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SAN DIEGO (CNS) - An international team of scientists, led by biologists at the University of California San Diego, has synthetically engineered mosquitoes that halt the transmission of the dengue virus, the university announced Thursday.Scientists at UC San Diego Associate Professor Omar Akbari's lab worked with Vanderbilt University Medical Center to identify a human antibody for dengue suppression. The broad-spectrum antibody stops the transmission of all four known types of the fever, compared to previous experiments, which have been able to limit single strains.The team then designed the antibody "cargo" to be synthetically expressed in the dengue-spreading Aedes aegypti mosquitoes.RELATED: UC San Diego study finds solutions for loneliness"Once the female mosquito takes in blood, the antibody is activated and expressed -- that's the trigger," Akbari said. "The antibody is able to hinder the replication of the virus and prevent its dissemination throughout the mosquito, which then prevents its transmission to humans. It's a powerful approach."Akbari works in the Division of Biological Sciences and is a member of the Tata Institute for Genetics and Society.These lab-engineers mosquitoes could be paired with a dissemination system, making it capable of spreading the antibody throughout wild disease- transmitting mosquitoes, Akbari said.Dengue fever is a virus that poses a severe risk to children and older adults in tropical regions in Asia and Latin America. There are an estimated 390 million infections every year, around 500,000 of which lead to Severe Dengue, and 25,000 people die of the disease every year.RELATED: UCSD Health, San Diego Zoo Safari Park team up to save gorilla's eyesightThe Pan American Health Organization recently reported the highest number of dengue cases ever recorded in the Americas. Infecting those with compromised immune systems, dengue victims suffer flu-like symptoms, including severe fevers and rashes. Serious cases can include life-threatening bleeding. No specific treatment exists and thus, prevention and control depend on measures that stop the spread of the virus.This development could go a long way toward limiting the disease's transmission."It is fascinating that we now can transfer genes from the human immune system to confer immunity to mosquitoes," said coauthor of the paper, Dr. James Crowe, Jr., director of the Vanderbilt Vaccine Center at Vanderbilt University Medical Center in Nashville, Tenn. "This work opens up a whole new field of biotechnology possibilities to interrupt mosquito-borne diseases of man."Akbari's lab is now in the early stages of testing methods to simultaneously neutralize mosquitoes against dengue and a suite of other viruses such as Zika, yellow fever and chikungunya. 2789
SAN DIEGO (CNS) - Authorities Friday publicly identified a 20-year-old man who was found dead of an apparent homicide in a car parked on a Southcrest- area roadside.Patrol officers responding to a report of a possible traffic accident in the 4000 block of Boston Avenue around 11:50 a.m. Wednesday found Ismail Abouabid mortally wounded behind the wheel of the parked vehicle, bleeding from the head, according to San Diego police.Abouabid, who had recently relocated to San Diego from Erie, Pennsylvania, was pronounced dead at the scene, Lt. Matt Dobbs said. Police initially reported that the man apparently had been shot to death but later backed off from those statements.RELATED: Police investigating after man found dead in car in Southcrest``It is very early in the investigation, and little is known about the events leading to (his) death,'' Dobbs said. ``The mechanism for the man's injury is not being released at this time.''Witnesses told investigators three male teenagers had been with the victim shortly before his death.``The group of teenagers walked away towards a nearby park just before the victim was discovered with the injury,'' the lieutenant said. 1182

SAN DIEGO (CNS) - A man who fired a pellet gun at Navy SEAL instructors and trainees conducting a nighttime training exercise near Liberty Station was sentenced on Thursday to a year in jail.Scott Douglass Weaver, 48, pleaded guilty last month to making an attempted threat on a witness and brandishing a replica firearm.Because of credit for time already served, Weaver will spend about 80 more days in local custody before being released, authorities said.Dispatchers received a report of a man shooting at Navy officers shortly before 10:45 p.m. on July 23 in the 2500 block of Laning Road and Weaver was arrested. No military personnel were injured, according to the Navy.Police did not say if Weaver had a motive for firing at the SEALs or if he was even aware of who he was shooting at.In light of the shooting, the Naval Special Warfare Command said it would evaluate its training procedures. Prospective SEALs are known to train in Coronado, the Silver Strand and areas in San Diego Bay. 1003
SAN DIEGO (CNS) - A San Diego-based group of environmental activists launched a 100-day campaign today calling on the region's congressional representatives to support the so-called Green New Deal to mitigate the effects and exacerbation of climate change.San Diego 350 hopes to convince Reps. Susan Davis and Scott Peters, D- San Diego, and Duncan Hunter, R-Alpine, to support the resolution by inundating their offices with calls and postcards from constituents between now and the August congressional recess.Reps. Mike Levin, D-Dana Point, and Juan Vargas, D-San Diego, are already co-sponsors of House Resolution 109, which supports the drafting and adoption of a Green New Deal. The proposal would reduce greenhouse gas emissions to a net-zero level, invest in infrastructure and shepherd the country's economic and energy sectors away from fossil fuels and coal by 2030.Rep. Alexandria Ocasio-Cortez, D-New York, first proposed the concept and introduced the resolution in February."Over 80 years ago, (Franklin Delano Roosevelt) and the Democratic Party created a bold plan to address the biggest economic crisis our nation hadever faced,'' said Masada Disenhouse, San Diego 350's executive director. "Thestakes are even higher now.''San Diego 350 organized demonstrations at Peters' and Hunter's offices in February to call on them to support he proposal. The organization has also held sit-ins and delivered petitions to members of the county's delegation asking them to co-sponsor the resolution.To date, Davis, Peters and Hunter have not done so. Last month, Peters proposed a divergent plan to stem the tide of climate change, which he called a climate playbook. Peters' proposal includes more than 50 bills introduced by both Democrats and Republicans since 2017.San Diego 350 representatives said the organization plans to hold a series of town hall discussions through Aug. 20, when Congress will go on its summer recess, to discuss constituent concerns regarding climate change.The town halls will be held in Davis, Peters and Hunter's respective districts."(Eighty) years from now, will our great grandchildren know that we did everything we could to fight climate change?'' Disenhouse said during a demonstration outside Saturday's Roosevelt Dinner, held by the San Diego County Democratic Party. "Let's start by ensuring that our representatives step up and take action to make the Green New Deal a reality!'' 2437
SAN DIEGO (CNS) - A train struck and killed a pedestrian in Old Town Thursday, authorities reported.The rail fatality in the 4000 block of Taylor Street occurred about 11:30 a.m., according to sheriff's officials.Details on the circumstances of the death, including the victim's age and gender, were not immediately available.Due to the fatality, Coaster passenger-train service was delayed until further notice, North County Transit District advised. The agency sent buses to its Sorrento Valley Station to help affected commuters reach their destinations.Additionally, San Diego police closed Taylor Street from Congress Street to Pacific Highway to provide full access for investigators and emergency personnel.San Diego Crisis Hotline: 888-724-7240 760
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