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The Detroit Lions will play Tampa Bay without interim coach Darrell Bevell, making him the NFL’s first head coach to miss a game because of COVID-19 protocols.Detroit’s coaching staff will also be without defensive coordinator Cory Undlin, defensive line coach Bo Davis, defensive backs coach Steve Gregory, and linebackers coach Ty McKenzie in Week 16.Wide receivers coach Robert Prince will be the team’s third head coach this season on Saturday at Ford Field against the Buccaneers.Bevell was 1-2 after Matt Patricia was fired last month. Quarterbacks coach Sean Ryan will call plays in place of Bevell, who also serves as the team’s offensive coordinator, against the Bucs. Evan Rothstein, who helps the team with research and analysis, will lead the defensive staff.Bevell said Wednesday he had not tested positive for COVID-19, but he was one of the coaches affected by contact tracing. The Lions closed their training facility on Tuesday because one player and one coach tested positive for the coronavirus, and resumed on-field preparations on Wednesday to face Tampa Bay. 1088
The first experimental COVID-19 vaccine in the U.S. is on track to begin a huge study next month to prove if it really can fend off the coronavirus, while hard-hit Brazil is testing a different shot from China.Where to do crucial, late-stage testing and how many volunteers are needed to roll up their sleeves are big worries for health officials as the virus spread starts tapering off in parts of the world.Moderna Inc. said Thursday the vaccine it is developing with the National Institutes of Health will be tested in 30,000 people in the U.S. Some will get the real shot and some a dummy shot, as scientists carefully compare which group winds up with the most infections.With far fewer COVID-19 cases in China, Sinovac Biotech turned to Brazil, the epicenter of Latin America’s outbreak, for at least part of its final testing. The government of S?o Paulo announced Thursday that Sinovac will ship enough of its experimental vaccine to test in 9,000 Brazilians starting next month.If it works, “with this vaccine we will be able to immunize millions of Brazilians,” said S?o Paulo′s Gov. Joao Doria.Worldwide, about a dozen COVID-19 potential vaccines are in early stages of testing. The NIH expects to help several additional shots move into those final, large-scale studies this summer, including one made by Oxford University that’s also being tested in a few thousand volunteers in Brazil.There’s no guarantee any of the experimental shots will pan out.But if all goes well, “there will be potential to get answers” on which vaccines work by the end of the year, Dr. John Mascola, who directs NIH’s vaccine research center, told a meeting of the National Academy of Medicine on Wednesday.Vaccines train the body to recognize a virus and fight back, and specialists say it’s vital to test shots made in different ways — to increase the odds that at least one kind will work.Sinovac’s vaccine is made by growing the coronavirus in a lab and then killing it. So-called “whole inactivated” vaccines are tried-and-true, used for decades to make shots against polio, flu and other diseases — giving the body a sneak peek at the germ itself — but growing the virus is difficult and requires lab precautions.The vaccine made by the NIH and Moderna contains no actual virus. Those shots contain the genetic code for the aptly named “spike” protein that coats the surface of the coronavirus. The body’s cells use that code to make some harmless spike protein that the immune system reacts to, ready if it later encounters the real thing. The so-called mRNA vaccine is easier to make, but it’s a new and unproven technology.Neither company has yet published results of how their shots fared in smaller, earlier-stage studies, designed to check for serious side effects and how well people’s immune systems respond to different doses.Even before proof that any potential vaccine will work, companies and governments are beginning to stockpile millions of doses so they can be ready to start vaccinating as soon as answers arrive.In the U.S., a program called “Operation Warp Speed” aims to have 300 million doses on hand by January. Under Brazil’s agreement with Sinovac, the Instituto Butantan will learn to produce the Chinese shot.___AP journalist Marcelo Silva de Sousa contributed to this report.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 3499

The Department of Justice on Monday filed complaints against 11 individuals believed to be members of the?Central American migrant caravan, accusing them of illegally entering the United States.After a month-long journey by bus, train and on foot, about 100 migrants arrived at the San Ysidro port of entry on the US-Mexico border on Sunday evening, preparing to claim asylum. About 20 to 30 migrants spent the night inside an immigration processing center in Tijuana, Mexico.An organizer of the caravan vowed they would remain at the immigration processing center until "every last one" is admitted into the United States.Two Salvadorans, six Hondurans, and three Guatemalans face charges, a federal law enforcement official told CNN.Ten of them face a misdemeanor charge for allegedly entering the US illegally. Another individual is alleged to have entered the country after they were previously deported, and faces a felony charge.The probable cause statement alleges many of those charged were seen in an area known as Goat Canyon, about 4 miles to the west of the San Ysidro port of entry, on the US side of the border, the official said. Others were seen on the US side of the border about 2 miles west of San Ysidro in an area known as "W-8." 1263
The combined jackpot between Powerball and Mega Millions this week is now more than billion.Tuesday's Mega Millions jackpot, which is now at 7 million, is the largest this lottery has ever seen.The drawing for the record-breaking Mega Millions is at 11 p.m. Eastern today.Wednesday's Powerball drawing is now at 5 million.LIST:?Luckiest lottery numbers: Powerball, Mega Millions most common picksTake a look at the list below for the largest jackpots in U.S. history, according to the Arizona Lottery: 533
The FBI, Homeland Security’s Cybersecurity and Infrastructure Security Agency and the Director of National Intelligence issued a joint statement Wednesday night confirming an investigation is underway over a hack of government networks.Cybersecurity officials at Homeland Security ordered federal civilian agencies to immediately disconnect or power down affected SolarWinds Orion products from their network.Previously, officials said that the network was “compromised.”“The compromise of SolarWinds’ Orion Network Management Products poses unacceptable risks to the security of federal networks,” CISA Acting Director Brandon Wales said earlier this week. “Tonight’s directive is intended to mitigate potential compromises within federal civilian networks, and we urge all our partners—in the public and private sectors—to assess their exposure to this compromise and to secure their networks against any exploitation.”On Wednesday, SolarWinds acknowledged the cyberattack.“SolarWinds has been made aware of a cyberattack to our systems that inserted a vulnerability within our SolarWinds? Orion? Platform software builds for versions 2019.4 HF 5, 2020.2 with no hotfix installed, and 2020.2 HF 1, which, if present and activated, could potentially allow an attacker to compromise the server on which the Orion products run,” the company said. “We have been advised that this incident was likely the result of a highly sophisticated, targeted, and manual supply chain attack by an outside nation state, but we have not independently verified the identity of the attacker.”Federal officials said that the FBI is engaging with victims and is conducting an investigation. 1678
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