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WASHINGTON, April 25 (Xinhua) -- A class of drugs that shows promise in breast and ovarian cancers with BRCA gene mutations could potentially benefit colorectal cancer patients with a different genetic mutation, a new study from the University of Michigan Comprehensive Cancer Center finds.Working in cell lines from colorectal cancer patients, researchers found that the class of drugs called PARP inhibitors worked against tumors with mutations in the MRE11 gene.About 15 percent of all colorectal cancers have what's called microsatellite instability, a type of error in the DNA. About 82 percent of those tumors have the MRE11 gene mutation."This is a potential broader application for PARP inhibitors, beyond breast and ovarian cancer. This is a class of drug that's already shown safety in early clinical trials and now might benefit some colorectal cancer patients as well," says lead study author Eduardo Vilar-Sanchez, a hematology/oncology fellow at the university, in a statement.The study, which was published Monday in Cancer Research, also found that PARP inhibitors are even more effective when both copies of MRE11 were mutated. Each person carries two copies of each gene, which means mutations can occur in either one or both copies. The researchers suggest that PARP inhibitors could be targeted specifically to colorectal cancer patients who have two copies of the mutated gene.Researchers are planning a phase I clinical trial to look at using PARP inhibitors in colorectal cancer patients with two mutated copies of MRE11. Future trials are being considered using PARP inhibitors to prevent colorectal cancer and other cancers in people with Lynch syndrome whose tumors have this mutation.Microsatellite instability is also seen in prostate cancer and endometrial cancer, suggesting potential for PARP inhibitors to play a role in additional types of cancer as well, Vilar-Sanchez says, adding that more research is needed in these areas.

WASHINGTON, May 27 (Xinhua) -- The U.S. Treasury Department said in a report released on Friday that China was not manipulating its currency."In China, since the authorities decided in June 2010 to allow the exchange rate to appreciate in response to market forces, the renminbi (RMB) has appreciated by a total of 5.1 percent against the dollar in nominal terms through the end of April 2011, or at an annual pace of approximately 6.0 percent," noted the semi- annual report on international economic and exchange rate policies.The Treasury said that as inflation in China is significantly higher than it is in the United States, the renminbi has appreciated more rapidly against the dollar on a real, inflation- adjusted basis, at a rate of around 9 percent per year.The delayed report, which was originally scheduled to be sent to the Congress on April 15, finds "no major trading partner of the United States" manipulated its currency during the period covered in the report.The Treasury added that it will continue to "closely monitor" the renminbi appreciation pace.The report also noted that the U.S. economy is recovering from its deepest recession in the post-war period."While recent growth is encouraging, the economy still faces significant challenges," said the report. The number one challenge is still in the labor market.The U.S. unemployment rate, currently at 9.0 percent, is not expected to fall significantly this year.Besides, housing market and long-term fiscal position are " unsustainable," according to the report.In recent remarks, Treasury Secretary Timothy Geithner stated that China is the fastest growing market for U.S. exports. In 2010, U.S. exports to China grew at a pace that was 50 percent higher than the rest of the world.

LOS ANGELES, April 1 (Xinhua) -- A NASA Gulfstream-III aircraft equipped with a synthetic aperture radar is scheduled to depart Sunday, April 3 on a nine-day mission to image Hawaii volcanoes, the Jet Propulsion Laboratory (JPL) announced on Friday.The aircraft will fly from the Dryden Aircraft Operations Facility in Palmdale, California to the Big Island of Hawaii to study the Kilauea volcano that recently erupted, said JPL in Pasadena, Los Angeles.The mission will help scientists better understand processes occurring under Earth's surface, JPL said.Developed by JPL, the Uninhabited Aerial Vehicle Synthetic Aperture Radar, or UAVSAR, uses a technique called interferometric synthetic aperture radar that sends pulses of microwave energy from the aircraft to the ground to detect and measure very subtle deformations in Earth's surface, such as those caused by earthquakes, volcanoes, landslides and glacier movements.As the Gulfstream-III flies at an altitude of about 12,500 meters, the radar, located in a pod under the aircraft's belly, will collect data over Kilauea, according to JPL.The UAVSAR's first data acquisitions over this volcanic region took place in January 2010, when the radar flew over the volcano daily for a week. The UAVSAR detected deflation of Kilauea's caldera over one day, part of a series of deflation-inflation events observed at Kilauea as magma is pumped into the volcano's east rift zone.This month's flights will repeat the 2010 flight paths to an accuracy of within 5 meters, or about 16.5 feet, assisted by a Platform Precision Autopilot designed by engineers at NASA's Dryden Flight Research Center on Edwards Air Force Base, California, JPL said.By comparing these camera-like images, interferograms are formed that reveal changes in Earth's surface, said JPL.Between March 5 and 11, 2011, a spectacular fissure eruption occurred along the east rift zone. Satellite radar imagery captured the progression of this volcanic event."The April 2011 UAVSAR flights will capture the March 2011 fissure eruption surface displacements at high resolution and from multiple viewing directions, giving us an improved resolution of the magma injected into the east rift zone that caused the eruption," said JPL research scientist Paul Lundgren."Our goal is to be able to deploy the UAVSAR on short notice to better understand and aid in responding to hazards from Kilauea and other volcanoes in the Pacific region covered by this study," Lundgren added.

BEIJING, Feb. 17 (Xinhua) -- China's new rules for reviewing proposed mergers and acquisition (M&A) deals by foreign firms on grounds of national security would benefit both Chinese and foreign investors, a Ministry of Commerce (MOC) spokesman said Thursday.The rules will facilitate the growth of foreign-invested enterprises (FIEs) in China and improve the quality and structure of foreign direct investment (FDI) flowing into China, MOC spokesman Yao Jian said at a press conference.The move also marked an improving legal environment for the security of China's business sector along with its opening-up drive, given that M&A by FIEs will increasingly become a trend in the coming years, Yao said."The adoption of the rules in China will also increase policy transparency and improve law-based government administration," said Yao.Yao's words came after the State Council, China's Cabinet, announced last Saturday that it was establishing a panel to check whether M&A deals struck by foreign firms in the country endanger national security.The panel will review attempts by FIEs to buy or merge with domestic companies whose business pertains to national defence, agriculture, energy, resources, key infrastructure, transport systems, key technology sectors and important equipment manufacturing industries, according to a statement published on the central government's website www.gov.cn.The review will be conducted by a foreign investment security review board under the cabinet, members of which come from the National Development and Reform Commission (NDRC), the MOC and other agencies.The new regulations, which take effect in March, come at a time when China is expected to see more M&A deals struck by foreign firms.Currently, inward M&A accounts for about 3 percent of China's total FDI, a sharp contrast with the global average level of more than 70 percent, said Yao. "M&A by FIEs will become a major trend in China."China's taking in FDI through more M&A will promote industrial consolidation and restructuring, and it will also mean more efficient utilization of the existing resources, he said."As the share of M&A in the FDI will probably rise from the current 3 percent to 8 percent, 10 percent or even more, it is necessary to timely formulate China's own rules governing foreign takeovers in line with international standards," Yao said.In April 2010, the State Council said in a statement that foreign investment should be allowed to be more diversified and foreign investors encouraged to participate in the consolidation and restructuring of domestic firms via equity holdings or acquisitions.He Manqing, a researcher with the Chinese Academy of International Trade and Economic Cooperation of the MOC, said "It is right and proper to impose regulations and requirements on proposed M&A deals in the sectors of strategic importance and those involving national security.""The introduction of the regulations conforms to the new trend in China's receiving of FDI and indicates that China's regulations on FDI are becoming more mature," said He.The NDRC said Wednesday that national security scrutiny would only occur when foreign companies take a majority stake in a domestic M&A deal, meaning that a minority stake purchase will not trigger a review."The new rules draw references from similar rules in the United States, Germany and Canada," the NDRC said in a statement on its website.The NDRC also said that the new regulations were in line with World Trade Organization rules and did not imply that China had changed its policies on opening up and attracting FDI.China's FDI jumped 23.4 percent in January to 10.03 billion U.S. dollars, said Yao. The monthly growth rate was up from December's 15.6 percent.As the world's top investment destination, China received a total of 105.74 billion U.S dollars in FDI in 2010, up 17.4 percent year on year, the MOC said last month.

MEXICO CITY, May 18 (Xinhua) -- The Mexican government signed an agreement with the non-governmental group TRAFFIC on Tuesday to exchange information about illegal seizures of flora and fauna species in Mexico.The agreement with the wildlife trade monitoring network also called for the Mexican government to provide information on the routes used to transport such organic materials.The agreement was signed on the sideline of the 16th meeting of the Trilateral Committee for Wildlife and Ecosystem Conservation Management in the city of Oaxaca, south Mexico. Representatives of Canada, the United States and Mexico also attended the meeting.Among the list of 20,000 animals, vegetation and insects that TRAFFIC considers to be threatened by illegal trafficking worldwide, 2,500 of the organisms have their origins in Mexico. This amounts to 12 percent of the species most subject to buying, selling and transporting in the black market and threatens the survival of various ecosystems.The Mexican species that are listed among the most threatened by illegal trafficking are the cactus, orchids, reptiles, maguey plants, ferns, amphibians and fish.

来源：资阳报