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SAN DIEGO (CNS) - A COVID-19 vaccine trial sponsored by drugmaker Johnson & Johnson is slated to get underway soon in San Diego, and will include an estimated 2,000 participants at UC San Diego Health, it was announced Thursday.Up to 60,000 participants will be recruited from 10 different countries around the world as the San Diego portion of the trial, dubbed ENSEMBLE, gets underway Oct. 7, according to UCSD.The efficacy, safety and immunogenicity of the drug Ad.26-COV2.S will be tested via a randomized, double-blind, placebo-controlled study, in which half of the participants receive a single-dose injection of the vaccine and the other half receive a placebo. All participants -- who must be 18 years of age or older and in reasonably good health -- will be monitored for signs of infection and COVID-19 over the next two years, according to UCSD.Researchers are particularly interested in recruiting participants at increased risk of SARS-CoV-2 infection due to where they live, their age or personal circumstances, such as working in essential jobs like first responders, health care, maintenance, construction, grocery stores or assisted living facilities.The San Diego trial will also emphasize participation from the region's underserved communities, as communities of color have shown higher rates of COVID-19-related hospitalization and/or death.UCSD cited data from the county showing measurably higher infection rates in the South Bay, including in Chula Vista, Imperial Beach and National City.Susan Little, professor of medicine at UC San Diego School of Medicine and principal investigator of the UC San Diego trial, said, "Many communities of color are experiencing higher rates of hospitalization related to COVID-19 than are observed in white, non-Hispanic people. It is important that these communities are represented in COVID-19 vaccine clinical trials so that we understand if the vaccine will work well within these groups."For more information about participating in the trial at UC San Diego, go to www.covidvaccinesd.com or call 619-742-0433. 2087

SAN DIEGO — The economic fallout from the novel coronavirus is leading to increased opportunities to buy a home or refinance one currently owned. Freddie Mac reported Thursday that the average rate for a 30-year fixed mortgage was 3.29 percent, the lowest in its 50-year history.That's down from 4.41 percent one year earlier. With the new, lower rate, a household with a 0,000 mortgage would save about 0 on their monthly payments. "Anytime there's any sort of any big natural disaster, war threat, that type of thing, the Wall Street money seeks safe havens, and that tends to drive rates down," said Scott Harmes, a senior loan officer at C2 Financial Corp. Harmes said the phones have been ringing off the hook since the rates fell, including for people inquiring to refinance. He said refinances should be evaluated on a case-by-case basis, depending on how much a household owes, how much longer the loan will last, and how long they plan to stay in their home. For those in the market to buy, the lower rates come just as San Diego will enter the spring peak homebuying season. Realtor Michelle Silverman said the higher rates could make the market tighter, but that homes still need to be priced appropriately."A seller can't be greedy," said Silverman, of Coldwell Banker. "If you have a greedy seller, the house is going to stay on the market. If the property is priced right, you're going to get multiple offers, maybe even go above list price, and it will move. It will sell."The rate drop comes after the Federal Reserve lowered its key Federal Funds Rate by 0.5 percent earlier this week in an emergency action. CoreLogic reports that the median home price in the county was 5,000 in January, up 7.9 percent from one-year earlier. 1762

SACRAMENTO, Calif. (KGTV) — California’s Senate has approved a measure to increase the scrutiny of hunting licenses used in gun sales, prompted by last year’s fatal shooting at a Poway synagogue. Senate Bill 914, introduced by Democratic Sen. Anthony Portantino, would require gun stores and the state Department of Justice to both check the validity of hunting licenses during a waiting period after gun buyers purchase a weapon and before they pick it up. The bill will now head to the state Assembly.SB 914 comes after a 10News investigation uncovered that the 19-year-old shooting suspect bought the gun used in the attack at a shop in San Diego using an invalid hunting license. 10NEWS INVESTIGATIONS ON POWAY SHOOTING:New bill aims to correct error that allowed Poway suspect to buy gunQuestions about how the synagogue shooting suspect got the gunProcess to get a hunting license in CaliforniaThe suspect, 19 at the time of the shooting, used that invalid hunting license to claim an exemption to a state law that raised the minimum purchase age to 21.California's age limit law, a bill Portantino authored in 2018, kept the minimum purchase age at 18 for military, law enforcement, and those with valid state-issued hunting licenses."The system should have been better, and that's what we're coming to grips with," Portantino said in an interview with 10News reporter Jon Horn. "How do we make it better, so these things have protections so that it doesn't happen again?"The Associated Press contributed to this report. 1535

SAN DIEGO (AP) -- Eric Hosmer hit a historic shot that made San Diego the first team in the majors to launch grand slams in four straight games, and the Padres needed an unearned run in the 10th inning for a wild, 8-7 win over the Texas Rangers.The Padres swept the four-game, home-and-home series, with a slam in each one. Hosmer's go-ahead shot against Kyle Gibson with one out in the fifth inning bounced off the top of the right field wall and into the seats for a 5-2 lead.Earlier this week, Fernando Tatis Jr., Manny Machado and Wil Myers slammed the Rangers.The Padres' 5-2 lead would not last, as reliever Michel Baez gave up a three-run double to Danny Santana in the top of the 7th. Texas grabbed a 6-5 lead one inning later on a Jose Trevino RBI single.San Diego regained the lead in the bottom of the eighth inning, thanks to back-to-back homers from Ty France and Austin Hedges.Emilio Pagan was sent in to close the game in the top of the ninth, but Nick Solak tied the score at 7-7 with a solo shot to right center.The game went to the 10th inning, and after the Rangers were unable to score in the top half of the frame, Jake Cronenworth's single to center slipped past the glove of outfielder Scott Heineman, allowing Myers to score from second base for the victory. 1290

SAN DIEGO - (KGTV) A San Diego biotech company is doing research that could lead to a vaccine against the coronavirus.Todd Nelson is the CEO of SGI-DNA in Sorrento Valley. His company invented the first automated gene printer. "We use that system actually to print genes. Genes are made of little building blocks that you've heard of, and we use that to rapidly, and in an automated fashion, print genes that researchers can use around the world for vaccine development. "RELATED: Miramar coronavirus evacuees start petition for quarantine oversightThe printer is called the BIO XP 3200. Roughly, 200 are in use around the world. "We're basically taking an entire laboratory of researchers that are doing various things, and we put it in a box," said Nelson.Researchers are using the printer to write the genes of the coronavirus."Even a nasty little thing like the coronavirus has its own genes, and there are certain genes that make that amenable to being a vaccine, and we know what those are so we put the information into the system, and we push a button and about 8 hours later that potential gene comes out ," said Nelson. RELATED: Mislabeled sample led to release of San Diego coronavirus patientNelson is confident the technology will lead to a vaccine. "We're partnering with pharmaceutical firms to develop that in a very, very rapid fashion in the next 7 to 10 days to develop a vaccine," said Nelson. The company used the same technology to help develop a vaccine for the Bird Flu in 2013. Dan Gibson is the company's chief technology officer and the inventor of the technology used in the gene printer.RELATED: First case of coronavirus confirmed in San Diego"That's really the power of synthetic DNA technology. You can keep up with the virus and write and build many vaccines to fight it and ultimately find a universal solution that puts an end to the coronavirus outbreak." 1900

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