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The US Food and Drug Administration approved Janssen Pharmaceuticals Inc.'s esketamine on Tuesday for treatment-resistant depression; the drug is the chemical cousin of ketamine, the powerful anesthetic that has been used illegally as the club drug Special K.It will be sold as Spravato. More specifically, it's for patients who have tried at least two other medications without success, and it should be taken with an oral antidepressant."There has been a longstanding need for additional effective treatments for treatment-resistant depression, a serious and life-threatening condition," Dr. Tiffany Farchione, acting director of the Division of Psychiatry Products at the FDA's Center for Drug Evaluation and Research, said in a 745

The US economy added 128,000 jobs in October. The unemployment rate rose slightly to 3.6%.The United States lost 36,000 manufacturing jobs last month, impacted primarily by the GM strike.Overall, the October report was stronger than expected, beating economists' far more dour forecasts. The 40-day GM strike, which took some 50,000 autoworkers out of the workforce, was 383

This story will be updated to reflect updated travel information. Air travel could be snarled heading into Thanksgiving thanks to a large snowstorm poised to sweep across the country on Tuesday and Wednesday. As a result, United and Delta have both announced waivers for some travelers impacted by this week's storm. The waivers allow travelers to rebook their flight without penalty. Adding insult to injury, a second storm could toil with travelers following the holiday. According to the National Weather Service, nearly a foot of snow is expected to fall in Denver, which is a major hub for United Airlines. The National Weather Service also cautioned drivers who will use Interstates 70, 26 and 76. United Airlines announced on Sunday travel waivers for those departing from Denver now through Nov. 29. The pre-Thanksgiving storm is then expected to travel north, where 5-7 inches of snow are expected around Minneapolis. Minneapolis is a major hub for Delta. Delta announced late Monday waivers for those flying out of Minneapolis.Although snow is expected to stay well to the north and west, Chicago, Indianapolis, Detroit and Cincinnati are expecting an extreme wind event. Much of the Midwest was placed under a high wind watch for Wednesday. Another storm is expected to sweep across the Rockies and Upper Midwest on Friday and Saturday, but it is too early to predict the amount of snow. 1411

Thousands of pro-gun rights activists converged around the Virginia Capitol on Monday to voice opposition to gun control legislation proposed by the Democratic-held legislature.Among the vocal critics of the bills were members of law enforcement, who used their official office to advocate against some of the proposals. The Grayson County Sheriff’s Office posted on its Facebook page its support for the protest. The sheriff’s office also posted photos of deputies in uniform holding a sign saying, “we support the second amendment.”“Great turnout for 2A rally in Richmond today! Standing room only!!” the post read. Culpeper County Sheriff Scott Jenkins also attended the rally to show his support. He said he would deputize gun owners if Virginia lawmakers move forward with gun legislation. It is unclear if said deputies would have arrest power.“My intent was to swear in thousands of auxiliary deputy sheriffs and make it legal for them to possess the weapons that they're trying to ban and restrict,” Jenkins said. Dozens of sheriffs in Virginia have stated that their departments would not enforce gun laws they feel are unconstitutional. Jenkins suggested, but would not directly answer, whether his department would enforce state laws involving gun control if Democrats move forward with legislation.“I'll have to make a determination if these laws they pass or a violation of that,” Jenkins said. Although thousands gathered in Richmond to protest gun legislation, Gov. Ralph Northam said there was a reason why Democrats were elected in Virginia. In his State of the Commonwealth address earlier this week, Northam referenced the legislature’s response to a mass shooting at a Virginia Beach municipal complex last year as a reason why Democrats gained a majority in the Virginia House for the first time in nearly three decades. “Virginians watched. They saw what happened, and they were appalled. So they changed the legislature. And here we are,” Northam said. While a bill to ban assault weapons was dropped earlier last week, other bills are still being considered. One is limiting the purchases of firearms to one a month.Earlier this month, Northam signed legislation to prohibit firearms inside of the Capitol building and an adjacent legislative office building. Another one of the more controversial bills is a so called “red flag” law, which would allow for law enforcement to take away firearms from gun owners who are considered a danger to themselves or others. Northam defended this legislation as “constitutional.” “If you have demonstrated extreme risk of violence, or there’s a protective order against you, you shouldn’t have a firearm. This means universal background checks. If there’s nothing in your record, you have nothing to worry about,” the governor said. Jenkins isn’t convinced. “Right now, it's hard to say that we're going to disarm our citizens who often have a 10- or 15-minute response time in rural areas for an officer to arrive and say we're going to disarm the homeowner and restrict their rights to defend themselves,” the sheriff said. Justin Boggs is a writer for the E.W. Scripps National Desk. 3162

The State Department evacuated 14 Americans suffering from COVID-19, better known as the coronavirus, from a cruise ship docked off the coast of Japan despite objections from the Centers for Disease Control and Prevention, 235