吉林最有名的男性医院(吉林做包皮包茎去什么医院好) (今日更新中)

Justin Bieber says that he has been battling Lyme disease. In an Instagram post on Wednesday, the pop star wrote that it's been a rough couple of years but he's been getting the right treatment. Bieber's post promised that he'll “be back and better than ever.” Lyme disease is transmitted by Ixodes ticks, also known as deer ticks. Lyme can cause flu-like conditions, neurological problems, joint paint and other symptoms, but is curable in most cases. Bieber says he will discuss battling the tick-borne infection on his upcoming YouTube docu-series, “Justin Bieber: Seasons,” which debuts on Jan. 27. 615

In an already-crowded primary field, former Pennsylvania Rep. Joe Sestak became the latest Democratic candidate to wade into the race for the presidency, announcing his candidacy in a video posted to his website Sunday morning.Sestak, who mounted 259

It’s hard to regard Ellie as a menace.When Greg Manteufel is frustrated or feeling down, she sits by him. At night, she sleeps under his covers. At dinner, she’s there next to him, knowing he’ll throw something her way. She belies the stereotype of the vicious pit bull.“We love her like she’s our daughter,” he said of the dog.And yet, Ellie may be the reason Manteufel nearly died.Gravely ill, he lost parts of his arms and legs, as well as the skin of his nose and part of his upper lip. The cause was capnocytophaga (cap-noh-seye-TOE’-fah-gah), a germ from Ellie’s mouth or from another dog he encountered.Capnocytophaga is commonly found in the saliva of cats and dogs and almost never leads to people getting sick, unless the person has a compromised immune system. But Manteufel was perfectly healthy. In fact, he doesn’t think he’d ever used his health insurance before he fell ill.The case is extremely rare and doctors at his hospital, Froedtert & the Medical College of Wisconsin, had no explanation for why he got so sick. But over the last 10 years there have been at least five other healthy people who have had severe reactions to the germ. A team of researchers connected with Harvard Medical School has developed a theory on why — a gene change in all the victims.And their finding means doctors can’t rule out the capnocytophaga bacteria could strike Manteufel and other victims again.___Greg Manteufel thought he was getting the flu in June of 2018. He had a fever, vomiting and diarrhea. But when he started getting confused, his family took him to the hospital.Doctors did blood cultures and found capnocytophaga, which caused sepsis, a severe blood infection that led to his blood pressure dropping and many of his organs shutting down.“Do what you have to,” he told the doctors.He had so much to live for — foremost, his wife of 16 years, Dawn, and 26-year-old son, Mike. He was just starting to get really good at his day job, painting houses. He cherished his Harley Davidson Electric Glide. He was in the middle of fixing up his ’66 El Camino. And of course there was Ellie, the pup.And so he persisted, through more than 20 surgeries, including amputations of his left and right arms just below the elbow, and legs through the middle of the knee.His wife and son stayed optimistic, because he was.“Greg said he didn’t come this far to lay down and let this beat him,” Dawn Manteufel said.He was out of the in-patient rehab unit in about two weeks, learning to move from his wheelchair to the bed, toilet and car. The usual stay is three to four weeks, said Dr. David Del Toro, medical director for the inpatient rehab unit at Froedtert.Manteufel made similar quick advances using his arm prosthetics and leg prosthetics.“He does not seem like any other patient I’ve met before,” Del Toro said. “He’s just, you know, full speed ahead.”Meanwhile, researchers at Brigham and Women’s Hospital in Boston, connected to Harvard Medical School, as well as Dana-Farber Cancer Institute and Beth Israel Deaconess Medical Center had been investigating cases like his.The team has done genetic testing on five otherwise healthy people who suffered capnocytophaga infections to see if they could find anything in common. They discovered all had a gene connected to the immune system that was working differently — a genetic variant.“It was a really thrilling moment,” said Elizabeth Fieg, a genetic counselor at Brigham and Women’s Hospital. “The stakes are so high with these cases and the patients have gone through so much.”They believe it makes those people more susceptible to developing severe medical problems from capnocytophaga. But they are also trying to determine if there are other risk factors.Of the five in the study, three survived with amputations and two did not. Fieg hopes their research can determine why some did not survive.She also hopes if their theory is confirmed, it will help diagnose cases faster, and perhaps save lives and limbs.That’s why Greg Manteufel jumped at the chance to take part when he was approached in August.Researchers need to gather more evidence, but hope to publish their study in the next year to 18 months.___Manteufel’s life now includes frequent occupational therapy appointments to perfect his use of arm prosthetics — the kind with metal moveable hooks at the end. He’s using a fork regularly and he’s now working on picking up the TV remote, opening doorknobs, cutting vegetables and doing the dishes.He’s using shortened leg prosthetics, called stubbies, to get his body conditioned to eventually use to full-sized ones. Those are expected to arrive any day.Plastic surgeons plan another surgery to perfect his nose. They’ve already moved skin from his forehead there. It looks oversized now, but it will eventually fit in with the rest of his face.He plans to get his car revamped so he can drive with prosthetics. He wants to get a special pole so he can go fishing again. He is even considering going back to work painting.He’s also become less quiet and a lot more outgoing. “Now everybody I see wants to hear something or talk to me. I tell them a 15-minute story about what happened. They probably want me to leave, you know,” he said, chuckling.Ellie’s often by his side.“She loves kids. She loves puppies. Other dogs,” Manteufel said.As harmless as she seems, she may have capnocytophaga germ.The results of Manteufel’s genetic tests are expected in three to four months. Fieg said people with the gene variant are at increased risk for recurrent capnocytophaga or other infections in the future.While Manteufel doesn’t like the sound of that, he said Ellie’s accidentally scratched him since he’s been home and even licked his mouth. He’s been fine.And even if he does have the gene variant, he said, it changes nothing.“We didn’t even bother testing her,” said Manteufel. “We weren’t going to get rid of her if it was her that caused it anyway.”“We just love her to death.” 5972

It started out as a limp.At the time, father Shawn Cress thought daughter Chloe, then 12 years old, just needed some physical therapy. That was June 2018.But the limp turned into a fever, which led to lab tests at the doctor's office that "didn't look good," Shawn recalls. And by then, Chloe was having back pain.All this for the Kingsport, Tennessee family turned into a referral to Niswonger Children's Hospital in Johnson City, about 34 miles away, where doctors gave Chloe a CT scan. That's how they found the mass -- a giant tumor near Chloe's heart that had spread down to her esophagus and into some of her vertebrae, causing the back pain.It was 667

KANSAS CITY — Maureen Boesen has always known cancer risk was high in her family."We're able to really track our history of breast cancer back to the late 1800s and early 1900s," Boesen said. "My grandmother actually passed away from ovarian cancer when she was 44. She had five sisters and none of them lived to the age of 50. Then, my mother was diagnosed with breast cancer when she was 32. We knew there was something going on and that it was a very young age."When Boesen and her two sisters were ages 3, 5 and 7, their mom was already receiving chemotherapy for stage 2 breast cancer. Because of the extensive family history, the girls were part of a study at a university in another part of the Midwest. Their mom was hoping to help the world better understand what was killing so many women. She was hoping to better her daughters' chances for survival."We were all tested in the same exact room," said Boesen's sister, Bridget Stillwell. "I can even remember what the room looked like." Because the girls were so young, and the health threat still likely years away, they wouldn't receive their DNA test results until they turned 18."We knew we were part of a study," Boesen said. "We knew our results were waiting for us, but we didn't know what they were."When asked if she found that wait frustrating, she said emphatically it was not."Quite the opposite. We felt empowered," she said.She didn't get the results right away. The sisters knew there was nothing they could likely do at age 18 even if their test results showed they'd inherited the BRCA gene mutation. The sisters all waited until they were around age 21. One sister was positive. One sister was negative. Boesen remembers meeting with the researcher to learn her results."We sat down and we had a conversation about what BRCA was and what it meant for my family," Boesen said. "It was a lengthy conversation, which made me very uncomfortable because why would a conversation that wasn't going to change my life last that long?"Eventually, the researcher told her she had inherited the gene mutation."It was just devastating because I knew what breast cancer and ovarian cancer can do to a family. You know, my first question out of my mouth was, 'Is there any chance this could be wrong?' The researcher said 'No.' "Boesen walked out of that meeting determined. She was going to make decisions to save her own life. She was going to have a bilateral prophylactic mastectomy. She would schedule a surgery to remove both breasts to prevent breast cancer."This was me doing what I was supposed to do and this was me being empowered and me being proactive and not waiting until I have a cancer diagnosis," Boesen said.She didn't want to feel like a ticking time bomb. She wanted to live.Boesen had the surgery to remove both breasts when she was just 23 years old. She went on to get married and have three children."I didn't get to breastfeed them. It was sad. I'm not brokenhearted or devastated about it, but it is sad to think I couldn't provide for my children like that," she said.At the time, she still believed she'd made the right decision because she was healthy.Once done having children, she knew there was another step that most people with the dangerous BRCA gene mutation have to consider."I knew that when I was done having children, I needed to have a complete hysterectomy," Boesen said.The BRCA gene mutation not only dramatically increases a woman's chance of developing breast cancer at a young age, it also significantly increases a woman's chance of ovarian cancer."The right thing to do and what the doctors say to do is have a complete hysterectomy by the age of 35 and I was in my early 30s," Boesen said.In 2018, she went to a hospital in Kansas City, Missouri, to start the process of preparing for her hysterectomy. Both her health care provider and her insurance company wanted a new DNA test. Everyone knew what the results would be, but they went through the motions to get the required confirmation she was positive for the deadly gene mutation which was so rampant in her family.The test results were supposed to be back in a few weeks, but it had been four and Boesen was starting to worry. Then, she got the call from the doctor."I was at work. And the first thing she said was, 'We need to talk', and my heart just sank," Boesen said. "She said, 'You're negative,' and I just started bawling."She was overwhelmed, confused and full of emotions."I was angry. I was regretful. I was happy. I was sad. I so desperately wanted to feel relief, 'Oh, thank God, this is the best day of my life,' but it wasn't," Boesen said. "It was just devastating."Boesen got another test to confirm the second test results. It also came back negative.She did not get the hysterectomy. There was no need now. There was no longer a threat that cancer was waiting to explode in her body. She now knew she had not inherited the BRCA gene mutation that had killed so many of her relatives.Dr. Jennifer Klemp of the University of Kansas Cancer Center has worked in the field of cancer genetics, specifically breast and female cancers, since 1997. She is the director of Cancer Survivorship and a cancer risk counselor. While she was not involved in Boesen's original research, she says she's not surprised."Twenty years ago, when we sent our first tests and BRCA 1 and 2 were the two genes we tested for, about 30-40 percent of the time we would get something called a 'variant of uncertain significance,' " Klemp said. "Basically, that meant we found a mutation or an error in the DNA, but we didn't know if that was associated with an increased risk of cancer. Today, using a reputable lab, that should be less than 1-2 percent."Klemp says things are changing rapidly in the field of genetic testing. If someone had a DNA test more than five years ago, they should consider having an updated test. She also says the at-home tests are good for finding out details about your ancestry, but they shouldn't be used to make major decisions about your health. For that, you'd want a health professional to order a commercial test through a certified, reputable lab. With more and more companies offering testing, and more medical professionals and patients interested in genetic testing for so many reasons, she says demand right now is outpacing supply."If you have 10 different labs doing testing, and you have every primary care, OB-GYN, oncology clinic, surgical clinic and any number of patients eligible for testing, it's a little bit of the wild west," Klemp said, adding there's no central repository for this patient and test information.As for Boesen, the university where the original research was done and the false positive originated offered to re-test her DNA. She is currently waiting on the results from what is now her fourth genetic test. She hopes it comes back negative, too, which is what the experts all expect. She believes, then, finally, she'll be able to move forward with her life. Boesen and her two sisters are writing a book about their experiences. Each of her sisters has a story to tell, too. Their book will be titled, " 7146

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