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Pfizer announced Friday that it would submit a request to the FDA Friday for its COVID-19 vaccine to be granted Emergency Use Authorization.Earlier this week, Pfizer said that a final analysis of trial results showed the vaccine is 95% effective.“Our work to deliver a safe and effective vaccine has never been more urgent, as we continue to see an alarming rise in the number of cases of COVID-19 globally. Filing in the U.S. represents a critical milestone in our journey to deliver a COVID-19 vaccine to the world and we now have a more complete picture of both the efficacy and safety profile of our vaccine, giving us confidence in its potential,” Dr. Albert Bourla, Pfizer Chairman and CEO, said in a press release.Pfizer's two-shot vaccine has already been in mass production for months, and thousands of doses will be ready for delivery if and when the FDA grants authorization. Pfizer says that is on track to produce 50 million doses of the vaccine by the end of 2020 and plans to produce 1.3 billion doses of the vaccine in 2021.According to "Operation Warp Speed," the federal government's plan for distributing the vaccine, upon authorization, the drug will initially be rationed for high-risk populations and health care workers. Dr. Anthony Fauci, the nation's top infectious disease expert, says he believes a vaccine won't be widely available until April.On Wednesday, Pfizer announced that a final analysis of its vaccine candidate showed that of 40,000 participants who participated in the trial, 170 people had contracted the virus. Of those 170 people, 162 received only a placebo injection — meaning just eight out of the 20,000 people who actually received the vaccine contracted the virus.The company added Wednesday that there have been no safety concerns with the vaccine. In a randomized survey of 8,000 participants, only 2% reported suffering severe fatigue, and only 4% reported suffering severe headaches. Those who say they suffered side effects only experienced them briefly after vaccination.Pfizer's announcement comes as COVID-19 cases are spiking around the world. In the U.S. alone, about 2.5 million people have contracted the virus in the month of November alone. Hospitalizations linked to COVID-19 are at an all-time high, and deaths have begun to tick up in recent weeks. 2322

PALM BEACH COUNTY, Fla. — As the coronavirus continues to grip parts of South Florida, there are growing concerns over hospitalizations and the numbers of intensive care unit beds available.Last week the Sunshine State hit another grim milestone with more than 1,800 hospitalizations — the highest in a single day since the start of the pandemic, according to state records.Many hospitals are taking action against the record-setting numbers.Some hospitals in the state, including Bethesda East, Bethesda West and Boca Raton Regional Center in South Florida, are now rescheduling elective procedures that require overnight stays to help free up space.In Florida, 56 hospital ICUs have hit capacity and another 35 hospitals show ICU bed availability of 10% or less.As of Wednesday morning, many Palm Beach County hospital ICUs were reportedly near capacity.Florida Gov. Ron Desantis said hospitals are seeing more patients who are coming in for other reasons and then learning they have COVID-19. He added that is part of the reason the positive numbers are rising."People didn't all of the sudden stop having heart attacks," DeSantis said. "People were not as comfortable seeking medical care then, so we've been stressing, and every hospital we've talked to is stressing, hey, we're open for business."To check ICU bed availability throughout Florida, click here.This story was originally published by Kamrel Eppinger on WPTV in Palm Beach, Florida. 1458

PARADISE, Calif. (AP) — Authorities called in a mobile DNA lab and anthropologists to help identify the dead as the search went on for victims of the most destructive wildfire in California history. The overall death toll from the outbreak of fires at both ends of the state stood at 25 Sunday and appeared likely to rise.All told, more than 8,000 firefighters battled three large wildfires burning across nearly 400 square miles (1,040 square kilometers) in Northern and Southern California, with out-of-state crews continuing to arrive and gusty, blowtorch winds forecast into Monday.The worst of the blazes was in Northern California, where flames reduced the town of Paradise, population 27,000, to a smoking ruin days ago and continued to rage in surrounding communities. The number of people killed in that fire alone, at least 23, made it the third-deadliest on record in the state.LIVE BLOG: Wildfires burning in CaliforniaButte County Sheriff Kory Honea said the county was bringing in more rescue workers and consulted anthropologists from California State University at Chico because in some cases "the only remains we are able to find are bones or bone fragments.""This weighs heavy on all of us," Honea said.Authorities were also bringing in a DNA lab and encouraged people with missing relatives to submit samples to aid in identifying the dead after the blaze destroyed more than 6,700 buildings, nearly all of them homes.The sheriff's department compiled a list of 110 people unaccounted for, but officials held out hope that many were safe but had no cellphones or some other way to contact loved ones.RELATED: Sheriff: 110 people missing in NorCal fireFirefighters gained modest ground overnight against the blaze, which grew slightly to 170 square miles (440 square kilometers) from the day before but was 25 percent contained, up from 20 percent, according to state fire agency, Cal Fire.But Cal Fire spokesman Bill Murphy warned that gusty winds predicted into Monday morning could spark "explosive fire behavior."Two people were also found dead in a wildfire in Southern California , where flames tore through Malibu mansions and homes in working-class Los Angeles suburbs. The severely burned bodies were discovered in a long residential driveway in Malibu, home to a multitude of Hollywood celebrities.Among those forced out of their homes were Lady Gaga, Kim Kardashian West, Guillermo del Toro and Martin Sheen.Flames also raged on both sides of Thousand Oaks, the Southern California city still in mourning over the massacre of 12 people in a shooting rampage at a country music bar Wednesday night.Fire officials said Sunday morning that the larger of the region's two fires, the one in and around Malibu, grew to 130 square miles (337 square kilometers) and was 10 percent contained. But firefighters braced for another round of Santa Ana winds, the powerful, dry gusts that blow out of the interior toward the coast.The count of lost structures in both Southern California fires climbed to nearly 180, authorities said.All told, a quarter-million people were under evacuation orders up and down the state.Gov. Jerry Brown said he is requesting a major-disaster declaration from President Donald Trump that would make victims eligible for crisis counseling, housing and unemployment help, and legal aid.Drought, warmer weather attributed to climate change and home construction deeper into forests have led to more destructive wildfire seasons in California that have been starting earlier and lasting longer.California emerged from a five-year drought last year but has had a very dry 2018. Much of the northern two-thirds of the state is abnormally dry.In Paradise, a town founded in the 1800s, residents who stayed behind to try to save their properties or who managed to return despite an evacuation order found incinerated cars and homes.Wearing masks because the air was still heavy with smoke, people sidestepped metal that had melted off of cars or Jet-Skis as they surveyed their ravaged neighborhoods. Some cried when they saw nothing was left.Jan McGregor, 81, got back to his small two-bedroom home in Paradise with the help of his firefighter grandson. He found his home leveled — a large metal safe and pipes from his septic system the only recognizable traces. The safe was punctured with bullet holes from guns inside that went off in the scorching heat.He lived in Paradise for nearly 80 years, moving there in 1939, when the town had just 3,000 people and was nicknamed Poverty Ridge."We knew Paradise was a prime target for forest fire over the years," he said. "We've had 'em come right up to the city limits — oh, yeah — but nothing like this."McGregor said he probably would not rebuild: "I have nothing here to go back to."___This story has been corrected to fix survivor's name to McGregor instead of MacGregor.___Associated Press writers Daisy Nguyen, Olga R. Rodriguez and Sudhin Thanawala in San Francisco contributed to this report. Darlene Superville contributed from Paris. 5055

Owning a vehicle, or even renting one, can be very costly. But there's a company, referred as the Airbnb of cars, that claims to help you make and save money.The California-based company Turo is a peer-to-peer carsharing service. Christie and her husband heard about the online car rental service two years ago. With having to care for three children, they decided it was time to make some extra cash, so they posted their car for rent on Turo. "It's really just posting pictures of your car, and they set you up with a photographer if you want professional pictures done of your car," explains Christie.Depending on how new and nice your vehicle is, Christie says Turo allows you to price your car accordingly. Her Jeep Wrangler rents for 9 a day. At first, Christie says they raked in about 0 a month, which was just enough to pay the car payment. But as they got more reviews from renters, they were making enough to supplement an income. "I would say our profit, 0 at least," says Christie. "During the summer months, it can be up to ,400 in profit."Making that kind of money is great. But, Christie says there are a few sacrifices you have to be willing to make. "If somebody books last minute, it's kind of being able to rearrange my schedule to be able to meet them."A majority of the time, Christie has to drive 30 minutes to the airport to drop the car off with the renter at the airport. Another downside: a lot of miles have been put on her car. She says in just two years, renters have put 51,000 miles on her Jeep. Not only does Christie rent out her car, but she has actually rented a car through Turo while on vacation in Saint Louis. She says her family was on a tight budget. They found a compact car for 0 for an entire week.If she went through a well-known national car rental service, it would have cost her around 1 a week. She saved 1 by renting through Turo. When Christie meets a renter, she checks their driver's license and gives them the keys. It's that simple and easy to use.  2143

Philadelphia is the most populous city in a battleground state, and there is a lot of attention being paid to its polling locations Tuesday. Of the 25 complaints of potential polling place or Election Day concerns the Philadelphia District Attorney’s Office received by noon ET on Tuesday, 21 were already resolved.In a press release, they said the vast majority of complaints were about alleged interference, like a polling place being partially blocked by construction or members of the press.The Philadelphia District Attorney responded on social media to a concern shared by Trump’s Election Day operations director.“Members of our Election Task Force have investigated this allegation. This polling place is located in an interior room and the sign in question is further than 10 feet from it. This tweet is deliberately deceptive,” the district attorney’s official Twitter account stated. 902

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