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The Supreme Court ruled in favor of Booking.com Tuesday in a landmark trademark case.In an 8-1 decision, the Supreme Court upheld a lower court ruling that determined that Booking.com is not a generic trademark because the term held meaning with consumers.Justice Stephen Breyer, a liberal judge, was the lone dissenting opinion.Other businesses including Cars.com, Dictionary.com, Newspapers.com and Wine.com said the outcome in the case would affect their ability to trademark their names too. 503

The Sinaloa drug cartel, once run by one of the most wanted men in the world, El Chapo, has made its way to Northeast Ohio. It's a drug-trafficking ring moving large amounts of drugs from Mexico onto the streets."I don't think people understand how significant and embedded it is in Northeast Ohio," said Keith Martin, Assistant Special Agent in Charge of Cleveland's Drug Enforcement Administration. Authorities recently found a stash house in a Maple Heights neighborhood and another on Cleveland's west side. "The unfortunate fact is the drugs on our streets come from somewhere. Coco plants don't grow in Cleveland. Poppy plants don't grow in Parma, they come from somewhere else. They are, increasingly, in almost every case, the drugs are coming from Mexican cartels," said Justin Herdman, U.S. Attorney for the Northern District of Ohio. A three-year long DEA investigation, dubbed "Operation Loaded Deck," focused on taking down the local arm of the notorious Sinaloa cartel. During the investigation, authorities seized large quantities of heroin, cocaine and fentanyl, some of which were concealed in hidden compartments in cars. The drugs were moved across the U.S.-Mexican border and transported in these cars outfitted with secret traps. "Often times they'll go to great lengths, whether they've constructed a trap in a vehicle or a natural void in the vehicle," Major Gene Smith with the Ohio State Highway Patrol said.Just as astonishing, Cartel members were hiding in plain sight the whole time, even taking in a Cavaliers game — courtside."These aren't street-level dealers, they were dealing in massive quantities and, in return, huge amounts of cash," Herdman said. By the end of the investigation, 29 kilos of cocaine, eight kilos of heroin, a kilo of fentanyl and four pounds of marijuana were seized, along with nearly 0,000, guns, vehicles and dozens of cell phones. Operation Loaded Deck ended with 19 people sent to federal prison for their roles in the drug trafficking organization. 2115

The US Food and Drug Administration approved two cancer treatments, Vitrakvi and Xospata, this week after expedited reviews.Vitrakvi, approved Monday, is "a treatment for adult and pediatric patients whose cancers have a specific genetic feature (biomarker)."The FDA said in a statement that it is the second approved cancer treatment that is based on a tumor biomarker instead of the place in the body where the tumor originated.Vitrakvi will be used for the treatment of solid tumors that have an NTRK (neurotrophic receptor tyrosine kinase) gene fusion that do not have a known resistance mutation, that are not metastatic or where surgical removal is likely to lead to severe morbidity, and that have no alternative treatments or have progressed after treatments.NTRK genes are rare but occur in many types of cancer, the FDA said, such as mammary analogue secretory carcinoma and infantile fibrosarcoma.Xospata tablets, approved Wednesday, are for the "treatment of adult patients who have relapsed or refractory acute myeloid leukemia (AML) with a FLT3 mutation," according to the FDA.Alongside the tablets, the agency also approved a diagnostic to detect the mutation."Approximately 25 to 30 percent of patients with AML have a mutation in the FLT3 gene. These mutations are associated with a particularly aggressive form of the disease and a higher risk of relapse," Dr. Richard Pazdur, director of the FDA's Oncology Center of Excellence, said in the statement.AML is a rapidly progressing cancer that affects the numbers of normal blood cells and calls for continuous transfusions, the FDA said.Both treatments were granted Priority Review designation.Priority Review, established in 1992, means the FDA aims to review the drug or treatment within six months, opposed to 10 months for a standard review."A Priority Review designation will direct overall attention and resources to the evaluation of applications for drugs that, if approved, would be significant improvements in the safety or effectiveness of the treatment, diagnosis, or prevention of serious conditions when compared to standard applications," the FDA says.Both treatments also received?orphan drug?designation, a status granted to drugs for rare diseases or conditions. 2261

The Rev. Al Sharpton vowed to press for justice as he delivered the eulogy Thursday for Stephon Clark, an unarmed African-American man shot dead by Sacramento police.The sanctuary at Bayside of South Sacramento Church overflowed with people, so many sat outside as the funeral for the 22-year-old Clark took place."We will never let you forget the name of Stephon Clark until we get justice," Sharpton told mourners.Sharpton spoke into the microphone while being hugged by Clark's brother Stevante, who had just interrupted the service with an emotional plea to never forget his brother.Police fatally shot Stephon Clark in his grandmother's backyard on March 18, leading to days of protests. Police said they thought Clark had a gun, but only his cellphone was found at the scene. 789

The view from the airplane window just got a little bit weirder -- or at least it did over Ireland.Several airborne sightings of at least one "very bright" unidentified flying object were seen last Friday, according to air traffic control audio logs.Chatter between airline pilots and Irish air traffic control focused briefly on the sightings, with at least four aviators confirming that they'd seen the phenomenon.The exchange began when one pilot asked Shannon air traffic control if there was nearby military activity. When the air traffic controller replied in the negative, the pilot said that she had seen something moving "so fast.""It came up on our left hand side (rapidly veered) to the north, we saw a bright light and it just disappeared at a very high speed ... we were just wondering. We didn't think it was a likely collision course .. (just wondering) what it could be," she said.A pilot on Virgin Flight 76 added that his flight crew had seen "two bright lights at 11 o'clock (which) seemed to bank over to the right and then climb away at speed." 1073