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LONDON (AP) — Oxford University says trials of a coronavirus vaccine that it is developing with pharmaceutical company AstraZeneca will resume, days after being paused due to a reported side-effect in a patient in the U.K. The university said in large trials such as this “it is expected that some participants will become unwell and every case must be carefully evaluated to ensure careful assessment of safety.” It said globally 18,000 people have received the vaccine so far. Oxford insisted that it is “committed to the safety of our participants.” Pauses in drug trials are commonplace. The Oxford-AstraZeneca vaccine is seen as one of the strongest contenders among the dozens of coronavirus vaccines being tested. 728

LOS ANGELES (CNS) - Adult film star Ron Jeremy pleaded not guilty Monday to 20 additional rape and other sexual assault charges involving 12 more women and a teenage girl in attacks dating back to 2004, bringing the number of his alleged victims to 17.In June, Jeremy, 67, entered a not guilty plea in response to allegations that he raped three women and sexually assaulted another in separate attacks going back to 2014.The District Attorney's Office amended the complaint Monday against the defendant -- whose real name is Ronald Jeremy Hyatt -- to include a total of eight forcible rapes and lewd conduct with a 15-year-old girl, among other counts.Jeremy is being held in lieu of .6 million bail, despite an earlier defense request to lower the amount, and was ordered back to court Oct. 28, when a date is expected to be set for a preliminary hearing.If convicted on all counts, the porn star could face up to 250 years to life in prison.Prosecutors said the victims range in age from 15 to 54 and that the teen was assaulted at a party she attended in Santa Clarita. The most recent allegation was made by a 21-year-old woman who alleged that Jeremy sexually assaulted her on New Year's Day outside a business in Hollywood.A half-dozen of the other alleged assaults happened inside a West Hollywood bar the defendant frequented and another took place in the bar's parking lot, according to prosecutors.The defendant is accused of raping a 25-year-old woman at a home in West Hollywood in May 2014. He is also charged with raping a 33-year-old woman and sexually assaulting a 46-year-old woman on separate occasions at a West Hollywood bar in 2017 and raping a 30-year-old woman at the same bar last July, according to the Los Angeles County District Attorney's Office.The amended charges include eight counts of forcible rape, seven counts of sexual battery by restraint, four counts of forcible oral copulation, three counts of sexual penetration by use of force and one count each of sodomy, assault with intent to commit rape, sexual penetration by anesthesia or controlled substance, sexual penetration by a foreign object, sexual penetration on an unconscious or sleeping victim and lewd conduct with a minor.The Los Angeles County Sheriff's Department said the case stemmed from a two-year investigation. 2327

LOS ANGELES (AP) — A former business manager of Stan Lee was arrested Saturday on elder abuse charges involving the late comic book legend.Keya Morgan was taken into custody in Arizona on an outstanding arrest warrant after being charged by Los Angeles County prosecutors earlier this month.Morgan faces felony charges including theft, embezzlement, forgery or fraud against an elder adult, and false imprisonment of an elder adult. A misdemeanor count also alleges elder abuse.Authorities say Morgan sought to capitalize on the Marvel Comic mastermind's wealth and exert influence over Lee even though he had no authority to act on his behalf.Police say Morgan pocketed more than 2,000 from autograph signing sessions Lee did in May 2018. Authorities say Morgan at one point also took Lee from his Hollywood Hills home to a Beverly Hills condominium "where Morgan had more control over Lee."Lee's daughter said in a request for a restraining order last year that Morgan was manipulating the mentally declining Lee, preventing him from seeing family and friends, and trying to take control of his money and business affairs.Attorney Alex Kessel has said Morgan has never abused or taken advantage of Lee. Kessel said in an email on Saturday that he had been in contact with prosecutors to arrange for Morgan to surrender on Tuesday."It is unfortunate that the DA and police did not honor our commitment to surrender next week and arrested him," Kessel said in an email.Lee died in November at the age of 95.Morgan's bail has been set at 0,000. He will eventually be extradited to Los Angeles to face the charges. 1626

LOS ANGELES — California has become the first U.S. state to record 2 million confirmed coronavirus cases.A tally by Johns Hopkins University on Thursday morning showed the nation’s most populous state has a total of 2,010,157 infections. There have been more than 23,000 deaths.The grim milestone comes as the COVID-19 crisis that health officials say stems from Thanksgiving gatherings strains California’s medical system. More than 18,000 people are hospitalized and many of the state’s intensive care units are filled. Mobile field hospitals are being erected in several places around California to handle the overflow of patients. The California Department of Public Health this week declared that the two Southern California regions, encompassing Los Angeles, San Diego, Fresno, Bakersfield and the San Joaquin Valley had 0% ICU bed availability. 859

LOS ANGELES (AP) — Georgia Engel, who played the charmingly innocent, small-voiced Georgette on "The Mary Tyler Moore Show" and amassed a string of other TV and stage credits, has died. She was 70.Engel died Friday in Princeton, New Jersey, said her friend and executor, John Quilty. The cause of death was unknown because she was a Christian Scientist and didn't see doctors, Quilty said Monday.Engel was best known for her role as Georgette on "The Mary Tyler Moore Show," whose character was improbably destined to marry pompous anchorman Ted Baxter, played by Ted Knight.Engel also had recurring roles on "Everybody Loves Raymond" and "Hot in Cleveland." She was a five-time Emmy nominee, receiving two nods for the late Moore's show and three for "Everybody Loves Raymond."Engel's prolific career included guest appearances on a variety of shows, including "The Love Boat," ''Fantasy Island," ''Coach" and "Two and a Half Men." Her "Hot in Cleveland" role reunited her with Betty White, her co-star in "The Mary Tyler Moore Show."She appeared on Broadway in plays and musicals including "Hello, Dolly!", "The Boys from Syracuse" and, most recently, "The Drowsey Chaperone" in 2006-07.Engel's final credited television appearance came last year in the Netflix series "One Day at a Time." 1299