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A genetic analysis of COVID-19 patients suggests that blood type might influence whether someone develops severe disease.Scientists who compared the genes of thousands of patients in Europe found that those who had Type A blood were more likely to have severe disease while those with Type O were less likely.Wednesday’s report in the New England Journal of Medicine does not prove a blood type connection, but it does confirm a previous report from China of such a link.“Most of us discounted it because it was a very crude study,” Dr. Parameswar Hari, a blood specialist at the Medical College of Wisconsin, said of the report from China. With the new work, “now I believe it,” he said. “It could be very important.”Other scientists urged caution.The evidence of a role for blood type is “tentative ... it isn’t enough of a signal to be sure,” said Dr. Eric Topol, head of the Scripps Research Translational Institute in San Diego.The study, involving scientists in Italy, Spain, Denmark, Germany and other countries, compared about 2,000 patients with severe COVID-19 to several thousand other people who were healthy or who had only mild or no symptoms. Researchers tied variations in six genes to the likelihood of severe disease, including some that could have a role in how vulnerable people are to the virus. They also tied blood groups to possible risk.Most genetic studies like this are much larger, so it would be important to see if other scientists can look at other groups of patients to see if they find the same links, Topol said.Many researchers have been hunting for clues as to why some people infected with the coronavirus get very ill and others, less so. Being older or male seems to increase risk, and scientists have been looking at genes as another possible “host factor” that influences disease severity.There are four main blood types — A, B, AB and O — and “it’s determined by proteins on the surface of your red blood cells,” said Dr. Mary Horowitz, scientific chief at the Center for International Blood and Marrow Transplant Research.People with Type O are better able to recognize certain proteins as foreign, and that may extend to proteins on virus surfaces, Hari explained.During the SARS outbreak, which was caused by a genetic cousin of the coronavirus causing the current pandemic, “it was noted that people with O blood type were less likely to get severe disease,” he said.Blood type also has been tied to susceptibility to some other infectious diseases, including cholera, recurrent urinary tract infections from E. coli, and a bug called H. pylori that can cause ulcers and stomach cancer, said Dr. David Valle, director of the Institute of Genetic Medicine at Johns Hopkins University.Bottom line: “It’s a provocative study. It’s in my view well worth publishing and getting out there,” but it needs verification in more patients, Valle said.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 3086

A group of Las Vegas shooting survivors is coming together to send a very special gift to Jason Aldean. Their goal is to use the gift to ask Aldean to come back to Las Vegas to finish his concert that was tragically interrupted the night of the mass shooting.Tiffany Thomas created a Facebook group called “58 Survivors 1 Last Set." Survivors of the shooting quickly learned about the group and the online community chatted about their stories of that infamous night.“After it happened, all I could think about was Jason Aldean,” said Thomas. “I kept thinking like he was up there, he was on that stage, he was singing for us.”Through the Facebook group, Tiffany met another survivor named Gina McKin. The women came up with the idea to make a Shutterfly book to send to Aldean.McKin took charge of the book and asked everyone to send their favorite pictures of the night before the shooting rang out.The book ended up being 91 pages long to represent Route 91.In the book, McKin dedicated different pages to victims and survivors. Some people wrote messages to Aldean.The 0 book took months to finalize.The group of women are sending the book to Aldean along with a few other special items.They are using the gift to ask Jason Aldean to come back to Las Vegas and finish his set. Their idea is to open the concert up to survivors and victims and families of the victims.“It would just be so bonding and so amazing and so emotional and I think so healing.”Scripps station KTNV in Las Vegas was in touch with Jason Aldean’s communications team about the book.KTNV was told they are excited to see the book but cannot officially comment on if Aldean will be back to perform just yet.The women are putting the package in the mail this week. “I hope that when he opens it, he just sees that we love him and that we know what he’s going through,” McKin said. 1889

A cold front dropping down from Canada will be giving hundreds of thousands of people weather whiplash this week, with 30-to-50 degree 24-hour drops forecasted between Monday and Tuesday for sections of the Rocky Mountain west and western plains.Excessive heat warnings are in effect from southern Oregon to southern Arizona on Monday, according to the National Weather Service. As an early season cold blast moves south, those will be replaced Tuesday with winter weather and frost warnings along the Rockies and western plains, and wind advisories in neighboring states. 580

A man "yelling and spewing some information" about Donald Trump opened fire in the lobby of a Miami-area golf resort owned by the President early Friday, authorities said.Authorities received a call of an active shooter at the Trump National Doral Golf Club at 1:30 a.m., said Juan Perez, director of the Miami-Dade Police.When officers arrived at the scene, the suspect was armed with a handgun and had draped an American flag over a counter, he told reporters.The fire alarm was blaring, Perez said, describing it as the suspect's attempt to lure officers into the lobby.Perez did not provide details on what the shooter was saying about the President. 662

A large group of Magnum, P.I. cosplayers were reportedly ejected from Comerica Park during Saturday's Detroit Tigers game.According to the News-Herald, the 45 men were dressed as Tom Selleck's famous character, Thomas Magnum, for a bachelor party. The group also included a cardboard cutout of Selleck as Magnum.Chris Tuccini, the groom's younger brother, said to the News-Herald the group was told they were ejected because one of them was smoking and they were catcalling."I don't know how that made us all guilty," he said.  555