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吉林游离前列腺特异性抗原偏高
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发布时间: 2025-06-02 08:19:53北京青年报社官方账号
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  吉林游离前列腺特异性抗原偏高   

WASHINGTON, Aug. 4 (Xinhua) -- Researchers have found a way to turn mouse embryonic stem cells into sperm and this finding opens up new avenues for infertility research and treatment, according to a study published Thursday in the online edition of journal Cell,A Kyoto University team coaxed mouse embryonic stem cells into sperm precursors, called primordial germ cells (PGCs), and shown that these cells can give rise to healthy sperm. The researchers say that such in vitro reconstitution of germ cell development represents one of the most fundamental challenges in biology.When transplanted into mice that were unable to produce sperm normally, the stem cell derived PGCs produced normal-looking sperm, which were then used to successfully fertilize eggs. These fertilized eggs, when transplanted into a recipient mother, produced healthy offspring that grew into fertile male and female adult mice. The same procedure could produce fertile offspring from induced pluripotent stem cells that are often derived from adult skin cells."Continued investigations aimed at in vitro reconstitution of germ cell development, including the induction of female primordial germ cell-like cells and their descendants, will be crucial for a more comprehensive understanding of germ cell biology in general, as well as for the advancement of reproductive technology and medicine," the researchers wrote.

  吉林游离前列腺特异性抗原偏高   

BEIJING, July 15 (Xinhua) -- The Chinese Academy of Agricultural Sciences (CAAS) announced Friday that a group of international scientists has finished sequencing the genetic code of the potato.The Potato Genome Sequencing Consortium (PGSC), which is led by Chinese scientists and made up of 97 researchers from 14 countries, has sequenced the complete potato genome and published a report of its findings in the latest issue of the scientific journal Nature, said the CAAS.The research took six years and revealed that the potato contains about 39,000 genes, said the CAAS.Qu Dongyu, a potato farming specialist with the Crop Science Society of China and a promoter of the PGSC, said the study helped discover genes that define the growth and insect resistance of potatoes.The sequenced genome will enable scientists to create new varieties of potato that are high in yield and quality and more resistant to insects and diseases, he said.Huang Sanwen, a researcher with the CAAS and one of the three corresponding authors of the report, said the sequencing will also allow potato breeders to accelerate the breeding process of new seeds from 10 to 12 years to about 5 years.China is the world's top potato grower, with its farmers planting potatoes on nearly 90 million mu (6 million hectares) of land each year. The average yield per mu stands at 1,000 kg, only one-third of that harvested by countries with advanced technologies, Qu said.

  吉林游离前列腺特异性抗原偏高   

WASHINGTON, Aug. 2 (Xinhua) -- The weakness of aging is associated with leaky calcium channels inside muscle cells and a drug already in Phase II clinical trials for the treatment of heart failure might plug those leaks, according to a report published Tuesday in the online edition of Cell Metabolism.Earlier studies by the research team led by Andrew Marks of Columbia University showed the same leaks underlie the weakness and fatigue that come with heart failure and Duchenne muscular dystrophy."It's interesting, normal people essentially acquire a form of muscular dystrophy with age," Marks said. "The basis for muscle weakness is the same." Extreme exercise like that done by marathon runners also springs the same sort of leaks, he added, but in that case damaged muscles return to normal after a few days of rest. A microscopic view shows smooth muscle cells derived from human embryonic stem cells showing the nuclei (blue) and proteins of the cytoskeleton (green) in this handout photo released to Reuters by the California Institute for Regenerative Medicine, March 9, 2009The leaks occur in a calcium release channel called ryanodine receptor 1 (RyR1) that is required for muscles to contract. Under conditions of stress, those channels are chemically modified and lose a stabilizing subunit known as calstabin1.Calcium inside of muscle cells is usually kept contained. When it is allowed to leak out into the cell that calcium itself is toxic, turning on an enzyme that chews up muscle cells. Once the leak starts, it's a vicious cycle. The calcium leak raises levels of damaging reactive oxygen species, which oxidize RyR1 and worsen the leak.The researchers made their discovery by studying the skeletal muscles of young and old mice. They also showed that 6-month-old mice carrying a mutation that made their RyR1 channels leaky showed the same muscular defects and weakness characteristic of older mice.When older mice were treated with a drug known as S107, the calcium leak in their muscles slowed and the animals voluntarily showed about a 50 percent increase in the amount of time spent wheel running. Now in clinical trials for patients with heart failure, the drug is known to work by restoring the connection between costabilin and RyR1.Despite considerable effort to understand and reverse age- related muscle wasting, there are no established treatments available. The new work suggests there may be hope in approaching the problem from a different angle."Most research has focused on making more muscle mass," Marks said. "What's different here is that we are focused not on muscle mass but on muscle function. More muscle doesn't help if it is not functional."

  

  

ISLAMABAD, Sept.4 (Xinhua) -- Pakistan's eastern Punjab province is in the grip of a dengue epidemic with dozens of cases being reported daily at various hospitals across the province, said officials and hospital sources.A report issued by the provincial health department on Friday said that as many as 145 cases of dengue fever in Lahore, the provincial capital, and several other cities have been reported in Punjab over the past three days.The total dengue fever cases in the Punjab are 1,419 since the beginning of this year, out of which 1,358 Dengue patients had recovered and been discharged from hospitals, according to local media.Dengue, an acute febrile disease spread by the bite of the aedes aegypti has been endemic in Pakistan for the last few years. It spreads most often after the rainy season in July and August when pools of standing water serve as ideal mosquito breeding spots.Gravity of the dengue disease was felt at the central level and Prime Minister Yusuf Raza Gilani extended full support to the Punjab government in coping with the growing number of cases of dengue fever.The Prime Minister, who was in Lahore on Friday, directed his Principal Secretary to contact the Punjab government and assist them in taking necessary preventive measures against the Dengue fever. He also asked him to extend offer on behalf of the federal government for provision of any technical expertise to the Punjab government.Acting on reports that the virus was spreading rapidly and that measures to control it had been unsuccessful, Punjab Chief Minister Shahbaz Sharif has presided over series of meetings and ordered the immediate suspension of the Lahore district health officer for failing to control the epidemic.A task force comprising a government minister, health officials and doctors has been set up to review the situation and suggest measures to curb the virus.On the orders of the chief minister, giant advertisements on measures that can be taken to prevent dengue have appeared in the media.People have been advised not to allow water to stand in containers, to use mosquito repellents, spray homes and be particularly vigilant at dawn and twilight when the dengue- carrying mosquitoes bite.This increase in public vigilance and awareness may yet halt the spread of a disease that over the past few weeks has struck across the province, said specialists.Meanwhile, the Health Department spokesman also stressed awareness among the people for prevention, control and treatment of dengue virus. According to him, the symptoms of dengue fever include high fever, severe body pain, itching and red spots, bleeding from nose and teeth and severe pain in the eyes. He said precautions include proper covering of the pots having water, like buckets and drums, and using coils, mats and sprays for eliminating mosquitoes.He further said dengue mosquitoes usually attack early in the morning from 6 a.m. to 9 a.m. and from 4 p.m. to 10 p.m.in the evening. The patients should act upon the advice of qualified physicians only, he maintained.

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