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SAN DIEGO (CNS) - An international team of scientists, led by biologists at the University of California San Diego, has synthetically engineered mosquitoes that halt the transmission of the dengue virus, the university announced Thursday.Scientists at UC San Diego Associate Professor Omar Akbari's lab worked with Vanderbilt University Medical Center to identify a human antibody for dengue suppression. The broad-spectrum antibody stops the transmission of all four known types of the fever, compared to previous experiments, which have been able to limit single strains.The team then designed the antibody "cargo" to be synthetically expressed in the dengue-spreading Aedes aegypti mosquitoes.RELATED: UC San Diego study finds solutions for loneliness"Once the female mosquito takes in blood, the antibody is activated and expressed -- that's the trigger," Akbari said. "The antibody is able to hinder the replication of the virus and prevent its dissemination throughout the mosquito, which then prevents its transmission to humans. It's a powerful approach."Akbari works in the Division of Biological Sciences and is a member of the Tata Institute for Genetics and Society.These lab-engineers mosquitoes could be paired with a dissemination system, making it capable of spreading the antibody throughout wild disease- transmitting mosquitoes, Akbari said.Dengue fever is a virus that poses a severe risk to children and older adults in tropical regions in Asia and Latin America. There are an estimated 390 million infections every year, around 500,000 of which lead to Severe Dengue, and 25,000 people die of the disease every year.RELATED: UCSD Health, San Diego Zoo Safari Park team up to save gorilla's eyesightThe Pan American Health Organization recently reported the highest number of dengue cases ever recorded in the Americas. Infecting those with compromised immune systems, dengue victims suffer flu-like symptoms, including severe fevers and rashes. Serious cases can include life-threatening bleeding. No specific treatment exists and thus, prevention and control depend on measures that stop the spread of the virus.This development could go a long way toward limiting the disease's transmission."It is fascinating that we now can transfer genes from the human immune system to confer immunity to mosquitoes," said coauthor of the paper, Dr. James Crowe, Jr., director of the Vanderbilt Vaccine Center at Vanderbilt University Medical Center in Nashville, Tenn. "This work opens up a whole new field of biotechnology possibilities to interrupt mosquito-borne diseases of man."Akbari's lab is now in the early stages of testing methods to simultaneously neutralize mosquitoes against dengue and a suite of other viruses such as Zika, yellow fever and chikungunya. 2789
SAN DIEGO (CNS) - A man who was previously acquitted of a 12-year-old Escondido girl's murder was released from county jail this week, months after he was charged with being a felon at a county jail.Richard Raymond Tuite, 51, was released Thursday after a judge set his bail at SAN DIEGO (CNS) - A wrongful death lawsuit was filed Monday on behalf of the family of a 24-year-old woman who died last fall at the Las Colinas Detention Facility in Santee.Elisa Serna died Nov. 11, 2019, a few days after she was booked into the county jail.Earlier this year, the sheriff's department said Serna died from complications of drug abuse, with a contributing factor of early intrauterine pregnancy.The lawsuit filed in San Diego federal court alleges jail staff were aware of Serna's substance abuse and subsequent withdrawal symptoms, but did not provide her with treatment. Though Serna was fainting, had low blood pressure, was vomiting regularly and displaying odd and incoherent behavior, jail staff "ignored the obvious signs of medical distress" and "failed to provide proper medication as Elisa's condition was worsening," the complaint alleges.Sheriff's officials could not immediately be reached for comment on the suit, which names San Diego County and Sheriff Bill Gore as defendants.Plaintiffs in the suit include Serna's parents, Michael and Paloma Serna; her husband, Brandon Honeycutt, and a minor child referred to as S.H.The sheriff's department has come under fire recently over a spate of deaths among county jail inmates, which were referenced within the complaint.The lawsuit cited news reports indicating the county had the highest jail mortality rate among the state's largest counties, and said prior deaths from inmates suffering from withdrawal symptoms should have made jail staff aware of the potentially fatal consequences of those symptoms.The suit also alleges staff are inadequately trained and in-custody deaths at county jails are not being properly investigated."Even though inmates are dying or suffering catastrophic injuries at an alarming rate at San Diego County jails, the medical and correctional staff whose actions or inactions cause the deaths are not investigated; not informed of their failures; not given further training or remedial instruction; and are not monitored or closely supervised after these adverse events," the lawsuit alleges. 2111 for a single felony count of being an ex-con on prison grounds or adjacent lands, one of several offenses now being set at SAN DIEGO (CNS) -- Fleets of skywriting planes will leave artist-created messages in San Diego, Los Angeles and Orange County skies Friday above immigration detention centers, courts and historically significant landmarks in an effort to call attention to the detention of immigrants.Starting at about 9:30 a.m. above the Adelanto Detention Center, the fleet will travel to downtown Los Angeles skies, where 15-character messages will be left in the late morning airspace above immigration facilities, county and federal lockups and courthouses, followed by the Arcadia and Pomona locations of internment camps where Japanese Americans where held during World War II.In the afternoon, the planes will start at Terminal Island at about 1:45 p.m. and travel to Orange County and San Diego, where messages will be left above courts and immigration offices, with a 3 p.m. finish in the skyways above the Otay Mesa Immigration Court.Producers of the event said the goal of the skywriting performance, in which 80 artists have contributed across the country over the Independence Day weekend, is "to make visible what is too often unseen and unspoken -- the imprisonment of immigrants."Written with water vapor, the messages are designed to be seen and read for miles."We wanted to devise the sort of display that would make visible the problem of immigrant detention," said Los Angeles-based performance artist Cassils, co-founder of the nationwide project. "By going over the internment camps, we want to make clear that the problem is nothing new."Each artist's message will end in #XMAP, a hashtag devised to lead viewers to In Plain Sight, a website and interactive map which locates the U.S. Immigration and Customs Enforcement detention facilities within the viewer's immediate vicinity.Los Angeles artist contributors include Black Lives Matter co-founder Patrisse Cullors, whose words, "CARE NOT CAGES," will be written in the clouds above LA County Jail, the largest such facility in the country.Latina transgender organizer and advocate Bamby Salcedo's message, "STOP CRIMIGRATION NOW," will be projected above U.S. Citizenship and Immigration Services' downtown field office.Cassils' phrase, "SHAME #DEFUNDHATE," will be affixed over the Los Angeles-area headquarters of the Geo Group, operators of for-profit prisons.Until prisons and detention facilities are abolished, "we will fight to end the symptoms of racist law enforcement and brutality," said Tania Bernal of the California Immigrant Youth Justice Alliance, adding that she hopes to show that "even those most deemed disposable by the state are worthy of their humanity, of compassion, and of transformational growth." 2693 bail in an effort to reduce jail populations since the COVID-19 pandemic began.He was charged in January for allegedly being at a corrections facility while having prior convictions that include burglary, bribery and escape from a jail. Details on why Tuite was at the jail remain unclear.RELATED: Investigation: Who killed Stephanie Crowe?Tuite had been in custody since January following the arrest, and his criminal case was recently reinstated after he was previously found mentally incompetent to stand trial. He's due back in court Sept. 24 for a preliminary hearing.Tuite was previously convicted of voluntary manslaughter and sentenced to 13 years in state prison in the well-publicized case regarding the stabbing death of seventh-grader Stephanie Crowe, but his conviction was later overturned and he was acquitted in a 2013 retrial.Crowe's body was found sprawled in the doorway of her bedroom by her grandmother early on the morning of Jan. 21, 1998. She had been stabbed nine times.Her older brother, Michael, and two of his friends, Aaron Houser and Joshua Treadway, initially were accused of committing the murder, and police extracted confessions from two of them during lengthy interrogations.The admissions were later ruled to have been coerced, and the charges against the boys were dismissed. During Tuite's retrial, the now-adult former suspects testified that they had no involvement in Stephanie's death.Tuite had been in the area of the Crowe residence the night the girl was killed. He was agitated and looking for a woman named Tracy, according to prosecutors, who contended that the disheveled and seemingly confused transient wandered into the Crowe home and attacked the girl.Investigators, however, found no physical evidence directly linking him to the crime scene.Analysts later found the victim's blood on two shirts that Tuite had been wearing on the day of the murder. Jurors who voted to acquit Tuite said they believed a defense theory of "contamination," in which blood from the crime scene somehow wound up transferred onto Tuite's clothing.More than two decades after the murder, two families reacted Friday after Tuite was released in the current case."I'm absolutely pleased. He is not a danger to anyone and doesn't belong in jail," said Tuite's sister, Kerry Licon."Richard Tuite, free, walking the streets after murdering my child, is our family's daily struggle to cope with. The absence of integrity, common sense - mixed in with qualified immunity - isn't just worrisome for us. It is a threat to everyone's safety!" said Stephanie's mother, Cheryl Crowe. 3019

SAN DIEGO (CNS) - A western harvest mouse found in Escondido tested positive for the potentially deadly hantavirus, San Diego County Vector Control officials announced Friday.The mouse was found during routine monitoring of the area. Since January, Vector Control has collected multiple mice that have tested positive for the virus in areas of north and east county, including Julian, Fallbrook, Bonsall, Boulevard, 4S Ranch, Warner Springs and Potrero.With each instance, county officials have reminded residents to avoid sweeping or vacuuming rodent droppings, which can push the virus into the air. Instead, residents are advised to use so-called "wet cleaning" methods like a diluted bleach spray, disinfectants or a sponge and a mop to clean up wild rodent matter like urine, feces and saliva. Cleansed areas should also remain well-ventilated to ensure the virus does not linger.RELATED:Three cases of tuberculosis reported in San Diego CountyThird patient dies of flu this season in San DiegoGoogle is collecting health data on millions of AmericansHantavirus is not uncommon in San Diego County's rural and undeveloped areas, but residents can avoid exposure by keeping rodents out of their homes, sheds and garages, according to Vector Control. Wild mice, in particular, are the virus' main carriers.There is no cure or vaccine for hantavirus, which can cause deadly infections. According to the Centers for Disease Control and Prevention, symptoms of infection can include fever, aches in the large muscle groups, dizziness, digestive issues and abdominal pain.Residents can prevent exposure to hantavirus by sealing holes larger than a dime and quickly disposing of rodent debris in homes and adjacent structures.The county's Department of Environmental Health can be reached at 858- 694-2888 for more information about avoiding hantavirus exposure and infection. In addition, residents can find more information on the virus here. 1950
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来源:资阳报