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The first participant in a clinical trial for a vaccine to protect against the new coronavirus will receive an experimental dose on Monday, according to a government official.The National Institutes of Health is funding the trial, which is taking place at the Kaiser Permanente Washington Health Research Institute in Seattle. The official who disclosed plans for the first participant spoke on condition of anonymity because the move has not been publicly announced.Public health officials say it will take a year to 18 months to fully validate any potential vaccine. Testing will begin with 45 young, healthy volunteers with different doses of shots co-developed by NIH and Moderna Inc. There’s no chance participants could get infected from the shots, because they don’t contain the virus itself. The goal is purely to check that the vaccines show no worrisome side effects, setting the stage for larger tests.Dozens of research groups around the world are racing to create a vaccine as COVID-19 cases continue to grow. Importantly, they’re pursuing different types of vaccines — shots developed from new technologies that not only are faster to produce than traditional inoculations but might prove more potent. Some researchers even aim for temporary vaccines, such as shots that might guard people’s health a month or two at a time while longer-lasting protection is developed.Also in the works: Inovio Pharmaceuticals aims to begin safety tests of its vaccine candidate next month in a few dozen volunteers at the University of Pennsylvania and a testing center in Kansas City, Missouri, followed by a similar study in China and South Korea.Even if initial safety tests go well, “you’re talking about a year to a year and a half” before any vaccine could be ready for widespread use, according to Dr. Anthony Fauci, director of NIH’s National Institute of Allergy and Infectious Diseases.That still would be a record-setting pace. But manufacturers know the wait — required because it takes additional studies of thousands of people to tell if a vaccine truly protects and does no harm — is hard for a frightened public.President Donald Trump has been pushing for swift action on a vaccine, saying in recent days that the work is “moving along very quickly” and he hopes to see a vaccine “relatively soon.”Today, there are no proven treatments. In China, scientists have been testing a combination of HIV drugs against the new coronavirus, as well as an experimental drug named remdesivir that was in development to fight Ebola. In the U.S., the University of Nebraska Medical Center also began testing remdesivir in some Americans who were found to have COVID-19 after being evacuated from a cruise ship in Japan.For most people, the new coronavirus causes only mild or moderate symptoms, such as fever and cough. For some, especially older adults and people with existing health problems, it can cause more severe illness, including pneumonia. The worldwide outbreak has sickened more than 156,000 people and left more than 5,800 dead. The death toll in the United States is more than 50, while infections neared 3,000 across 49 states and the District of Columbia. The vast majority of people recover. According to the World Health Organization, people with mild illness recover in about two weeks, while those with more severe illness may take three weeks to six weeks to recover.___The Associated Press receives support for health and science coverage from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 3597

Terry Jones, a member of the Monty Python comedy troupe, has died at 77. Jones's agent says he died Tuesday evening. In a statement, his family said he died “after a long, extremely brave but always good humored battle with a rare form of dementia, FTD.” With Eric Idle, John Cleese, Michael Palin, Graham Chapman and Terry Gilliam, Jones formed Monty Python's Flying Circus, whose anarchic humor helped revolutionize British comedy. 445

The American Society for the Prevention of Cruelty to Animals provided tips on Tuesday on how to keep animals safe and healthy as the country deals with the spread of coronavirus. Here are the tips provided by ASPCA: Wash Your HandsAlthough there is no current evidence that suggests the coronavirus can be transmitted to or from companion animals, it's always a good idea to follow basic hygiene practices around animals. This includes washing your hands thoroughly throughout the day and before and after direct contact with your pets, their food or their supplies.Play it SafeWhile there have not been any reports of companion animals becoming sick from the virus, it is still recommended that people who are sick with COVID-19 limit contact with companion animals until more information is available. If you are sick or under medical attention for COVID-19, you should avoid close contact with your pets and have another member of your household care for your animals. If you must look after your pet, you should maintain good hygiene practices and wear a face mask, if possible.Stock Up on Pet SuppliesPrepare a kit with essential supplies to have on hand in the event of an emergency. Your emergency kit should include a 30-day supply of your pets' medications, as well as at least two weeks' worth of food and other supplies, like litter. Make sure all pets wear collars and tags with up-to-date identification information. Your pet's ID tag should contain his name, telephone number and any urgent medical needs. Be sure to also write your pet's name, your name and contact information on your pet's carrier.Designate an Emergency CaregiverProactively identify someone who could help with their short- or long-term care in the event you are unable to care for your pets. Consider a family member, friend, neighbor or a boarding facility.Create a Pet DossierIf your emergency caregiver's assistance is needed, make it easier for them by having all of your pets' information in one place. Consider including things like habits, food preferences, medical conditions and medications taken, veterinarian contact information, medical and vaccination records, and any behavioral tendencies. 2203

The NHL and the NHL Player Association reached an agreement Friday night to move forward on a plan to resume the season, starting with a 24-team playoff. The season was suspended on March 12, as most teams had completed roughly 70 games of an 82-game schedule. The regular season was set to conclude in April, with the 16-team Stanley Cup Playoffs extending into early June. The resumption plan calls for 24 teams to participate in a playoff, while the bottom seven clubs would effectively have their seasons finished."The Executive Board of the National Hockey League Players’ Association (NHLPA) has authorized further negotiations with the NHL on a 24-team return to play format to determine the winner of the 2020 Stanley Cup,” the NHLPA said in a statement. “Several details remain to be negotiated and an agreement on the format would still be subject to the parties reaching agreement on all issues relevant to resuming play."Earlier this week, NHL Commissioner Gary Bettman said that the season could resume with games being played in centralized locations. This would eliminate the need for travel and additional exposure to the coronavirus among players and team personnel. Bettman said that access to tests will remain a key issue in resuming the NHL season. 1282

The Dow Jones Industrial Average closed down more than 800 points on Tuesday — a day after the Dow dropped more than 1,000 points in the biggest single-day loss of 2020.The Dow finished Tuesday down 878 points, marking the fourth-largest one-day drop in the market's history. Fears about the worldwide spread of COVID-19, better known as coronavirus, have prompted a slowdown in global markets. The CDC compounded fears of the spread of the disease Tuesday when it said that Americans need to prepare for "significant disruptions" to their daily lives."Ultimately we expect we will see community spread in this country," CDC Director of Immunization and Respiratory Diseases Dr. Nancy Messonier. said. "It’s not so much a question of if this will happen anymore, but rather more a question of exactly when this will happen and how many people in this country will have severe illness."The two-day drop has wiped out all year-to-date gains the Dow has made since the new year began.The loss also comes hours after President Donald Trump attempted to assuage fears of a global economic slowdown. Speaking at a press conference in India, Trump claimed that his administration would prevent the spread of the virus. "I think it's going to be under control and it's going to work out fine," Trump said. 1309