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CLEVELAND — Scientists at the Cleveland Clinic Lerner Research Institute have successfully reversed Alzheimer's disease in mice.According to a news release, the researchers reversed the formation of harmful plaque in the mice's brains by gradually reducing an enzyme called BACE1, improving their mental function.“To our knowledge, this is the first observation of such a dramatic reversal of amyloid deposition in any study of Alzheimer’s disease mouse models,” says Riqiang Yan, one of the scientists on the team. The study raises hopes that drugs aimed at this same enzyme will soon be able to treat Alzheimer's disease in humans. You can read the full study in the Journal of Experimental Medicine here. 735

Climate studies often pinpoint the detrimental public health impacts related to rising atmospheric temperatures, extreme weather events and other consequences of a changing climate.A report released by the World Health Organization on Wednesday details the public health benefits that could come with tackling the issue.Meeting the commitments of the 2015 Paris climate agreement could save millions of lives and hundreds of billions of dollars by the middle of the century, according to the report.Meeting the goals put forth in the Paris agreement would be expected to save more than 1 million lives a year from air pollution alone by 2050, it says. Drivers of climate change, principally fossil fuel combustion, contribute to about 7 million deaths worldwide from outdoor and indoor air pollution annually, according to the report.The Paris Agreement is a pledge among representatives from countries around the world to take action against climate change, specifically by reducing their nations' carbon output and halting global warming below 2 degrees Celsius over pre-industrial levels by the end of the century. The United States pledged to withdraw from the landmark agreement last year.Global leaders and officials are now gathering for two weeks of meetings at the 24th Conference of the Parties to the United Nations Framework Convention on Climate Change, or COP24, to create a rulebook that will turn the Paris climate agreement into a workable reality. They aim to establish rules, figure out financing and build ways to verify that nations are meeting their commitments.UN Secretary-General Antonio Guterres called for action Monday in Poland, telling gathered delegates that "we are in deep trouble with climate change." 1743

COLORADO SPRINGS, Colo. — The back and forth between President Donald Trump and North Korea's president Kim Jung Un is constant. But what if North Korea acted on its threat of sending a nuclear missile to American shores? An Air Force base in Colorado Springs would play a critical role in the event of such an attack.If the unthinkable happens, soldiers in a secure room on Schriever Air Force Base in Colorado Springs will fight back. From a fortified facility, they have the power to launch what's known as a kill vehicle. Propelled into space by a rocket, the kill vehicle can destroy a warhead above the earth.The mission would be administered by members of the 100th Missile Defense Brigade."The threat we're dealing with is very real," said Colonel Kevin Kick, who is the commander of the 300-person team. "We say we are the 300 defending the 300 million."From their hub in Colorado, the interceptors can be launched from bases in Alaska and California, obliterating a nuclear warhead in a matter of minutes.The U.S. military allowed Denver7 television station, owned by the E.W. Scripps Company, to capture an exercise of a simulated attack on Los Angeles. Security is so sensitive, we can't tell you the participant's names.Soldiers say they train constantly so they are prepared in the event of an attack. “We train continuously — every shift, multiple times," said one unnamed solider.During our visit, the computer monitors were blacked out and had post-it notes covering the information— part of the efforts to prevent a breach."It's a very humbling experience to know that we are responsible for the defense of the homeland for the entire United States," said Lt. Alberto Squatrito .These soldiers are the best of the best— a blend of active military and National Guard, who work side-by-side after passing some of the toughest tests in the military."Unlike most school houses in our Army, you have to have an ‘A’ average just to pass the course," said Kick.And that makes sense, considering they're at the controls that can determine life and death or prevent a nuclear annihilation."Do you ever get a lump in your throat, knowing the seriousness and importance of what you do here?" asked Denver7’s Marc Stewart."Yes, I do get a sense of pride. I do get a lump in my throat. We're here to keep America safe," said the soldier.But not everyone is convinced this system will work. Some Pentagon testing has shown failures, with only about half of the tests being successful.Yet the technology is constantly being upgraded and revised. The soldiers tell Denver7 they stand behind it, saying they sleep at night feeling safe. 2675

College students rely on internships to give them hands-on experience before graduating and going into the workforce. However, this year, 22% or nearly one in four college students had their summer internships canceled because of the pandemic, according to a survey done by the National Association of Colleges and Employers.“I was supposed to work with the Indianapolis Motor Speedway this summer, working full-time for about 10 weeks,” said Purdue University junior Patrick Haimbaugh. “I was really excited about it, but it did get canceled.”Fortunately for Haimbaugh, when his internship fell through, a company called TechPoint was seeing how many students were losing internships and decided it wanted to help.“It felt like I had a second chance, like the summer wasn’t just going to be a blowout,” said Haimbaugh.“We thought you know what based on our organization, position and where we sit in the community, this is an area where we can make a difference,” said Mike Langellier, the CEO of TechPoint.TechPoint normally has a summer internship program that helps about 100 students, but in the wake of the wave of internship cancellations, it decided to create a second summer internship program for five times as many students. The new program was practically created overnight and called the SOS Challenge.“Their task is over the course of five weeks to come up with a product prototype and a go-to market strategy aimed at one of nine different challenge topics, and they are all COVID related,” said Langellier. “So, they include things like tele-health, outbreak detections, restaurants and small businesses.”TechPoint got 56 other companies and more than 250 tech professionals to commit to helping with the SOS Challenge interns. Beyond the networking and mentorships, TechPoint setup the internship to have ,000 prize for the group with the best prototype and arranged for the group to get an award from Indiana’s governor.“We are excited to be able to make a difference amidst challenging times for so many people,” said Langellier.With unemployment rates so high, college graduates are entering one of the most competitive jobs markets ever. So, any extra experience now is probably more helpful than ever.“I am so thankful for the team at TechPoint,” said Haimbaugh. “For people who lost their internship, I say keep looking because there are opportunities. They are hard and it is going to be hard to get them but keep trying.” 2457

Complaints are growing nationwide about workplace safety issues related to coronavirus. The Occupational Safety and Health Administration, or OSHA, has received more than 6,500 nationwide on a federal level since February.One trial lawyer who works in employment law says she expects the number of complains will keep going up.“Where I really think the numbers are going to escalate is in the retaliation world, where employees bring issues to their employers' attention about failing to implement appropriate administrative or engineering controls or social distancing measures and then they feel that they have suffered an adverse employment action as a result of bringing this to their employer's attention,” said trial lawyer Laura Lawless.OSHA recently updated its guidance on COVID-19-related workplace safety. It now suggests wherever possible and feasible employers should require masks at work.This guidance is something Lawless says everyone was waiting on. She says for states or cities that already had a mask mandate it was easier to enforce at work already, but for states that don't have this mandate, it was harder until now.“At least you can now turn to CDC guidance and OSHA guidance as an employer and say look even if you disagree with us for a political reason or personal expression reason, we're following the guidance from agencies that are meant to look out for your health and safety,” said Lawless.Still, there are concerns OSHA isn't going far enough in other areas. One big criticism among employee protective organizations, workers organizations and unions is that OSHA’s guidance on COVID-19 isn't a regulation and doesn't really have any teeth.Virginia and Oregon are two states looking to fill in the gap with their own worker protections.If you see issues in your workplace, the employment lawyer recommends being reasonable in your approach and not getting too emotional in your reaction. She says also keep careful documentation about who you spoke to and what you talked about. 2022