington has no interest in blocking Beijing's emergence as a superpower.Chinese President Hu Jintao speaks at a welcoming ceremony held by U.S. President Barack Obama on the South Lawn of the White House in Washington, the United States, Jan. 19, 2011It also said Hu's visit, in addition to serious policy matters, featured a fair amount of glitz. He arrived at the White House to a 21-gun salute and was sent off with a state dinner.The Wall Street Journal said President Obama is looking to assure Americans that they should not fear China's economic rise, using Chinese President Hu's high-profile state visit to announce job-creating business deals worth billions of dollars to U.S. companies.The two sides played down differences and stressed areas of cooperation, ranging from a plan to cooperate on nuclear security to an extension of the loan of two Chinese pandas to Washington's zoo.CNN said at a joint news conference held by the two leaders, Obama praised a "spirit of cooperation that is also friendly competition." President Hu told reporters the countries' relationship is based on "mutual respect and mutual benefit."Obama stressed common interests between the nations while toasting the Chinese leader at the White House, CNN said.VOA said dozens of business deals this week will increase U.S. exports by more than 45 billion U.S. dollars and increase China's investments in the United States by several billion dollars.AFP said that, during Hu's visit, the United States and China had announced a raft of trade deals worth 45 billion dollars. The deals, spanning sectors as diverse as agriculture, gasification, railways and hybrid buses, would support 235,000 U.S. jobs."The scope of Wednesday's deals were seen as evidence of the rapidly deepening business links between the two countries," AFP said.The Los Angeles Times said in its report that two leaders "unapologetically acknowledged major differences on economic issues and human rights" in a White House summit Wednesday, but also pledged cooperation to stabilize relations between the world's two largest economies.Obama said the United States hoped to benefit from China's "rapid and peaceful" growth, the report said.The Times of India said, "China's President Hu Jintao arrived in Washington on Tuesday on a four-day U.S. visit that is being watched in every capital on the planet."O Estado de S. Paulo, a local daily newspaper in Brazil, quoted President Hu's words, saying that China and the United States "stand to gain from a sound China-U.S. relationship, and lose from confrontation," thus they needed to discard the "Cold War mentality."The newspaper also said the two nations both hoped to take the visit as an opportunity to rebuild mutual trust despite some frictions over the past year.
JOHANNESBURG, March 8 (Xinhua) -- In order to combat piracy and to improve maritime safety, South African authorities have begun using a sophisticated navigation satellite system, it was announced on Tuesday.Piracy, especially by Somalis, has been increasing along Africa east coast in recent years. The South African Press Association (SAPA) reported on Tuesday that Karl Otto, head of the South African Maritime Safety Authority (SAMSA) announced the surveillance tool at a conference in Durban.Called Long Range Identification and Tracking (LRIT), the system monitors and tracks vessels in waters south of the equator.Otto said the introduction of the LRIT followed concerns over the safety of seafarers, the safety standards of ships within South African waters.Otto said there were high levels of cargo at risk, such as fuels and oils.He said reasons for installing the system included the number of shipwrecks along the South African coast, and the threat of pollution of the marine environment by ships."It also serves as a mechanism to prevent piracy."Otto said the satellite system has the capacity to identify and track vessels up to 1,000 nautical miles (1,850 km) from the South African coastline as well as South African-flagged vessels anywhere in the world."This is a revolutionary development in the security of our seas," he said.SAMSA was determined to protect South Africa's seafarers, its coastline and the marine environment, Otto said.
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