天津治疗白癜风症状中医(天津那里看白癜风) (今日更新中)

SAN DIEGO (KGTV) - Sunday, doctors revealed President Donald Trump is taking a steroid, called Dexamethasone, as the latest medication for his coronavirus treatment."We just don't know what's going to happen next, things are very unpredictable," Dr. Christian Ramers, Chief of Population Health at Family Health Centers, said.Ramers has seen thousands of COVID-19 patients and says the disease has two phases, virus production and inflammatory. He said the shift generally happens seven to ten days in."Once things kind of shift, the damage actually comes more from the immune system's response than the virus itself," Ramers said, which is why a steroid like Dexamethasone is prescribed."Where it showed a decrease in mortality was in people who already required oxygen or if they were even sicker than that and were on ventilation," said Ramers, citing a study.Sunday, doctors stated the president received oxygen Friday before being taken to Walter Reed Medical Center, but said his oxygen levels only dipped to 94% and 93%. Normal levels are 95% and above.Ramers said studies show if you give the steroid too early or to someone who has a mild case, it could cause harm. "If you dial down the immune system too early or in a case that is really mild, you might have the opposite effect you're looking for," Ramers said.There's also a list of side effects."If you use them for a chronic basis or for more than a couple of days there is a long list of things it can cause. They can make your bones thinner, it can give you high blood sugar, diabetes, it can make people have trouble sleeping," Ramers said.With the president, as in any case, Ramers said we need to keep watching, "watching very carefully to what's happening day by day, it's going to be very important especially in this 7-10 day period because things could take a turn at any moment."Ramers said there are experimental coronavirus drug trials coming to San Diego, click here for more information or to sign up. 1988

SAN DIEGO (KGTV) — The Food and Drug Administration has released new guidelines to vaccine makers with added safety measures that experts say will push back the timeline, making the release of a COVID-19 vaccine before the election highly unlikely.The guidelines lay out what it will take for companies to secure a fast-tracked authorization for a vaccine, known as an emergency use authorization or EUA.The new guidelines require vaccine makers to follow the volunteers in their clinical trials for a median of two months after their final dose.It’s an important step to see if anyone has a bad reaction, says Dr. Christian Ramers of Family Health Centers of San Diego.“Some of the safety issues that people like me are concerned about might take months actually to develop,” Dr. Ramers said. “My analysis of this is that it's the FDA standing up and saying, ‘We're going to adhere to our rigorous scientific process.’”The White House had resisted the new guidelines from the FDA for more than two weeks. After their release, President Trump described them as a “political hit job.”“New FDA Rules make it more difficult for them to speed up vaccines for approval before Election Day. Just another political hit job!” the president wrote on Twitter Tuesday night.It’s hard to gauge exactly how the two-month buffer affect the vaccine timeline because clinical trials do not start all at once; volunteers are enrolled on a rolling basis. But Dr. Sydney Wolfe of the consumer group Public Citizen said the drug makers have offered clues.“The companies one-by-one are saying, ‘We can’t get anything in until the end of November or the end of December or the beginning of January,’ and that’s a relief,” he said.In a clinical trial, half of the volunteers get the vaccine and half get a fake drug called a placebo.The updated guidelines require companies to have an estimated effectiveness of at least 50 percent, meaning there are 50 percent fewer cases of infection in the group receiving the vaccine compared to the placebo group.The guidelines also instruct companies to have a plan to continue collecting data in their clinical trial even after they get an EUA and the vaccine hits the market.“The worst thing that could happen here is something meets that minimum bar of 50% efficacy, meaning it works pretty well, but then the bottom just falls out from these clinical trials and we don't get the information we need,” he said.Dr. Ramers was initially skeptical of fast-tracking a vaccine with an EUA rather than waiting for full approval since it’s only been done once before, but he’s supportive of the process under the updated guidelines.“I think that's the best way to balance speed and safety,” he said.Still, experts like Dr. Wolfe think going with an EUA over a full approval could backfire. He points out the new guidelines allow up to half of the people in the clinical trial to be tracked for less than two months after their final dose.“All things aren’t equal [between an EUA and full approval] because you don’t have all the information and B, people know that,” he said.Dr. Wolfe is concerned the public will be reluctant to roll up their sleeves and embrace the vaccine if it just has an emergency authorization. Now that the FDA has made the EUA guidelines more rigorous, he thinks waiting for full approval might take just a few more months.The FDA’s new guidance notes that an Oct. 22 meeting of its Vaccines and Related Biological Products Advisory Committee will not be to discuss specific vaccine candidates.Trump previously said he would consider overruling the FDA on its vaccine guidelines in hopes of speeding up the process. There is both health and economic pressure for a vaccine to be developed as the coronavirus continues to claim an average of 800 US lives a day, according to Johns Hopkins University data.However, Dr. Wolfe said the possibility of the president overruling the FDA is unlikely to have an impact now because the vaccine developers themselves have indicated they will follow the FDA guidelines.Additional reporting by Justin Boggs 4090

SAN DIEGO (KGTV) — The back-to-back announcements of promising clinical trial results from Pfizer and Moderna may usher in a new era for vaccine technology.Both companies have candidates that rely on a new kind of vaccine strategy: RNA. Preliminary data show both candidates are more than 90 percent effective.On the surface, the vaccine candidates look like any other you’ve taken. They work by training your body to build up defensive weapons against a virus, like antibodies and T-cells.But instead of training your body by introducing a killed virus or a fragment of a virus, the vaccines from Moderna and Pfizer introduce a set of instructions called messenger RNA enclosed in a little blob of fat.“The key concept of RNA is that they’re messages, and they’re meant as short-term messages,” said Dr. Shane Crotty of the La Jolla Institute for Immunology.Crotty said there are 5,000 to 10,000 messages within a cell at any given time.Once administered, the mRNA in the vaccine instructs some of your cells to make the coronavirus’ signature spike protein. The spike protein on the surface of the coronavirus allows it to infiltrate and hijack cells.Even though the spike protein is just one of about 25 genes the virus has, preliminary results from the clinical trials suggest it is enough material to train the immune system without making the recipient sick.Crotty likened the process of training the immune system to spotting a sedan. If the coronavirus is a car, the spike protein might be the door.“There's no way that car door could turn into a whole car, but it's enough of a piece of a car for your immune system to recognize that car if it saw it again,” he said.Scientists started by sequencing the virus’ DNA from a sick patient, then encoding that genetic sequence into an mRNA instruction molecule that can be read by the manufacturing part of cells.From there, Dr. Crotty said it’s a bit like the messenger app Snapchat.The mRNA gets injected into the body, sending temporary instructions to your cells that last for a while, then disappear. mRNA does not genetically modify cells, he stressed.“They’re around as messages for some period of time and then they go away, and the cells get back to their normal job of reading their own messages instead of reading the messages you’re injecting in the vaccine,” he said.The concept has been around since the 1990s, but there are currently no RNA vaccines on the market for any pathogen, so Dr. Crotty said it’s hard to estimate how long their protective effects will last.Some vaccines offer a lifetime of protection, like the measles vaccine. Others offer decades of protection. The flu vaccine only lasts about six months.Dr. Crotty said the length of protection depends on how fast the virus mutates and how long the immune cells survive in the body.But even if the COVID-19 vaccine turns out to need an annual update, he’s optimistic. The best feature of RNA vaccines is that they can be quickly reprogrammed.Both Moderna and Pfizer are still in their Phase 3 trials, but they expect to finish them by December. Together, they estimate they’ll have enough doses for about 35 million people by the end of this year, primarily for healthcare workers and high-risk individuals. 3250

SAN DIEGO (KGTV) - The City of San Diego and the San Diego Housing Commission announced details about a planned purchase of two hotels to convert into permanent housing for the homeless.After a six-month search, city officials announced the purchase of the Residence Inns in Mission Valley and Kearny Mesa. The price tag: 6.5 million.Scott Marshall of the San Diego Housing Commission says the project draws upon city, county and state funds to turn hotel rooms into 332 affordable apartments for the homeless, many of them currently staying at the convention center as part of the program, Operation Shelter To Home."This is not temporary shelter. They are permanent homes that will provide them a path out of the shelter and off the streets," said Marshall.Marshall says of the 29 sites considered, the two Residence Inns stood out."They were operating as hotels and in good condition. They didn't require a lot of work for people to move in," said Marshall.Federal housing vouchers will help residents with part of the rent. They'll also receive a host of wraparound services."Things like health care, Life skills training and employment assistance to help them get back on their feet and to a more stabile life," said Marshall.The hotels turned apartments reside in commercial areas, with many other motels and hotels as neighbors. SDSU marketing professor Miro Copic says any issues at the sites could turn into pubic relations problems."Tourists and travel agents could see it as a negative, and it may turn away people from the area. The city has to manage this effectively. If it does so, it may not have much of an impact on nearby hotels," said Copic.If the city council approves the purchase in October, the apartments could be ready by December. 1768

SAN DIEGO (KGTV) – The affidavit accusing San Diego County Congressman Duncan Hunter and his wife, Margaret, of prohibited use of campaign contributions, provides shocking details about how the couple allegedly spent the money and covered it up.The grand jury's indictment accused Hunter and his wife of misusing campaign funds on everything from vacations to tequila shots at a restaurant.The affidavit says the Hunters made purchases with campaign funds including more than ,000 for a family trip to Italy, more than ,300 for purchases at Costco, and more than ,000 for airline tickets and hotel rooms for their family and friends.GALLERY: Alleged instances of campaign fund misuse in Hunter affidavitNumerous alleged charges also cover amounts in the hundreds at grocery and retail stores and restaurants, including one charge in 2015 at Disneyland totaling 9.44 for Minnie Mouse Ear headbands and apparel, and another in 2016 for "30 tequila shots and one steak" totaling 2.46 at a restaurant.Charges listed in the affidavit span from San Diego County locales to Washington, D.C."The Hunters illegally converted and stole more than 0,000 in campaign funds to purchase goods and services for their personal use and enjoyment," the affidavit reads. "The Hunters disregarded rules implement by the Treasurer to track legitimate expenses ... and, when pressed by the Treasurer to comply, dismissed the rules as 'silly.'"RELATED: Congressman Duncan Hunter and wife indicted for campaign fund misuseHunter has repeatedly denied any wrongdoing or campaign fund misuse. Tuesday, he categorized the indictment as a "politically motivated" attack."We’re excited about going to trial with this, frankly," Hunter said of the indictment. "This is modern politics and modern media mixed in with law enforcement that has a political agenda. That’s the new Department of Justice."The affidavit says the Hunters overdrew their bank account more than 1,100 times, resulting in bank overdraft fees of about ,761.RELATED: San Diego Congressman Duncan Hunter addresses federal indictment in 10News interviewAs the U.S. Representative for District 50, Hunter has an annual salary of 4,000, according to ballotpedia.org. 2283

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