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WASHINGTON, Aug. 2 (Xinhua) -- The weakness of aging is associated with leaky calcium channels inside muscle cells and a drug already in Phase II clinical trials for the treatment of heart failure might plug those leaks, according to a report published Tuesday in the online edition of Cell Metabolism.Earlier studies by the research team led by Andrew Marks of Columbia University showed the same leaks underlie the weakness and fatigue that come with heart failure and Duchenne muscular dystrophy."It's interesting, normal people essentially acquire a form of muscular dystrophy with age," Marks said. "The basis for muscle weakness is the same." Extreme exercise like that done by marathon runners also springs the same sort of leaks, he added, but in that case damaged muscles return to normal after a few days of rest. A microscopic view shows smooth muscle cells derived from human embryonic stem cells showing the nuclei (blue) and proteins of the cytoskeleton (green) in this handout photo released to Reuters by the California Institute for Regenerative Medicine, March 9, 2009The leaks occur in a calcium release channel called ryanodine receptor 1 (RyR1) that is required for muscles to contract. Under conditions of stress, those channels are chemically modified and lose a stabilizing subunit known as calstabin1.Calcium inside of muscle cells is usually kept contained. When it is allowed to leak out into the cell that calcium itself is toxic, turning on an enzyme that chews up muscle cells. Once the leak starts, it's a vicious cycle. The calcium leak raises levels of damaging reactive oxygen species, which oxidize RyR1 and worsen the leak.The researchers made their discovery by studying the skeletal muscles of young and old mice. They also showed that 6-month-old mice carrying a mutation that made their RyR1 channels leaky showed the same muscular defects and weakness characteristic of older mice.When older mice were treated with a drug known as S107, the calcium leak in their muscles slowed and the animals voluntarily showed about a 50 percent increase in the amount of time spent wheel running. Now in clinical trials for patients with heart failure, the drug is known to work by restoring the connection between costabilin and RyR1.Despite considerable effort to understand and reverse age- related muscle wasting, there are no established treatments available. The new work suggests there may be hope in approaching the problem from a different angle."Most research has focused on making more muscle mass," Marks said. "What's different here is that we are focused not on muscle mass but on muscle function. More muscle doesn't help if it is not functional."

SINGAPORE, July 10 (Xinhua) -- The upcoming Natural History Museum in Singapore launched a drive on Sunday to raise 12 million Singapore dollars (9.8 million U.S. dollars) by the end of the month to buy three dinosaur fossils from a company in Wyoming, the United States.The three dinosaurs on offer from the company Dinosauria International, thought to be a family, were found between 2007 and last year in the United States, the Straits Times reported on Sunday.Appollo and Prince, the two adult diplodocid sauropods, is about 24 meters long, while the baby Twinky is about 12 meters.The natural history museum is expected to be completed by 2014. The three dinosaur fossils will cost 870 million Singapore dollars, and an additional 370 million Singapore dollars will be spent to set up the exhibition."They wanted the museum to tell the story of the history of life and evolution. Dinosaurs are the history of life," said Professor Peter Ng, director of the Raffles Museum of Biodiversity Research, referring to the approval from the scientific advisory committee for the acquisition.The Raffles Museum of Biodiversity Research of the National University of Singapore went on an intensive fund raising campaign last year to build the dedicated Natural History Museum.The museum said it has found the amount to be challenging. It is therefore appealing for help from the public through the media."The idea was always to have a central gallery and put something there that would make people go 'Whoa!,'" said Ng.

BEIJING, Aug. 3 (Xinhuanet) -- NASA Tuesday confirmed a 4-foot in diameter sphere debris as a fuel tank that was part of the space shuttle Columbia's electrical power system,according to U.S. news reports.NASA engineers identified the 4-foot piece of spherical debris as one of the18 tanks that held chilled oxygen and hydrogen used by the shuttle's electricity-generating fuel cells.This Aug. 1, 2011 handout photo provided by the Nacogdoches Police Department shows a 4-feet in diameter sphere found in Lake Nacogdoches, Texas on Monday, Aug. 1. Police say low water levels at the lake during the drought have led to recovery of a container-like object that could be from space shuttle Columbia. The shuttle broke apart and burned in February 2003, scattering remnants over East TexasPolice in the city of Nacogdoches, about 160 miles northeast of Houston, said Monday the low water levels of Lake Nacogdoches during the record drought revealed an unexpected object that could be from space shuttle Columbia. The shuttle broke apart and burned as it re-entered the atmosphere on February 1, 2003.The tank will be moved to the Kennedy Space Center, where the rest of the Columbia is stored. Approximately 40 percent of the spacecraft has been recovered.

SAN FRANCISCO, Aug. 22 (Xinhua) -- Hewlett-Packard's tablet TouchPad has become the hottest consumer electronics device on Monday after HP launched a fire sale for the discontinued product line over the weekend."It was like a stampede and they went quick," a Best Buy employee in San Diego told technology news website Betanews, describing the line waiting to buy TouchPad. He said the discontinued tablet was sold out five minutes after the store opened.The device is also getting snatched up at a lighting speed online and increasingly difficult to find.The TouchPad is no longer listed on Bestbuy.com in the United States, which last week was reportedly sitting on 270,000 unsold TouchPads and was hoping HP would buy them back.On Amazon, TouchPad tops the world's largest online retailer's electronics sales list, beating out the electronic reader Kindle and iPod touch.Last Thursday, HP announced that it will completely shut down its webOS operations, specifically the TouchPad tablet and webOS phones.The 16 GB TouchPad currently is only 99.99 U.S. dollars, compared to the original price of 399 dollars. The 32 GB model, which used to be 485.99 dollars, is now priced at 149.99 dollars.

SAN FRANCISCO, Sept. 12 (Xinhua) -- Amazon.com Inc. is talking with book publishers to launch a rental subscription service for digital books, U.S. media reported on Monday.Several publishing executives said they aren't enthusiastic about the idea because it could lower the value of books and it could also strain their relationships with other retailers that sell their books, The Wall Street Journal quotes people familiar with the matter in a report.The Seattle-based company is considering a digital book library featuring old titles, which would be available to Amazon Prime subscribers, who currently pay 79 U.S. dollars a year for access to digital library of movies and TV shows and unlimited two-day shipping, said the report.Amazon would offer book publishers a substantial fee and could limit the amount of books that Amazon Prime customers could read for free every month, the report cited some sources as saying.The online retailing giant makes the popular electronic reader Kindle and is also reported to launch a color touchscreen tablet before October to compete with Apple's iPad and other devices in the increasingly crowded tablet computer market.The proposal is another sign that retailers are looking for more ways to deliver content digitally as customers increasingly read book and watch TV on personal computers, tablets and other electronic devices, said The Wall Street Journal report.