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BEIJING, Oct. 10 (Xinhuanet) -- China's small businesses turned to be the first to ring the alarm as the country is walking a fine line between fighting inflation and maintaining growth.Some entrepreneurs have disappeared and others have jumped off buildings almost every week since April in Wenzhou City, an entrepreneurial capital in eastern China's Zhejiang province, Xinhua reported.The sudden disappearance of the business owners has revealed a surprisingly gloomy picture for the small and medium-sized enterprises (SMEs) in China.RUNAWAY BOSSESAccording to a Xinhua investigation, at least 80 cash-strapped businesspeople in Wenzhou have skipped town or declared bankruptcy to invalidate more than 10 billion yuan (1.6 billion U.S. dollars) in debt.Just last month, two local entrepreneurs in Wenzhou killed themselves by jumping off the buildings and another broke his leg in a similar suicide attempt.The tragedies in Wenzhou are extreme cases of private SMEs struggling to survive a liquidity crunch amid the country's macro control policies set to curb inflation and cool down the over-heated property market.In Wenzhou, one-fifth of the 360,000 small and mid-sized businesses have stopped operating due to cash shortages, according to the city's council for small and medium-sized enterprises.Of the 855 companies surveyed by the Wenzhou Economic and Information Commission, more than 76 percent said they are almost out of money and are struggling to continue production.But many cash-strapped firms are unable to borrow money from banks, and some have turned to China's underground lending market to pool money from individuals and firms.The steep rates of the informal loans pushed some businesses to the brink of collapse.

SHIJIAZHUANG, Oct. 16 (Xinhua) -- Chickens began being domesticated in China about 8,000 years ago, far earlier than in the rest of the world,according to a recent study on fossils uncovered in north China's Hebei Province.Archaeologists said they had unearthed 116 fossil specimens from 23 types of animals, including pig, dog, chicken, tortoise, fish, and clam, at the Cishan Site, a Neolithic village relic in the city of Wu'an.Several bone fragments were identified to be from domesticated chickens, said Qiao Dengyun, head of the Handan Municipal Institute of Cultural Relics and Archaeology."The chicken bones found at Cishan are slightly larger than wild jungle fowls, but smaller than that of a modern domesticated chicken," said Qiao.Qiao said the bone fossils date back to 6,000 BC, earlier than the oldest domesticated chicken previously discovered in India that dated back 4,000 years."Most of the bones were from cocks, indicating that ancient residents used the practice of killing cocks for their meat and raising hens for their eggs," said Qiao.The Cishan Site, which dates back 10,000 years, was first discovered in the 1970s. At the site, experts have found remnants of China's oldest cultivated millet as well as walnut shells, a discovery that challenged the popular belief that walnuts had been brought to China from what is now Xinjiang Uygur Autonomous Region and Central Asia.

HONOLULU, the United States, Nov. 12 (Xinhua) -- Chinese Commerce Minister Chen Deming has said that China-ASEAN Free Trade Area, launched at the beginning of last year, accords with the mutual interests of China and ten nations of the Association of Southeast Asian Nations (ASEAN) and brings advantage to both sides.Chen made the remarks during his meetings with Indonesian Trade Minister Gita Wirijawan and Thai Deputy Prime Minister and Commerce Minister Kittirat Na Ranong on Friday on the sidelines of the week-long Asia-Pacific Economic Cooperation (APEC) meetings held in Honolulu, Hawaii.According to information made available to Xinhua Saturday, Chen said in his meeting with Gita that China and Indonesia have witnessed a sound development of bilateral economic and trade relations. The China-ASEAN Free Trade Area has provided a new platform for the bilateral economic and trade cooperation, with more benefits and opportunities for enterprises from both countries.Chinese enterprises, especially those from the southern part of China, are keen to invest in Indonesia, said Chen, adding that China would like to discuss with Indonesia on creating areas similar to industrial parks so as to attract more Chinese enterprises and enterprises from other countries to invest in the Southeast Asian country.Gita said Indonesia will commit to the consensus reached between leaders of both countries to increase the volume of bilateral trade from current 34 billion U.S. dollars to 80 billion U.S. dollars in three or four years.He welcomed Chinese enterprises to invest in Indonesia, adding it will be conducive to the realization of the trade goal.Saying that the economies of Indonesia and China have been complimentary to each other, Gita expressed the will of comprehensive and long-term cooperation between both sides.During his meeting with Kittirat, Chen first expressed sympathy to the flood victims in the country, saying that China would like to offer assistance to the rescue and reconstruction efforts and strengthen cooperation in areas including infrastructure construction with Thailand.He said China and ASEAN nations should promote the substantial cooperation among member nations of the China-ASEAN free trade area, the largest free trade area in the world, improve infrastructure including highways, railroads, ports, telecommunication and electricity, so as to benefit the enterprises and people in the regions.China encourages enterprises to invest in the ASEAN nations and would like to conduct cooperation with enterprises from Thailand and other countries, Chen added.Kittirat, expressing his gratitude to China's help to the flood disaster, said that Thailand attaches great importance to the China-ASEAN Free Trade Area.Noting that Chinese enterprises are well-experienced in the construction of highways, railroads and bridges, he said Thailand welcomes Chinese enterprises to participate the construction and investment projects in these areas.

WASHINGTON, Jan. 19 (Xinhua) -- New research published this week in Nature Medicine indicates that targeted drugs such as gefitinib might more effectively treat non-small cell lung cancer if they could be combined with agents that block certain microRNAs.The study, led by investigators with the Ohio State University Comprehensive Cancer Center, shows that overexpression of two genes called MET and EGFR causes the deregulation of six microRNAs, and that this deregulation leads to gefitinib resistance.The findings support the development of agents that restore the levels of these microRNAs. It offers a new strategy for treating non-small cell lung cancer, which is responsible for about 85 percent of the 221,000 lung-cancer cases and 157,000 deaths that occur annually in the United States. It also suggests that measuring the expression levels of certain microRNAs -- those controlled by the MET gene -- might predict which lung-cancer cases are likely to be resistant to gefitinib.Epidermal growth factor receptor (EGFR) is frequently overexpressed in non-small cell lung cancer, and this leads to uncontrolled cell proliferation. Gefitinib selectively inhibits EGFR activation and triggers cancer cells to self-destruct by apoptosis. However, non-small cell lung cancer cells inevitably develop resistance to the drug. The study reveals how this resistance occurs."Our findings suggest that gefitinib resistance that is caused by MET overexpression is at least partly due to miRNA deregulation, " says principal investigator Carlo Croce.

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