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A third leading candidate COVID-19 vaccine has entered a final stage of human testing in the United States. AstraZeneca announced Monday its potential COVID-19 vaccine has entered final trials in the U.S. to test the effectiveness and safety of the product. The Cambridge, England-based company said the trial will involve up to 30,000 adults from various racial, ethnic and geographic groups. The potential vaccine was invented by the University of Oxford and an associated company, Vaccitech.AstraZeneca said development of the vaccine known as AZD1222 is moving ahead globally with late-stage trials in the U.K., Brazil and South Africa. Further trials are planned in Japan and Russia.“To have just one vaccine enter the final stage of trials eight months after discovering a virus would be a remarkable achievement; to have three at that point with more on the way is extraordinary,” Health and Human Services Secretary Alex Azar said in a statement.Two other vaccine candidates began final testing this summer in tens of thousands of people in the U.S. One was created by the National Institutes of Health and manufactured by Moderna Inc., and the other developed by Pfizer Inc. and Germany’s BioNTech. 1215

A US advisory panel has released their recommendations on how a future COVID-19 vaccine should be distributed, and is now seeking public comments on their draft plan.The National Academies of Science, Engineering and Medicine published their discussion draft Tuesday afternoon on their website. It is meant to “assist policymakers in planning for equitable allocation of a vaccine against COVID-19.”The draft plan has a four-phased approach to handle the intense demand for and limited supply of the vaccine when it is first developed.“While major efforts are being made to have a significant supply of COVID-19 vaccine as soon as possible, the committee has been tasked with considering the tough choices that will need to be made for allocating the tightly constrained initial supplies,” said committee co-chair Helene Gayle, president and CEO of the Chicago Community TrustThe plan states in the first phase “would be ‘frontline’ health workers—health professionals who are involved in direct patient care, as well as those in transport, environmental services staff, or other health care facility services, who risk exposure to bodily fluids or aerosols. Under conditions of such scarcity, access should not be defined by professional title, but rather by the individual’s actual risk of exposure to COVID-19.”Their plan also gives higher priority to older Americans living in group settings. They cite data showing about 80 percent of all COVID-19 deaths in the US occurred in people over the age of 65, and a significant proportion of them were people living in long-term care facilities.“Recognizing the importance of education and child development,” tier 2 includes teachers and school staff, as well as those with pre-existing conditions that put them at a heightened risk of severe complications from COVID-19 and those living in group housing situations not included in tier 1.The group states that by the time there is enough of the vaccine to reach tier 4, “ideally, these individuals would be willing to participate in an egalitarian process (such as a lottery) if there are persistent local or regional shortages in this phase.”The group that developed this draft was formed in July at the request of the National Institutes of Health and the Centers for Disease Control and Prevention.“We are pleased to help inform the government’s decision-making process and provide our expert advice for priority-setting for the equitable allocation of potential COVID-19 vaccines,” said National Academy of Medicine President Victor J. Dzau. “Input from the public on this draft framework, especially from communities disproportionately affected by COVID-19, is essential to produce a final report that is objective, balanced, and inclusive.”The public comment period will be open until 11:59 p.m. on Friday, September 4. Commenters will be able to download and review the draft before submitting a comment at nationalacademies.org/VaccineAllocationComment.A final recommendation will be published this fall to include any changes following public comment. 3069

A small sinkhole opened in the White House lawn on Tuesday, causing a section of the lawn to be roped off. The sinkhole is in the north lawn of the White House. White House groundskeepers placed a wooden board over the sinkhole.  247

A suburban Atlanta police officer resigned after his department said he used foul language and inappropriate tactics during the arrest of a 65-year-old grandmother during a traffic stop, recorded on a police dashboard camera.Alpharetta Officer James Legg had been called in as backup during a May 4 traffic stop because the Lyft driver would not sign a ticket and refused another officer's order to get out of her car, officials said.In a letter to Alpharetta Public Safety Director John Robison released Friday, Legg said he felt he behaved appropriately and followed his training."I judged her actions to be passive resistance and used very limited force to end a multiple minute encounter with the suspect," he said. "Maybe I should not have used profanity, but its immediate effectiveness is not questionable and I do believe I acted reasonably under the circumstances."Dashcam video showed Legg pointing at the driver and shouting, "You're not in charge. Shut the f---- up and get out of the car." 1010

A month ago, a former student roamed the halls of Marjory Stoneman Douglas High, opening fire on terrified students and teachers at the Florida school.The massacre of 17 students and faculty members added to a grim statistic: three of the 10 deadliest mass shootings in modern US history happened within five months of one another. In the four weeks since the Valentine's Day shooting, the survivors have turned into activists on the national stage. Even as they grieve, they've demanded action on gun reform. In between congressional meetings and protests, they've attended memorials and funerals. 606