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LONDON — U.K. regulators say people who have a “significant history’’ of allergic reactions shouldn’t receive the new Pfizer-BioNTech vaccine while they investigate two adverse reactions that occurred on the first day of the country’s mass vaccination program. Stephen Powis, the national medical director for the U.K.'s National Health Service in England said Wednesday that health authorities were acting on a recommendation from the Medical and Healthcare Products Regulatory Agency. He says the agency has advised, on a precautionary basis, that "people with a significant history of allergic reactions do not receive this vaccination." Powis added that both people are recovering well.Dr. June Raine, head of the U.K.'s Medical and Healthcare Products Regulatory Agency, told Parliament on Wednesday that the reactions were not seen in clinical trials for the drug.“We know from the very extensive clinical trials that this wasn’t a feature,” Raine said, according to the Associated Press. “But If we need to strengthen our advice, now that we have had this experience with the vulnerable populations, the groups who have been selected as a priority, we get that advice to the field immediately.The FDA is currently weighing whether to approve the Pfizer-BioNTech vaccine for emergency use in the United States. 1325

LOS ANGELES, Calif. – During her first show of her 18th season, Ellen DeGeneres addressed the toxic workplace allegations made over the summer and apologized to those affected.“As you may have heard, this summer there were allegations of a toxic work environment at our show and then there was an investigation,” said the talk show host in a clip released Monday morning. “I learned that things happened here that never should have happened. I take that very seriously and I want to say I am so sorry to the people who were affected.”DeGeneres said she knows she’s in a position of privilege and power and realizes that it comes with responsibility.“I take responsibility for what happens at my show,” she said. “This is the ‘Ellen DeGeneres Show,’ I am Ellen DeGeneres, my name is there, my name is there, my name is on underwear.”DeGeneres said the people at the show have had a lot of conversations over the past few weeks about the workplace and what they want for the future.“We have made the necessary changes, and today, we are starting a new chapter,” said DeGeneres without saying what the changes would be.This was the first time DeGeneres addressed her viewers publicly since BuzzFeed and other news outlets reported about the dozens of current and former employees who said executive producers engaged in sexual misconduct and harassment at the show. Other workers detailed accounts of racism, fear and intimidation, BuzzFeed reports.Three executive producers of the show have been fired since the allegations were revealed.At the end of her opening monologue, DeGeneres announced that Stephen “tWitch” Boss won’t be her DJ any longer. Instead, he’ll act as co-executive producer, because DeGeneres says he’s “such an important part of this show.”DeGeneres also addressed reports that she’s not who she appears to be on television. She says she became known as the “be kind” lady, because that’s how she ends her shows. But that put her in a tricky spot, because people are complex.“I am also a lot of other things,” she said. “Sometimes I get sad, I get mad, I get anxious, I get frustrated, I get impatient. And I am working on all of that. I am a work in progress, and I'm especially working on the impatience thing because, and it's not going well, because it's not happening fast enough, I will tell you that.”Watch the monologue below: 2361

LONDON — Britain's health secretary says London and it surrounding areas will be placed under the highest level of coronavirus restrictions beginning Wednesday as infections rise rapidly in the capital. Matt Hancock said Monday that the government must take swift action after seeing “very sharp, exponential rises” in Greater London and nearby areas. Under Tier 3 restrictions, the toughest level, people can’t socialize indoors and bars, pubs and restaurants must close except for takeout.He said in some areas cases are doubling every seven days. Hancock told lawmakers that officials have identified “a new variant of coronavirus which may be associated with the faster spread in the south of England.” He said so far, about 1,000 cases of the variant have been identified in England, and they have alerted the World Health Organization. At this time, experts in the UK say it does not appear that the new variant of coronavirus is more transmissible, or more infectious or dangerous. "Huge efforts are ongoing at characterising the variant and understanding its emergence. It is important to keep a calm and rational perspective on the strain as this is normal virus evolution and we expect new variants to come and go and emerge over time," Professor Alan McNally, an expert at the University of Birmingham, told the BBC.The World Health Organization is among those studying the new virus strain, which has been identified in other countries in recent months. 1474

LOS ANGELES (AP) -- Families of those killed and wounded in a California shooting rampage three years ago are suing manufacturers and sellers of "ghost gun" kits that provide easy-to-assemble firearm parts that make it difficult to track or regulate owners.A pair of wrongful death lawsuits accuse 13 defendants of negligence, public nuisance and violation of business codes.The cases were brought by Brady United, the nonprofit that advocates against gun violence.One of the defendants calls the suits an attempt to to "frustrate the lawful purpose of making your own firearms."The other defendants didn't immediately respond to media requests for comment. 665

LOS ANGELES (AP) — Authorities say a Los Angeles County sheriff's deputy who said he was shot in a station parking lot was lying.Assistant Sheriff Robin Limon said at a news conference late Saturday that Wednesday's "reported sniper assault was fabricated" by Angel Reinosa, a 21-year-old deputy.A department statement on Thursday had said a round hit the top of Reinosa's shoulder, damaging his uniform shirt but failing to penetrate his flesh.But Sheriff's Capt. Kent Wegener says no bullets were recovered from the scene and detectives saw "no visible injuries." He says Reinosa eventually admitted making up the story and using a knife to cut the two holes in his shirt.Reinosa has been relieved of his duties and will face a criminal investigation. Wegener says Reinosa didn't explain a motive. 807