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WASHINGTON, Jan. 19 (Xinhua) -- New research published this week in Nature Medicine indicates that targeted drugs such as gefitinib might more effectively treat non-small cell lung cancer if they could be combined with agents that block certain microRNAs.The study, led by investigators with the Ohio State University Comprehensive Cancer Center, shows that overexpression of two genes called MET and EGFR causes the deregulation of six microRNAs, and that this deregulation leads to gefitinib resistance.The findings support the development of agents that restore the levels of these microRNAs. It offers a new strategy for treating non-small cell lung cancer, which is responsible for about 85 percent of the 221,000 lung-cancer cases and 157,000 deaths that occur annually in the United States. It also suggests that measuring the expression levels of certain microRNAs -- those controlled by the MET gene -- might predict which lung-cancer cases are likely to be resistant to gefitinib.Epidermal growth factor receptor (EGFR) is frequently overexpressed in non-small cell lung cancer, and this leads to uncontrolled cell proliferation. Gefitinib selectively inhibits EGFR activation and triggers cancer cells to self-destruct by apoptosis. However, non-small cell lung cancer cells inevitably develop resistance to the drug. The study reveals how this resistance occurs."Our findings suggest that gefitinib resistance that is caused by MET overexpression is at least partly due to miRNA deregulation, " says principal investigator Carlo Croce.
SAN FRANCISCO, Nov. 22 (Xinhua) -- Microsoft announced on Tuesday that it has acquired video search engine VideoSurf.In a press release, Microsoft said it will integrate VideoSurf' s technology across its entertainment platform to augment the Xbox 360 ecosystem and evolve search and discovery of entertainment content on Xbox LIVE.Details of the deal were not disclosed. Technology news site TechCrunch cited Israeli business newspaper Calcalist as saying that the company was bought for about 70 million U.S. dollars.The San Mateo, California-based company, founded by four Israelis in 2006, offers a technology that "sees" frames inside videos to make discovering content fast, easy and accurate.Since its founding, VideoSurf has raised 28 million dollars from several sources, including Facebook chief operating officer Sheryl Sandberg and her husband, as well as former U.S. vice president Al Gore.Last month, Microsoft announced that it will bring cable television content to its Xbox video game console over the holiday season, expanding the console into an entertainment hub.The software giant said Tuesday that the latest acquisition will make it easier for world-class video partners to take full advantage of advanced search features.

HONG KONG, Oct. 13 (Xinhua) -- Computer and electronic device maker Lenovo, listed in both Hong Kong and New York, has replaced Dell to become the world's second largest personal computer company, Lenovo said Thursday.Lenovo made the remarks in a statement, citing figures released by International Data Corporation (IDC), a global provider of business intelligence for the consumer technology market.Following five quarters as the fastest-growing PC maker among the world's top vendors, the preliminary IDC data reported that Lenovo has achieved record market share of around 13.7 percent and record quarterly shipment volume of some 12.6 million units.Lenovo CEO Yang Yuanqing said his company had surpassed two competitors to capture the No. 2 spot in worldwide PCs in just two quarters and it was the highest rank that Lenovo has achieved in worldwide PC sales.Given current competitive environment, the new achievement positioned Lenovo as a strong challenger to ultimately become the global market leader, Yang said in the statement."We are growing in the enterprise and the consumer space. And our customers know we are fully committed to the PC market for the long term," he said.At the same time, the Chinese multinational would continue investing in innovative products that would help drive the convergence of technologies and services across all four screens -- smart phones, tablets, PCs and smart TV, Yang said."We must deliver a great user experience across all platforms to achieve our goal and become the leading personal technology company in the world."Lenovo is a personal technology company and a global Fortune 500 company with annual sales worth 21 billion U.S. dollars. It serves customers in more than 160 countries and regions.
ABU DHABI, Jan. 16 (Xinhua) -- Visiting Chinese Premier Wen Jiabao said here Monday that China supports the efforts of European countries, including Iceland, to preserve financial stability and maintain economic growth.Wen made the remarks during his meeting with Icelandic President Olafur Ragnar Grimsson on the sidelines of the 5th World Future Energy Summit.The Chinese premier lauded the significant progress in China-Iceland relations, saying that China eyes on maintaining high-level exchanges, cementing consultation at various levels with Iceland, and consolidating mutual political trust.Chinese Premier Wen Jiabao (R) meets with Icelandic President Olafur Ragnar Grimsson in Abu Dhabi, the United Arab Emirates, Jan. 16, 2012.In coping with the global financial crisis, the two countries should seek opportunities to boost market confidence, expand bilateral trade, promote mutual investment and deepen communications in culture, education and tourism, Wen said.China and Iceland share huge potential of cooperation in such fields as energy conservation, carbon emission reductions, geothermal power and glaciers, Wen noted.Agreeing with Wen's views on bilateral relations, Grimsson expressed his appreciation of China's support for Iceland as well as other European nations in tackling the global financial crisis and reaffirmed his confidence in future bilateral cooperation.Iceland will work with China to deepen cooperation in such fields as new energy, environmental protection, ship-building, and polar regions research to promote the sustainable development of the world, Grimsson stressed.Wen arrived here Monday after concluding an official visit to Saudi Arabia. The trip will also take him to Qatar.
来源:资阳报