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SAN DIEGO (KGTV) — In the race for a coronavirus vaccine, scientists often say we need more than one winner.That’s in part because different vaccines use different strategies to provoke the immune system, and each strategy has different strengths.Take the inactivated virus vaccine, an approach currently used in the vaccine against the poliovirus. In this approach, scientists take a live virus, kill it with chemicals or heat, and then introduce that viral corpse into a person.There are three groups in the final phase of human trials using inactivated coronavirus, primarily in China, according to a tracker from the Milken Institute.“The immune system can tell the difference between something that's a real threat and something that's not a threat, and so if you get injected with a dead virus your immune system has the tendency to not pay a lot of attention to that,” said Dr. Shane Crotty of the La Jolla Institute for Immunology.The downside of the inactivated virus approach is that it only elicits two out of the three of the parts of the immune system, Dr. Crotty said. It’s capable of producing antibodies and helper T-cells, but not killer T-cells.The modern take on the inactivated virus approach is called a viral vector vaccine.In this strategy, scientists combine elements of the coronavirus with a common cold virus called an adenovirus that won’t make you sick. Since the virus is alive, it can elicit all three kinds of immune responses, Dr. Crotty said.“There are no licensed vaccines right now that use that strategy, but there are all kinds of vaccine trials that have been done around the world with those types [of vaccines] showing that they're straightforward to manufacture. They're very safe,” he said.The University of Oxford is testing a viral vector vaccine for COVID-19 in a Phase 3 clinical trial.Then there are subunit vaccines. These include just a section -- or subunit -- of the virus’ protein.UC San Diego is working on a coronavirus candidate vaccine using this approach.There are subunit vaccines currently on the market for tetanus and other viruses.“Working with proteins is more challenging, just from a laboratory and manufacturing perspective,” Dr. Crotty said.Enter the next phase of vaccine development. Instead of using the virus itself or fragments of it, Inovio Pharmaceuticals is working on a vaccine strategy using just the virus’ genetic information.DNA-based vaccines simply introduce a genetically engineered blueprint of the virus into a person, and the cells do the rest.“Some people get confused about this. They think it’s a genetic vaccine that changes their DNA and becomes part of them, and that’s definitely not the case.” Dr. Crotty said. “They don’t become part of you. Your body chews them up.”Researchers have been working on DNA-based vaccines for about 20 years, Crotty said, but none are currently licensed for use.San Diego-based Arcturus Therapeutics is using an RNA-based approach, along with other companies like Pfizer and Moderna that have entered Phase 3 trials.Messenger RNA reads the DNA instructions and helps translate them into proteins.Dr. Crotty said the DNA and RNA approaches have similar drawbacks and benefits: they’ve never been approved for us, but both can be developed rapidly because they don’t require access to the physical virus.Around the world, there are more than 200 coronavirus vaccines currently in development, according to the Milken Institute. 3459
SAN DIEGO (KGTV) — Included in the new defense budget bill just passed by Congress is what some call the most sweeping military housing reforms in decades. However, San Diego military families are concerned that a loophole will allow the private companies that oversee the housing developments to continue ignoring what they call "slum" conditions.10News has been digging for months into the problems reported by residents at local communities run by Lincoln Military Housing, one of the biggest companies in the industry. Residents say they have been plagued by mold, which has caused illness, as well as rodent and insect infestations, and shoddy maintenance and repairs.RELATED: .7 million awarded to Housing Commission to house military veterans"Lincoln Military Housing doesn't do a very good job of maintaining the infrastructure of these homes," says resident Erika Bradley.Bradley says the recent storms have led to more problems with leaks and mold. She says around 50 families living in the Santo Terrace community in Tierrasanta were forced to leave their homes and move into hotels.The new deal agreed to by Congress include the framework of significant reforms, including a tenant bill of rights, a strict set of regulations for how complaints should be handled, and an arbitration process that leaves the final decision in the hand of base commanders, rather than the companies. RELATED: Marine Corps family wins lawsuit against Lincoln Military Housing, after kids sickened by moldHowever, the language in the bill appears to indicate that the companies will not be forced to sign on to the new processes, making them voluntary. While the military and Congress can use the failure to agree to the processes as grounds to decide not to renew the contract with a company, most of the housing companies have long-term deals in place. That means it's possible that it could be nearly 30 years before some of them would be forced to consider making changes."It's kind of something that looks really good on paper," Bradley says, "but how does it actually help us in our day to day lives?"10News asked if Lincoln plans to agree to the new procedures. A spokesperson responded that the company is reviewing the provisions passed by Congress. RELATED: Navy takes action on complaints of mold, rats in military housingIn a statement to 10News, she said "Lincoln Military Housing, along with our military partners, have instituted a series of reforms to improve service for military families. We will continue to work with our partners on ways we can continue to improve service and strengthen the program.” 10News also reached out to Congresswoman Susan Davis and Senator Dianne Feinstein, who have both worked on military housing issues. Neither was available for an interview. 2794

SAN DIEGO (KGTV) – It's exploding in the wellness industry, but is CBD safe? 10News visited a San Diego lab that tested CBD products for ingredients like pesticides and heavy metals. The results were surprising to lab personnel. Shelby Huffaker is the lead cannabis educator at Torrey Holistics in Sorrento Valley. The licensed dispensary recently conducted its own CBD study to show customers just how unreliable the open market can be. "We collected about a dozen different products from various locations around San Diego and also on the internet," she tells 10News. Torrey Holistics collected samples from places like farmers' markets, grocery stores, and the internet. The company bought CBD products such as lip balms, caramels, creams, and bath bombs, then sent to San Diego's Infinite Chemical Analysis Labs. "It's pretty busy right now with it being harvest time," says David Marelius, Ph.D. He's the co-founder of Infinite Chemical Analysis Labs, which tests cannabis and related products. "People are definitely trying to take advantage of the CBD boom right now," he adds. Both CBD and THC come from the cannabis plant, but CBD does not have the psychoactive properties that give you the feeling of being high. CBD received praised for claims of health benefits like reducing anxiety and inflammation. According to Infinite Chemical Analysis Labs, none of the CBD samples purchased on the internet by Torrey Holistics had any CBD in them. Dr. Marelius tells 10News that the majority of the overall samples didn't meet their packaging claims. He adds that the products' potencies were off, and one product had almost 70% less CBD in it than what it advertised. Three of the products reportedly failed for pesticides, although the levels were so low that they likely weren't harmful. "It's kind of the wild west out there," says Sally Greenberg with the National Consumers League. Greenberg tells 10News that CBD sellers often exaggerate the benefits of CBD without having the science to back up the claims. "[They say] that they cure cancer or treat Alzheimer's or treat AIDS," she adds. The National Consumers League is advocating for federal oversight from the Food and Drug Administration, which currently doesn't regulate most CBD. In California, the Bureau of Cannabis Control tests CBD that's sold in licensed dispensaries, like Torrey Holistics. "You're going to want to look for a Batch number or UID number. That ensures that we're able to match the testing results with that specific product," says Huffaker. The dispensary is hoping that the lab results will highlight the importance of researching your CBD before buying. "Everything carried in a licensed cannabis store is going to have to be verified [and] vetted by the dispensary [to be sure] it has gone through the necessary testing," adds Huffaker. The state's Bureau of Cannabis Control has a search function on its website where you can see what licensed dispensaries are in your area, or you can search a dispensary to be sure its licensed. Click here. 3048
SAN DIEGO (KGTV) — Maverick has landed in San Diego!Eagle-eyed fans caught glimpses of actor Tom Cruise in Coronado Monday, on the set of the upcoming "Top Gun" sequel, "Top Gun: Maverick." The 56-year-old actor was spotted on a motorcycle (again) near the entrance of Naval Base Coronado by media and residents. But it's not a total surprise, as many were alerted to the possibility of filming last week, when the city posted "no parking" signs outside the base.RELATED: 500
SAN DIEGO (KGTV) -- Local agencies voiced their support for the two Los Angeles County Deputies were ambushed and shot while sitting in their patrol car Saturday night.The San Diego County Sheriff’s Department shared a message of solidarity on Twitter late Saturday night, saying department staff are sending thoughts and prayers.The San Diego Police Department and San Diego FBI also reacted to the shooting.All of us at @SDSheriff send our thoughts and prayers to @LASDHQ after two of their deputies were shot in the line of duty. https://t.co/n7eQHs9eUc— San Diego Sheriff (@SDSheriff) September 13, 2020 Tonight, our thoughts and prayers are with @LASDHQ as two of their deputies are fighting for their lives. The two deputies sustained multiple gunshot wounds in an ambush attack as they sat in their patrol vehicle. https://t.co/JXtgtF1wkw— San Diego Police Department (@SanDiegoPD) September 13, 2020 The FBI San Diego Division stands in solidarity with the Los Angeles County Sheriff's Department tonight. Two of their deputies are fighting for their lives after being shot in an ambush tonight. @LASDHQ https://t.co/elvH9SzNaU— FBI San Diego (@FBISanDiego) September 13, 2020 RELATED: Two Los Angeles Sheriff's deputies shot in ambush attack at Compton train stationThe 31-year-old female deputy and 24-year-old male deputy were shot as they sat inside their patrol vehicle just before 7 p.m. at the Metro Blue Line station in Compton.Authorities in LA said both deputies were rushed to the hospital with multiple gunshot wounds. Both deputies are in critical condition, the department said.Video shows the suspect approaching the deputies from behind the vehicle before walking along the passenger side, raising a pistol, and opening on fire.The shooting also sparked a protest outside the hospital where the deputies were taken. Authorities said on Twitter that demonstrators shouted “we hope they die.” 1922
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