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WASHINGTON, June 8 (Xinhua) -- Hundreds of small genetic variations are associated with autism spectrum disorders, including an area of DNA that may be a key to understanding why humans are social animals, according to a multi-site collaborative study led by researchers at Yale University.To be published Thursday in the journal Neuron, the study reinforces the theory that autism, a disorder that develops in early childhood involving impairments in social interaction, language deficits and distinctive behaviors, is not caused by one or two major genetic defects, but by many small variations, each associated with a small percentage of cases.The study looked at more than 1,000 families in which there was a single child with an autism spectrum disorder, an unaffected sibling and unaffected parents. The team compared individuals with autism to their siblings to determine what types of genetic changes distinguished the affected child from the unaffected child.One of the most intriguing of these findings points to the same small section of the genome that causes Williams syndrome -- a developmental disorder marked by high sociability and an unusual aptitude for music.In autism, there is an increase in the chromosomal material, an extra copy of this region, and in Williams syndrome, there's a loss of that same material," said lead author Matthew State. "What makes this observation particularly interesting is that Williams syndrome is known for a personality type that is highly empathetic, social, and sensitive to the emotional state of others. Individuals with autism often have difficulties in the opposite direction. This suggests that there is an important key in that region to understanding the nature of the social brain."State and his team also found about 30 other regions in the genome that are very likely contributing to autism and are focused on about six of those regions that showed the strongest evidence."We're now moving on to a second phase of the study looking at an additional 1,600 families and should be able to identify multiple new regions that are strongly implicated in autism," he said.
GENEVA, Aug. 12 (Xinhua) -- 18 people seeking treatment at hospitals in Somalia had been confirmed cholera positive through laboratory tests, the Geneva based World Health Organization (WHO) said on Friday.The 18 positive cases were detected out of 30 stool samples collected from patients seeking treatment at hospitals for acute watery diarrhea, a symptom that could result from cholera, WHO spokesperson Tarek Jasarevic told reporters.All confirmed cases, including residents of Mogadishu district and those among internally displaced persons (IDPs), were said to be tested positive for the Vibrio cholera serotype "inaba", which had been the predominant serotype in Somalia for the past three years."These results are an alarming reminder of the critical situation in Mogadishu and other parts of Southern, Central Somalia, (which are) still experiencing drought, population displacement and conflict," Jasarevic said.WHO has reported a dramatic increase of acute watery diarrhea cases in Somalia.In June and July alone, 1,633 acute watery diarrhea cases had been registered in Banadir Hospital, Mogadishu, representing 38 percent of all reported cases in 2011, and a sharp rise comparing with the same period last year.The United Nations public health arm said the situation was related to poor sanitation and limited access to safe water in numerous informal IDP settlements and a limited capacity of existing health partners to access those settlements and provide essential health services.In addition, the high number of malnourished children due to the ongoing famine increased the susceptibility to waterborne diseases.

WASHINGTON, June 21 (Xinhua) -- A new study from Harvard School of Public Health (HSPH) and University of California, San Francisco, researchers suggests that men with prostate cancer who smoke increase their risk of prostate cancer recurrence and of dying from the disease. The study will be published Wednesday in the Journal of the American Medical Association."In our study, we found similar results for both prostate cancer recurrence and prostate cancer mortality," said Stacey Kenfield, lead author and a research associate in the HSPH Department of Epidemiology. "These data taken together provide further support that smoking may increase risk of prostate cancer progression."Kenfield and her colleagues conducted a prospective observational study of 5,366 men diagnosed with prostate cancer between 1986 and 2006 in the Health Professionals Follow-Up Study. The researchers documented 1,630 deaths, 524 (32 percent) due to prostate cancer, 416 (26 percent) due to cardiovascular disease, and 878 prostate cancer recurrences.The researchers found that men with prostate cancer who were current smokers had a 61 percent increased risk of dying from prostate cancer, and a 61 percent higher risk of recurrence compared with men who never smoked. Smoking was associated with a more aggressive disease at diagnosis, defined as a higher clinical stage or Gleason grade (a measure of prostate cancer severity). However, among men with non-metastatic disease at diagnosis, current smokers had an 80 percent increased risk of dying from prostate cancer.Compared with current smokers, men with prostate cancer who had quit smoking for 10 or more years, or who had quit for less than 10 years but smoked less than 20 pack-years before diagnosis, had prostate cancer mortality risk similar to men who had never smoked. Men who had quit smoking for less than 10 years and had smoked 20 or more pack-years had risks similar to current smokers."These data are exciting because there are few known ways for a man to reduce his risk of dying from prostate cancer," said senior author Edward Giovannucci, professor of nutrition and epidemiology at HSPH. "For smokers, quitting can impact their risk of dying from prostate cancer. This is another reason to not smoke."Prostate cancer is the most frequently diagnosed form of cancer diagnosed in the United States and the second leading cause of cancer death among U.S. men, affecting one in six men during their lifetime. More than two million men in the U.S. and 16 million men worldwide are prostate cancer survivors.
BEIJING, Sept. 8 (Xinhuanet) -- Middle-aged white women drinking alcohol moderately are more likely to stay healthy than nondrinkers, according to a new study from Harvard.The study has followed about 14,000 mostly white women since 1976.As a result, compared with teetotalers, those who had 3 to 15 alcoholic drinks weekly in their late 50s were 28 percent higher of being free from physical disability, chronic illness, mental health problems, and cognitive decline at the age of 70.Even having just one or two drinks per week increased a woman's odds of good health by 11 percent.However, women should be aware that even moderate drinking has been linked to an increased risk of breast cancer, said Qi Sun, M.D., a lead author of the study and a nutrition researcher at the Harvard School of Public Health.These findings don't necessarily apply to men or to nonwhite women. But they reinforced the evidence for the health benefits of moderate drinking.
SINGAPORE, July 10 (Xinhua) -- The upcoming Natural History Museum in Singapore launched a drive on Sunday to raise 12 million Singapore dollars (9.8 million U.S. dollars) by the end of the month to buy three dinosaur fossils from a company in Wyoming, the United States.The three dinosaurs on offer from the company Dinosauria International, thought to be a family, were found between 2007 and last year in the United States, the Straits Times reported on Sunday.Appollo and Prince, the two adult diplodocid sauropods, is about 24 meters long, while the baby Twinky is about 12 meters.The natural history museum is expected to be completed by 2014. The three dinosaur fossils will cost 870 million Singapore dollars, and an additional 370 million Singapore dollars will be spent to set up the exhibition."They wanted the museum to tell the story of the history of life and evolution. Dinosaurs are the history of life," said Professor Peter Ng, director of the Raffles Museum of Biodiversity Research, referring to the approval from the scientific advisory committee for the acquisition.The Raffles Museum of Biodiversity Research of the National University of Singapore went on an intensive fund raising campaign last year to build the dedicated Natural History Museum.The museum said it has found the amount to be challenging. It is therefore appealing for help from the public through the media."The idea was always to have a central gallery and put something there that would make people go 'Whoa!,'" said Ng.
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