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JUPITER, Fla. — Groundbreaking research out of the Scripps Research Institute in Jupiter, Florida found a genetic explanation for the pain processing and sensory issues some children living with autism face."To see the biology in the lab turn out that has parallels to what’s going on in these children takes it so far beyond just an academic endeavor," said Dr. Gavin Rumbaugh, a neuroscientist at Scripps. "You go home every day thinking, unbelievably, I may actually be making a difference in someone's life."One of those children who Rumbaugh hopes to help with his research is 10-year-old Beckett, who lives in Texas."We wanted to understand generally in the lab how genes like SYNGAP1 affect the way the brain functions and we thought what better way was then to look and see how this gene may directly affect sensory processing, and then further on ask the question, 'Does the change in sensory processing actually lead directly to learning, memory and behavioral impairment?' " he said.Beckett has a genetic mutation of SYNGAP1, which researchers have now found causes certain issues he faces, particularly, having an extremely high pain threshold while also experiencing heightened sensitivity to another kind of stimuli. Beckett and other children living with this genetic mutation also often have epilepsy."It's all about quality of life. Everybody deserves to live their best life and that's my mission," said Monica Weldon, Beckett's mom.Weldon said the research being done in Jupiter could change her son's life and the lives of hundreds of other children around the world with the same genetic abnormality and symptoms, some of whom whose families she's connected with online."That is the power I believe of a patient group that is motivated to find treatments for their loved ones," Weldon said. "Also, you've got scientists who are listening. They're willing to listen and they're willing to learn."The next step in Rumbaugh's research is to look at treating the symptoms from the genetic mutation. 2043

Kamala Harris is projected to become the first female Vice President of the United States. She will also be the first Black and first South Asian to hold that office. Her husband, Doug Emhoff, will set his own historic precedent.Emhoff will become the first second gentleman of the country when Harris is sworn in. The spouse of the vice president is typically called the “second lady”, and Emhoff is the first male spouse in the country’s history.Harris’ spouse is an entertainment lawyer and partner at the firm DLA Piper, and has been for the last few years. He took a leave of absence after Harris joined Biden’s ticket so he could focus on the campaign trail, he said at the time.Saturday morning, Emhoff tweeted a picture of him hugging Harris saying, “So proud of you.” 784

Kingsley, Iowa is home to 1,400 people. “Everybody knows everybody,” said resident Chet Davis.Davis owns the town’s single grocery store: Chet’s Foods. The store has been operating for decades, and Davis’ family has owned it for more than 40 years.Generations of the community have come through these doors, but now, Davis is worried this neighborhood staple may have an expiration date.“Whether we can make it the rest of the year, I don’t know,” said the father of four and grandfather of eight.Davis said his store’s sales took a big hit when a new neighbor moved in just a few blocks away. “This year, we had a Dollar General open up in Kingsley,” he said. After the discount store opened, Davis said his profits dropped by about 20-percent.“It’s disheartening,” said Davis. “You just do what you can, and that’s all you can do, so you just gotta kind of accept it. But you don’t want to; you want to fight it.”The loss in income is something he can’t afford for long. “It costs us ,000 a month just in electricity,” said Davis, as he pointed at the cold storage inside his store that’s necessary to keep frozen products, meats and produce fresh.But Davis has a bigger worry: the loss his entire town is about to see.“If we lose our store here in town, if you want a head of lettuce, you’ll have to drive 25, 30 miles. They always talk about a food desert, and that’s what we’ll have here if we end up having to close the store like we did the other one,” said Davis, referring to his second grocery store just a few miles away.What used to be a space packed with fresh produce is now empty, collecting dust. Davis and his family were forced to close just over one year after Dollar General opened right next door.“They came in and took about 30 percent of our business right off the top. A little bit of it came back, but not enough to pay the basic bills,” said Davis.Davis’ story is a snapshot of the incredible growth of dollar stores across the United States over the last decade.There are more than 33,185 stores across the country. That’s more than all the Starbucks and McDonald’s in the U.S. combined. 2124

Justice Ruth Bader Ginsburg was known to have a vigorous workout routine that kept her physically fit while sitting on the highest court in the country.Friday morning, following a ceremony at the U.S. Capitol, her trainer of more than 20 years, Bryant Johnson, paid his respects by doing push-ups by Ginsburg’s casket.Journalists over the years have written about her strength-training and workouts with Johnson. Ginsburg began working out with Johnson after her first battle with cancer, in 1999.In 2017 he wrote a book about her exercise routine, "The RBG Workout: How She Stays Strong...And You Can Too!" When not lifting weights or coaching a client, he works as a clerk in the District courthouse in D.C.Their workouts took a brief hiatus from 2004-2007, when Johnson was deployed to Kuwait, according to USA Today. Johnson is an Army Reservist.Over the years, Johnson also started training with other justices, including Elena Kagan, Ginsburg’s Supreme Court colleague. 983

Jamal Khashoggi's death was pre-planned and was not spontaneous or an accident, Turkey's President Recep Tayyip Erdogan said on Tuesday in a highly anticipated speech, which flat-out denied Saudi Arabia's claim that the journalist's killing was not premeditated."Jamal Khashoggi was the victim of a ferocious murder," Erdogan said, underlining that his killing was not accidental, but meticulously planned. "This kind of brutality is against the collective human conscience."Erdogan also revealed that a Saudi team carried out reconnaissance at two separate locations and cameras and that a hard drive were removed from the kingdom's consulate prior to the journalist's arrival on October 2 for his scheduled appointment."We stated that we would not remain silent and that we would take every step necessary for justice to be done," Erdogan said at a parliamentary address to members of his ruling Justice and Development Party (AKP), two days after promising to reveal "the naked truth" of the Khashoggi case.Erdogan called on the King of Saudi Arabia for the 18 Saudi suspects linked to Khashoggi's death be tried in Istanbul.After weeks of denying any knowledge of Khashoggi's whereabouts, the Saudi government said on Friday that the journalist had indeed died in the kingdom's diplomatic compound in Istanbul. The Saudi story has shifted drastically since Khashoggi was last seen entering the consulate on October 2; the official line is now that he was accidentally killed when a discussion with officials turned into a brawl.Erdogan presented a very different version of events on Tuesday, speaking in Ankara as Saudi Arabia's flagship investment conference got underway in Riyadh, the Saudi capital. Dozens of top business leaders from around the world have pulled out of Crown Prince Mohammed bin Salman's showcase event, known as "Davos in the desert," as questions mount over the Saudi government's role in the death of the Washington Post columnist and US resident.Saudi Foreign Minister Adel al-Jubeir said on Sunday that Khashoggi's killing was part of a rogue operation and that his government would punish those responsible for his "murder."But Turkish officials have maintained from the start that Khashoggi's death was "violently planned" ahead of time, carried out by a team of Saudi operatives dispatched to Istanbul, and subsequently covered up.In the intervening weeks, Turkish officials have released a drip-feed of information related to their investigation into Khashoggi's murder, including surveillance footage shared exclusively with CNN that showed what a Turkish source described as a "body double" leaving the Saudi consulate in Istanbul on the day Khashoggi died. The Saudi operative, said by the Turkish source to be one of a 15-man team sent from Saudi Arabia to kill Khashoggi, was wearing the journalist's clothes and was picked up on surveillance footage at locations around Istanbul.Erdogan confirmed the body double in CNN's exclusive.The Turkish Foreign Minister Mevlut Cavusoglu said Tuesday that evidence uncovered during the investigation has yet to be shared with any country, according to Turkey state-run Anadolu News, but that Turkey was "ready to cooperate in a possible probe into Khashoggi case at UN, international courts.""Jamal Khashoggi's killing is a violently planned and a very complicated murder, which was being covered up," Omer Celik, AKP spokesman, said at the party's headquarters in Ankara on Monday. "I hope those responsible for Khashoggi's killing are punished and no one ever thinks of repeating this."Speaking to reporters on Monday, Erdogan's spokesman Ibrahim Kalin said: "The line our President put since the beginning of this case is very clear. The investigation will continue until the end." 3774