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LONDON — U.K. regulators say people who have a “significant history’’ of allergic reactions shouldn’t receive the new Pfizer-BioNTech vaccine while they investigate two adverse reactions that occurred on the first day of the country’s mass vaccination program. Stephen Powis, the national medical director for the U.K.'s National Health Service in England said Wednesday that health authorities were acting on a recommendation from the Medical and Healthcare Products Regulatory Agency. He says the agency has advised, on a precautionary basis, that "people with a significant history of allergic reactions do not receive this vaccination." Powis added that both people are recovering well.Dr. June Raine, head of the U.K.'s Medical and Healthcare Products Regulatory Agency, told Parliament on Wednesday that the reactions were not seen in clinical trials for the drug.“We know from the very extensive clinical trials that this wasn’t a feature,” Raine said, according to the Associated Press. “But If we need to strengthen our advice, now that we have had this experience with the vulnerable populations, the groups who have been selected as a priority, we get that advice to the field immediately.The FDA is currently weighing whether to approve the Pfizer-BioNTech vaccine for emergency use in the United States. 1325

LOS ANGELES (AP) — U.S. investigators on Thursday were examining potential ignition sources of a deadly fire on a scuba diving boat, including electronics aboard the vessel where 34 people were killed off the coast of Southern California.Investigators know photography equipment, batteries and other electronics were stored and plugged in on the Conception, said Jennifer Homendy, a member of the National Transportation Safety Board."We are not ruling anything out at this point," she said.Homendy also said she had inspected a vessel similar to the Conception and was concerned about the accessibility of its emergency exit hatch and possible difficulties getting to safety.The victims died after flames above deck blocked the one stairway and the hatch leading from sleeping bunks to the upper decks and gave those below virtually no chance of getting out, authorities have said.RELATED: San Diego woman killed in deadly Conception boat fire off Santa BarbaraThe Conception had been in full compliance with Coast Guard regulations, officials said.The federal investigation continued as divers resumed a search for the last victim who remained missing. Divers have pulled 33 bodies from the seabed and the charred wreckage of the sunken, overturned boat.California Gov. Gavin Newsom identified two of the victims as Adrian Dahood-Fritz and her husband Andrew Fritz. Dahood-Fritz had worked for the California Natural Resources Agency's Ocean Protection Council since April as a senior environmental scientist."Adrian led the state's efforts to manage California's network of marine protected areas, and she cared deeply about the ocean and biodiversity," Newsom said in a statement. "She embodied marine conservation and was a highly accomplished and respected scientific researcher."The other victims included two high schoolers, a hairdresser, marine biologist, software engineers, special effects designer for Disney, nature photographer, nurse and family of five celebrating a birthday.RELATED: Celebration of life to be held at Coronado restaurant for San Diego woman killed in boat fireTheir common love of scuba diving led them to the ruggedly beautiful coastline of the Channel Islands for a three-day excursion planned through Labor Day.Five crew members, including the captain, were above deck and managed to escape. Officials said they expected to interview the captain Thursday.The only crew member to die was Allie Kurtz, 26, who quit her corporate job at Paramount Pictures to work on dive boats. Kurtz, who grew up in Illinois, had recently been promoted to deckhand."Her love was just always, always the water," Kurtz's grandmother, Doris Lapporte, 71, said. "She would joke, 'I am going to be a pirate one day.'"Four crew members were given tests for alcohol, which were negative, and all five survivors had drug tests and the results are pending, Homendy said.The Conception wasn't required by federal regulations to have fire sprinklers aboard, according to the U.S. Coast Guard.Other California divers have said Truth Aquatics, which owned the Conception, and its captains were very safety-conscious and the tragedy shocked the industry.Cheryl Babineau, owner of Pro Scuba Dive Center in Scotts Valley, California, and a certified diver for 45 years, said boat passengers sometimes tune out when the captain and crewmembers review safety instructions for a dive trip. She expects that will change. "I think now people will pay a lot more attention," she said. The boat's owner and others were interviewed for hours as the National Transportation Safety Board investigated the fire, Homendy has said.Those killed included Apple engineer Steve Salika and his wife, Diana Adamic, who went on the trip with their daughter Tia Salika to celebrate her 17th birthday, company senior vice president Deirdre O'Brien told The Mercury News newspaper. Apple colleague Dan Garcia joined them.Tia was with Berenic Felipe, a fellow student at Pacific Collegiate Charter School in Santa Cruz, according to a letter sent to the school community obtained by NBC News.Also aboard was visual effects designer Charles McIlvain, who was known for his work on films such as "Spider-Man" and "Green Lantern."Lisa Fiedler was a 52-year-old hairdresser and photographer from Mill Valley, north of San Francisco, her mother, Nancy Fiedler, told San Francisco's ABC affiliate, KGO television.San Francisco-based education platform Brilliant confirmed that senior software engineer Carrie McLaughlin and Kristian Takvam, vice president of engineering, were aboard. 4565

LOS ANGELES (AP) — Paul and Jamie Buchman are picking up where they left off 20 years ago on "Mad About You."On-demand service Spectrum Originals said Wednesday a limited series will bring Helen Hunt and Paul Reiser back as the New York City couple.The original series, which aired from 1992 to 1999, followed the Buchmans as newlyweds through early parenthood.The sequel will explore modern marriage from the perspective of empty nesters, Spectrum said. It's set to debut in late 2019.In a statement, Hunt and Reiser promised the same funny, heartwarming show, adding, "as soon as we can remember what's funny about being older."Danny Jacobson, who co-created the show with Reiser, is a consultant.Spectrum Originals is launching this spring with the Gabrielle Union-Jessica Alba drama series "L.A.'s Finest." 818

LONDON (AP) — British Prime Minister Boris Johnson says Christmas gatherings can’t go ahead and non-essential shops must close in London and much of southern England as he imposed a new, higher level of coronavirus restrictions to curb sharply spreading infections. Johnson said the capital and other areas in southern England will move to an even stricter Tier 4 alert category that requires non-essential shops, hairdressers and indoor leisure venues to close after the end of business hours Saturday. Johnson also said that a planned five-day easing of socializing rules that would allow up to three households to meet in “Christmas bubbles” will be canceled for Tier 4 areas. In the rest of England, people will be allowed to meet in Christmas bubbles for just one day instead of five, as the government originally planned.“It is with a very heavy heart that I must tell you we cannot proceed with Christmas as planned,” Johnson said.A fast-moving new variant of the coronavirus that is more than 70% more transmissible than existing strains appears to be driving the rapid spread in London and southern England, Johnson said. London now has the highest infection rates in England.“There’s no evidence to suggest it is more lethal or causes more severe illness,” he stressed, or that vaccines will be less effective against it.England’s chief medical officer, Chris Whitty, said the U.K. has alerted the World Health Organization that the new variant identified this week appears to be accelerating the spread of COVID-19. The government’s scientific advisers came to that conclusion based on preliminary modelling figures, and they are continuing to analyze the available data, he said. 1699

LOS ANGELES (AP) — Malik B, a rapper and founding member of The Roots, has died. He was 47. The group announced the death of the Philadelphia-based emcee in a social media post on Wednesday. The cause of death has not been released. Malik B, whose real name is Malik Abdul Basit, was a major contributor to the group, which includes Ahmir "Questlove" Thompson and Tariq "Black Thought" Trotter. He appeared on four albums before departing the group in 1999. In the following year, the Roots won their first Grammy. 522