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A Seattle woman rinsed her sinuses with tap water. A year later, she died of a brain-eating amoeba.Her case is reported this week in the International Journal of Infectious Diseases.The 69-year-old, whose name was not given, had a lingering sinus infection. For a month, she tried to get rid of it using a neti pot with tap water instead of using sterile water, as is recommended.Neti pots are used to pour saline into one nostril and out of the other to irrigate the sinuses, usually to fight allergies or infections.According to the doctors who treated the woman, the non-sterile water that she used it thought to have contained Balamuthia mandrillaris, ?an amoeba that over the course of weeks to months can cause a very rare and almost always fatal infection in the brain.Once in her body, the amoeba slowly went about its deadly work.First, she developed a raised, red sore on the bridge of her nose. Doctors thought it was a rash and prescribed an antibiotic ointment, but that provided no relief. Over the course of a year, dermatologists hunted for a diagnosis.Then, the left side of the woman's body started shaking. She'd experienced a seizure that weakened her left arm. A CT scan showed an abnormal lesion in her brain that indicated she might have a tumor, so doctors sent a sample of tissue for testing.Over the next several days, additional scans revealed that whatever was happening in her brain was getting worse. The mass was growing, and new lesions were starting to show up.Finally, a neurosurgeon at Swedish Medical Center, where the woman was being treated, opened her skull to examine her brain and found that it was infected with amoebae.The US Centers for Disease Control and Prevention rushed the anti-amoeba drug miltefosine to Seattle to try to save the woman's life, but she fell into a coma and died.According to the CDC, most cases of Balamuthia mandrillaris aren't diagnosed until immediately before death or after death, so doctors don't have a lot of experience treating the amoeba and know little about how a person becomes infected.The amoeba was discovered in 1986. Since 1993, the CDC says, there have been at least 70 cases in the United States.As in the Seattle woman's case, the infections are "almost uniformly fatal," with a death rate of more than 89%, according to the doctors who treated her and the CDC.The amoeba is similar to Naegleria fowleri, which has been the culprit in several high-profile cases.In 2011, Louisiana health officials warned residents not to use nonsterilized tap water in neti pots after the deaths of two people who were exposed to Naegleria fowleri while flushing their nasal passages. An official urged users to fill the pots only with distilled, sterile or previously boiled water, and to rinse and dry them after each use."Improper nasal irrigation has been reported as a method of infection for the comparably insidious amoeba," the doctors say in the research paper about the Seattle woman. "This precedent led us to suspect the same route of entry for the ... amoeba in our case."The woman's doctors say they weren't able to definitely link the infection to her neti pot, as the water supply to her home was not tested for the amoeba. They hope her case will let other doctors know to consider an amoeba infection if a patient gets a sore or rash on the nose after rinsing their sinuses.Kristen Maki, a spokeswoman for the Washington State Department of Health, said in an email that "Large municipal water supplies ... have robust source water protection programs" and treatment programs, and she noted that "Well protected groundwater supplies are logically expected to be free of any such large amoeba" such as Balamuthia. 3746

A team at the University of Kentucky is researching a possible treatment for COVID-19 and key helpers are three alpacas; Big Boy, Blue Eyes and Emperor.“It’s a powerful technology that we have at UK (University of Kentucky) and it’s something that hopefully we can develop some therapeutics with,” said Wally Whiteheart, a professor in the Department of Molecular & Cellular Biochemistry.Alpacas, along with llamas and camels, make a special kind of antibody called a nanobody. Nanobodies can be useful in cancer research and for other diseases. Researchers, led by Whiteheart and fellow professor Lou Hersh, are working with a nearby ranch to see what impact alpacas could have on COVID-19.“We, in a sense vaccinate them, and this case with viral proteins, and we make nanobodies to those viral proteins,” explained Whiteheart. “We can then go and purify and identify the nanobodies that bind to the virus and then test them to see if they can inhibit viral infection.”Making the nanobodies is just the first step. The team will see which, if any, can block virus infection and those candidates could move on to clinical trials.There’s still a lot of research and testing to go, and also still a lot of hope.“The cool thing which we’re exploring now is the fact that you might be able to use them as a nasal spray and this actually gets them to the place where the virus is affecting lung tissue,” said Whiteheart.This isn’t the first time the trio of alpacas has helped medical research. Big Boy, Blue Eyes and Emperor have contributed to the university’s nanobody research for more than three years. In that time, they have helped researchers generate more than 50 nanobodies to target proteins involved in a variety of human diseases including cancer, diabetes and neurological disorders.This story was originally reported by Alex Valverde on LEX18.com. 1869

A number of similar crude explosive devices have been sent since Monday to former President Barack Obama, Hillary Clinton, other top political figures and CNN's New York offices.Here is a timeline: 205

A sad sad day but remembering my friend John with the great joy he brought to the world. I will always be proud and happy to have known and worked with this incredible Scouser! X love Paul#JohnLennon?? by Linda McCartney pic.twitter.com/oNL0ihzhvl— Paul McCartney (@PaulMcCartney) December 8, 2020 311

A mother charged with killing her two young sons by placing them in an oven and turning it on was expected to appear in court on Monday but was not at the appearance.Investigators say 24 year-old Lamora Williams put her sons, ages two and one, into an oven and turned it on. The toddlers, 1-year-old Jakarter Penn and 2-year-old Keyounte Penn, had burns on their bodies when police found them at the Oakland City West End Apartments in Atlanta.Lamora Williams' family said she struggled most of her life with mental issues and may have been dealing with postpartum at the time of the incident.It’s a tragedy which her sister thinks could have been prevented.“She had issues and the fact that the state failed her, that’s a problem,” said Tabitha Hollingworth.Plus, family say the writing was on the wall. She routinely left her children home alone and had even attempted to cut her wrists.Wearing dark sunglasses to hide her tears, Brenda Williams is saddened, but not surprised that her daughter is now charged with murder.“Mora wasn’t right, she hasn’t been right and what happened three months ago, that the kids father left her, I told him something tragic is going to happen. She’s going to do something to those kids, she’s going to do something to herself,” said Brenda Williams.Williams is charged with two counts of murder and one count of cruelty to children in the first degree. Her next court appearance is scheduled for November 8.  1458