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SAN DIEGO (KGTV) — It has now been seven months since the pandemic began, and there are still a lot of questions about the best ways to treat patients with COVID-19.Researchers at UC San Diego are leading an effort to produce swift and reliable answers that could help doctors tailor treatments and hospitals plan bed space more efficiently.Doctors agree: the best way to fight any disease is to tailor the treatment for each individual based on their age, gender, race and other factors. But how does one doctor do that with a new disease like COVID-19, especially if their hospital has only seen a few hundred cases?“There might be some patterns you can get from 500 patients but there might be some others that you cannot,” said UCSD professor Dr. Lucila Ohno-Machado, chair of the Department of Biomedical Informatics.Dr. Ohno-Machado’s solution? Pool data.She’s leading the charge behind COVID19questions.org, a collaboration between 12 medical systems spanning more than 200 hospitals across the country.The collaboration includes several University of California health systems, the University of Texas Health Science Center at Houston, the University of Colorado Anschutz Medical Campus, and the largest organization in the cohort, the Veterans Affairs Healthcare System.“Each hospital is a little small to answer the questions. So by having it all together, we get the answers quicker,” said Ohno-Machado.They’re going after answers on how long patients with diabetes or cancer stay in the hospital, and whether COVID-19 is deadlier for smokers or non-smokers.Their findings revealed that men are much more likely to wind up on a ventilator than women.And they quantified just how much better we’ve gotten at treating COVID-19 over time.Since May 1, hospital stays among surviving patients have shrunk more than 10 days on average. That’s important for hospital managers planning and predicting bed space.“We decided to open this to the public and to our colleagues, and then we pick which answers have not been answered before and seem to be of most general interest,” Dr. Ohno-Machado explained.If this sounds like a straightforward approach, it’s not. Patient confidentiality laws make it hard for hospitals to share data and the information released by the CDC is limited.Maintaining patient confidentiality while sharing granular data is the most groundbreaking feature of the collaboration, called Reliable Response Data Discovery or known by its Star Wars-inspired acronym, R2D2.UCSD said R2D2 differs from other patient databases and registries because each health system maintains control of data rather than sharing it in a central repository. Through advanced computer techniques, each partner agency shares aggregated data, not patient-level information.The collaboration’s research is based on what’s called “observational data,” so Dr. Ohno-Machado said it’s not a replacement for a randomized, controlled clinical trial, which takes time. She noted their data reflects lessons on hospitalized patients, not everyone infected with the virus.But she said at a time when fast answers can save lives, COVID19questions.org could help. 3161

SAN DIEGO (KGTV) -- Lifeguards Thursday rescued a 17-year-old girl who fell while hiking at Blacks Beach near Torrey Pines.Lifeguards say the teen was hiking with two other teenagers near Box Canyon about 1:30 p.m. when she fell at least 12 feet into a creek bed.A San Diego Fire-Rescue helicopter flew her to safety. Lifeguards helped the girl's companions walk down to the beach.The girl injured her leg and possibly her head. She was taken to Scripps Hospital in La Jolla.Lifeguards said three other people were rescued about the same time, including one person who started climbing down the cliff and became too scared to go up or down.Watch video from the scene in the player below:  711

SAN DIEGO (KGTV) — It’s one of the few drugs shown to help fight the novel coronavirus, and a large federal study on remdesivir just entered a new phase.Previous research sponsored by the National Institute for Allergy and Infectious Disease showed remdesivir shortened recovery time in hospitalized COVID-19 patients on average from 15 days to 11 days.Now scientists and doctors are racing to find the perfect cocktail against COVD-19 by blending remdesivir with other drugs.California-based Gilead Sciences originally developed the drug to fight Ebola, but remdesivir was never approved. Gilead Sciences has offices in Oceanside.The drug works by interrupting the virus’ ability to replicate.“Remdesivir acts by shutting down virus production,” said Dr. Peter Chin-Hong, an infectious disease expert at University of California San Francisco. “It just forces the virus to stop making virus children.”Dr. Chin-Hong is studying remdesivir as part of the NIAID research.The problem is that stopping the virus from replicating isn’t enough for some severely ill patients. They suffer from a second problem: massive inflammation from the immune system’s war with the virus.That’s why scientists are trying a cocktail approach.“You have the virus to take care of, but you also have the body's response to the virus, which is inflammation, that you also have to take care of,” said Dr. Chin-Hong.Researchers started testing the first drug cocktail in May, using an arthritis drug called baricitinib that tames inflammation.But as the data on that part of the study gets crunched, researchers began testing the second cocktail this month, a combination of remdesivir and interferon beta.“Interferon beta is something we produce naturally to fight viruses,” said Dr. Chin-Hong. He said studies have shown people who don’t produce enough interferon beta struggle to fight off the virus.Researchers selected interferon beta after two small studies showed promising results against the coronavirus.Interferon beta can both reduce inflammation and kill viruses, so doctors are hoping it will be a potent one-two punch with remdesivir.Dr. Chin-Hong said he and other researchers started administering the new cocktail this month.Some patients will receive the cocktail, some will receive a placebo, and some will get remdesivir only. This kind of clinical trial is called an adaptive trial, which the FDA started encouraging in 2004. After each phase, the winning drug or cocktail will be tested against a new challenger.Dr. Chin-Hong said the eventual cocktail may include three or more drugs, similar to HIV medication. 2617

SAN DIEGO (KGTV) - It’s the largest loss of life in United States Navy history and you can read an award-winning account of it by two San Diego authors. ‘Indianapolis: The True Story of the Worst Sea Disaster in U.S. Naval History and the Fifty-Year Fight to Exonerate an Innocent Man’ is being released as a paperback after the hardcover became a New York Times bestseller. Sara Vladic and Lynn Vincent wrote the book together after researching it for more than 17 years. “It’s so much more than a sinking story and a shark story,” said author Lynn Vincent. Vladic spent nearly two decades interviewing survivors from the sinking USS Indianapolis. “Getting to know these men and their story and heroism and what it took to survive those days is incredible,” added Vladic, “it still teaches us lessons today of what the cost of freedom really is and what we should be remembering.” The book is cinematically written and presents multiple accounts from the men that had to fend off sharks and each other for several days at sea after the heavy cruiser was sank by the Japanese during WWII. The authors say they are in talks with several streaming services to make a miniseries based on the book. 1202

SAN DIEGO (KGTV) -- Margaret Hunter, the wife of Rep. Duncan Hunter, changed her plea to guilty to one count of conspiracy in a plea deal with the federal government over misused campaign funds Thursday.As part of a plea deal with prosecutors, Margaret Hunter will testify against her husband in his upcoming trial in September. The congressman and his wife both pleaded not guilty in 2018 to federal charges of using 0,000 in campaign funds for personal use and falsifying campaign finance reports. "Defendant agrees to plead guilty to Count One of the Indictment charging her with conspiring with co-defendant Duncan D. Hunter to knowingly and willfully convert Duncan D. Hunter for Congress Campaign Committee funds to personal use by using them to fulfill personal commitments, obligations and expenses would have existed irrespective of Hunter's election campaign and duties as a federal officeholder, in amounts of ,000 and more in a calendar year," the plea deal states.Those expenses include a ,000 family vacation to Italy and a 0 Easter brunch at the Hotel del Coronado.READ THE PLEA AGREEMENT HEREThrough her attorney, Margaret Hunter apologized for her actions through her attorney outside Federal Court on Thursday."I understand that there will be more consequences stemming from my actions, but as demonstrated this morning with the entry of the plea, I have taken the first step in facing those consequences," said Tom McNamara, her attorney, in a prepared statement.According to an affidavit, Hunter allegedly spent the money on expenses like vacations, dental work, tuition, movie tickets, video games and home utilities, among other things.The affidavit goes on to allege that the Hunters lied about the purchases in FEC filings, claiming the money was used for things like dinner with volunteers or campaign contributors, toy drives and teacher/parent events.Rep. Duncan Hunter issued a statement which reads:"I do not have the full details of Margaret’s case, but it's obvious that the Department of Justice (DOJ) went after her to get to me for political reasons. As Margaret’s case concludes, she should be left alone. I am the Congressman, this is my campaign and any further attention on this issue should be directed solely to me. The DOJ’s prosecutorial actions in this case were led by local U.S. Attorneys who attended Hillary Clinton fundraisers in violation of the Hatch Act. The fact remains that this entire matter should have been handled by the Federal Elections Commission (FEC). The DOJ purposely choosing to involve itself in the area where the FEC has primary jurisdiction reveals that their primary agenda was to inflict as much political damage as possible in hopes of picking up a congressional seat. It was politically-motivated at the beginning, it remains politically-motivated now."A trial date was set for September 10, 2019, but that is expected to change following this morning’s court appearance. A conviction would not force Hunter out of office. It takes a two-thirds house vote to do that, meaning 55 Republicans would have to move the same. San Diego Political Analyst John Dadian said he believes Hunter would be expelled if convicted. He added President Trump could pardon him, but it would likely be after the 2020 election. Meanwhile, he said East County Republicans are preparing to file to run if they see an opening. Margaret Hunter is set to be sentenced Sept. 16.DUNCAN HUNTER INDICTED:10News Exclusive: Hunter addresses indictmentCongressman Duncan Hunter and wife indicted for campaign fund misuseREAD: Federal charges against HuntersAffidavit alleges Rep. Duncan Hunter spent campaign funds on vacations, tequila shotsPHOTOS: Alleged instances of campaign fund misuse in Hunter affidavitReport: Rep. Duncan Hunter womanized, boozed and misused funds 3834