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LOS ANGELES (CNS) - USC researchers have found the likely order in which COVID-19 symptoms first appear: fever, then cough and muscle pain, followed by nausea, and/or vomiting, and diarrhea, it was announced Thursday.Knowing the order of COVID-19's symptoms may help patients seek care promptly or decide sooner than later to self isolate, according to scientists at the USC Michelson Center for Convergent Bioscience. The information also may help doctors rule out other illnesses, or help doctors plan how to treat patients, and perhaps intervene earlier in the disease.The study, which appears in the journal Frontiers in Public Health, was led by doctoral candidate Joseph Larsen and scientists Peter Kuhn and James Hicks at the USC Michelson Center's Convergent Science Institute in Cancer."This order is especially important to know when we have overlapping cycles of illnesses like the flu that coincide with infections of COVID-19," said Kuhn, a USC professor of medicine, biomedical engineering, and aerospace and mechanical engineering. "Doctors can determine what steps to take to care for the patient, and they may prevent the patient's condition from worsening."Fever and cough are frequently associated with a variety of respiratory illnesses, including influenza, Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome. But the timing and symptoms in the upper and lower gastrointestinal tract set COVID-19 apart."Given that there are now better approaches to treatments for COVID- 19, identifying patients earlier could reduce hospitalization time," Larsen said.To determine COVID symptom chronology, the authors analyzed more than 55,000 confirmed coronavirus cases in China collected from Feb. 16 to Feb. 24 by the World Health Organization. They also studied a dataset of nearly 1,100 cases collected from Dec. 11 through Jan. 29 by the China Medical Treatment Expert Group via the National Health Commission of China.In addition, to compare the order of COVID-19 symptoms to influenza, the researchers examined data from 2,470 cases in North America, Europe and the Southern Hemisphere, which were reported to health authorities from 1994 to 1998."The order of the symptoms matter, " Larsen said. "Knowing that each illness progresses differently means that doctors can identify sooner whether someone likely has COVID-19, or another illness, which can help them make better treatment decisions." 2440

LOS ANGELES (CNS) - County public health officials said have ordered the continued closure of LA Apparel's manufacturing facilities in South Los Angeles, announcing that more than 300 workers have been confirmed with the coronavirus and four have died.The company's manufacturing complex on 59th Street was originally closed June 27 after inspectors found "flagrant" violations of infection- control protocols and the company "failed to cooperate" with the county's investigation of what were then about 150 total infections.According to the county Department of Public Health, an official order was issued Thursday mandating the "continuous closure" of the facility.Officials with LA Apparel could not be reached for comment Friday when county officials announced the extended closure."The death of four dedicated garment workers is heartbreaking and tragic," public health director Barbara Ferrer said in a statement. "Business owners and operators have a corporate, moral and social responsibility to their employees and their families to provide a safe work environment that adheres to all of the health officer directives -- this responsibility is important, now more than ever, as we continue to fight this deadly virus."Public health officials said Friday three workers from the plant died in early June, and one more died this month. The agency began investigating conditions at the plant on June 19 after being notified by a "concerned health care provider."According to the department, investigators asked the company for a list of all employees so it could be compared with testing results, but the company failed to provide it.In late June, inspectors found violations at the facility of distancing requirements and infection-control protocols, according to the department, noting that the company was using cardboard as a barrier between workers.On July 4, the company sent the department an "incomplete list" of employees, and by then 198 positive cases had been reported. But as of Friday, that number had risen to more than 300, according to the public health agency.Health officials said that despite the company being ordered closed in late June, LA Apparel reopened the factory with new employees, and company officials tried to prevent health inspectors from entering the facility. 2309

LOS ANGELES (AP) — Hospitals in central and Southern California are quickly running out of intensive care unit beds for coronavirus patients. State officials are poised to extend the strictest stay-at-home orders there as conditions worsen before the post-holiday surge hits. The situation is already dire, and the worst is expected to come in the next few weeks after Christmas and New Year’s travelers return home. California hit 2 million confirmed coronavirus cases on Christmas Eve, becoming the first state to reach the grim milestone. State stay-at-home orders for the San Joaquin Valley and Southern California are set to expire Monday but Gov. Gavin Newsom has signaled they would not be allowed to lapse. 722

LOS ANGELES (AP) — Paul and Jamie Buchman are picking up where they left off 20 years ago on "Mad About You."On-demand service Spectrum Originals said Wednesday a limited series will bring Helen Hunt and Paul Reiser back as the New York City couple.The original series, which aired from 1992 to 1999, followed the Buchmans as newlyweds through early parenthood.The sequel will explore modern marriage from the perspective of empty nesters, Spectrum said. It's set to debut in late 2019.In a statement, Hunt and Reiser promised the same funny, heartwarming show, adding, "as soon as we can remember what's funny about being older."Danny Jacobson, who co-created the show with Reiser, is a consultant.Spectrum Originals is launching this spring with the Gabrielle Union-Jessica Alba drama series "L.A.'s Finest." 818

Looking forward to live sports, but any time I witness a player kneeling during the National Anthem, a sign of great disrespect for our Country and our Flag, the game is over for me!— Donald J. Trump (@realDonaldTrump) July 21, 2020 240