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SAN DIEGO (KGTV) -- It's survival of the fittest once again for gyms and fitness centers across the county as San Diego braces for stricter pandemic-related restrictions that go into effect Saturday.One gym preparing for the big shift is major chain 24 Hour Fitness. While members can't choose from their dozens of locations to workout, seven county locations will be open and offering outdoor equipment to members."We're committed to staying outdoors, staying safe, and the well-being of our members is the priority," said 24 Hour Fitness district manager John Amato.Amato told ABC 10News that member visits will be reservation based with 90-minute windows, minimized to 57 guests at a time.While many prepared for what's to come, others like gym owner Tom Green of Green Speed Training in Eastlake did the opposite. Instead of expanding his outdoor space for members, he doubled the square footage on the inside, even though guests won't be allowed to workout indoors until the county falls in a less restrictive tier."It's certainly risky, but I've always been kind of a risk taker and I go with my gut instinct, and if I feel good about it, I go for it," Green said.Since the COVID-19 pandemic began, Green said support from the Eastlake community along with members of his gym have helped keep things afloat and allowed him to upgrade indoor space."It's very supportive, and we have a lot of great clients who really support what we're doing,” said Green.Regardless, both gyms said they'll continue to be there for their clients no matter which tier San Diego slips into next."To get that one-hour workout in, and de-stress to stay healthy, that's what our goal is,” said Amato. 1691

SAN DIEGO (KGTV) — Like Saturday, several cities around the county saw temperatures hit record highs as temperatures baked the county over the holiday weekend.Sweltering heat continued across the county on Sunday, prompting residents to flee for the coast only to be met by more high temps.According to the National Weather Service, several cities saw daily record highs for Sept. 6, with Escondido hitting an all-time high of 115 degrees:San Diego: 100° (old record: 97° in 2011)Oceanside: 85° (old record: 83° in 2004)Vista: 107° (old record: 102° in 2004)Chula Vista: 102° (old record: 97° in 2011)Escondido: 115° (old record: 104° in 1955) — an all-time recordRamona: 112° (old record: 102° in 1983)Palomar Mountain: 98° (old record: 94° in 1955)Campo: 110° (old record: 104° in 1955)Borrego: 117° (old record: 115° in 1989)Saturday, Alpine and El Cajon set all-time highs at 113 and 114 degrees, respectively.Monday, a slight heat reprieve with come to parts of the county. Monday's highs are forecasted for the coast at 80-91°, for the inland areas at 93-99°, in the mountains at 91-103°, and for the deserts at 113-119°. 1135

SAN DIEGO (KGTV) — Local Regal Cinemas are offering an affordable day at the movies all summer long.Regal Cinemas' "2019 Summer Movie Express" series offers movie tickets to select kid-friendly films at 10 a.m. on Tuesdays and Wednesdays at participating theaters.In San Diego, participating theaters include Regal Edwards San Marcos, Regal Escondido, Regal Mira Mesa, Regal Edwards Rancho San Diego in El Cajon, and Regal Partway Plaza in El Cajon.RELATED: Summer Movies in the Park return to San DiegoMoving seats, weather effects come to Mira Mesa theaterAnd movie-goers will be able to enjoy a variety of kid-favorite films like "The LEGO Movie 2," "Secret Life of Pets," "Kung Fu Panda 3," "How to Train Your Dragon," and several more.For a full list of movies and participating locations, visit Regal's website here. 833

SAN DIEGO (KGTV) — In the race for a coronavirus vaccine, scientists often say we need more than one winner.That’s in part because different vaccines use different strategies to provoke the immune system, and each strategy has different strengths.Take the inactivated virus vaccine, an approach currently used in the vaccine against the poliovirus. In this approach, scientists take a live virus, kill it with chemicals or heat, and then introduce that viral corpse into a person.There are three groups in the final phase of human trials using inactivated coronavirus, primarily in China, according to a tracker from the Milken Institute.“The immune system can tell the difference between something that's a real threat and something that's not a threat, and so if you get injected with a dead virus your immune system has the tendency to not pay a lot of attention to that,” said Dr. Shane Crotty of the La Jolla Institute for Immunology.The downside of the inactivated virus approach is that it only elicits two out of the three of the parts of the immune system, Dr. Crotty said. It’s capable of producing antibodies and helper T-cells, but not killer T-cells.The modern take on the inactivated virus approach is called a viral vector vaccine.In this strategy, scientists combine elements of the coronavirus with a common cold virus called an adenovirus that won’t make you sick. Since the virus is alive, it can elicit all three kinds of immune responses, Dr. Crotty said.“There are no licensed vaccines right now that use that strategy, but there are all kinds of vaccine trials that have been done around the world with those types [of vaccines] showing that they're straightforward to manufacture. They're very safe,” he said.The University of Oxford is testing a viral vector vaccine for COVID-19 in a Phase 3 clinical trial.Then there are subunit vaccines. These include just a section -- or subunit -- of the virus’ protein.UC San Diego is working on a coronavirus candidate vaccine using this approach.There are subunit vaccines currently on the market for tetanus and other viruses.“Working with proteins is more challenging, just from a laboratory and manufacturing perspective,” Dr. Crotty said.Enter the next phase of vaccine development. Instead of using the virus itself or fragments of it, Inovio Pharmaceuticals is working on a vaccine strategy using just the virus’ genetic information.DNA-based vaccines simply introduce a genetically engineered blueprint of the virus into a person, and the cells do the rest.“Some people get confused about this. They think it’s a genetic vaccine that changes their DNA and becomes part of them, and that’s definitely not the case.” Dr. Crotty said. “They don’t become part of you. Your body chews them up.”Researchers have been working on DNA-based vaccines for about 20 years, Crotty said, but none are currently licensed for use.San Diego-based Arcturus Therapeutics is using an RNA-based approach, along with other companies like Pfizer and Moderna that have entered Phase 3 trials.Messenger RNA reads the DNA instructions and helps translate them into proteins.Dr. Crotty said the DNA and RNA approaches have similar drawbacks and benefits: they’ve never been approved for us, but both can be developed rapidly because they don’t require access to the physical virus.Around the world, there are more than 200 coronavirus vaccines currently in development, according to the Milken Institute. 3459

SAN DIEGO (KGTV) — It has now been seven months since the pandemic began, and there are still a lot of questions about the best ways to treat patients with COVID-19.Researchers at UC San Diego are leading an effort to produce swift and reliable answers that could help doctors tailor treatments and hospitals plan bed space more efficiently.Doctors agree: the best way to fight any disease is to tailor the treatment for each individual based on their age, gender, race and other factors. But how does one doctor do that with a new disease like COVID-19, especially if their hospital has only seen a few hundred cases?“There might be some patterns you can get from 500 patients but there might be some others that you cannot,” said UCSD professor Dr. Lucila Ohno-Machado, chair of the Department of Biomedical Informatics.Dr. Ohno-Machado’s solution? Pool data.She’s leading the charge behind COVID19questions.org, a collaboration between 12 medical systems spanning more than 200 hospitals across the country.The collaboration includes several University of California health systems, the University of Texas Health Science Center at Houston, the University of Colorado Anschutz Medical Campus, and the largest organization in the cohort, the Veterans Affairs Healthcare System.“Each hospital is a little small to answer the questions. So by having it all together, we get the answers quicker,” said Ohno-Machado.They’re going after answers on how long patients with diabetes or cancer stay in the hospital, and whether COVID-19 is deadlier for smokers or non-smokers.Their findings revealed that men are much more likely to wind up on a ventilator than women.And they quantified just how much better we’ve gotten at treating COVID-19 over time.Since May 1, hospital stays among surviving patients have shrunk more than 10 days on average. That’s important for hospital managers planning and predicting bed space.“We decided to open this to the public and to our colleagues, and then we pick which answers have not been answered before and seem to be of most general interest,” Dr. Ohno-Machado explained.If this sounds like a straightforward approach, it’s not. Patient confidentiality laws make it hard for hospitals to share data and the information released by the CDC is limited.Maintaining patient confidentiality while sharing granular data is the most groundbreaking feature of the collaboration, called Reliable Response Data Discovery or known by its Star Wars-inspired acronym, R2D2.UCSD said R2D2 differs from other patient databases and registries because each health system maintains control of data rather than sharing it in a central repository. Through advanced computer techniques, each partner agency shares aggregated data, not patient-level information.The collaboration’s research is based on what’s called “observational data,” so Dr. Ohno-Machado said it’s not a replacement for a randomized, controlled clinical trial, which takes time. She noted their data reflects lessons on hospitalized patients, not everyone infected with the virus.But she said at a time when fast answers can save lives, COVID19questions.org could help. 3161

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