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The United States is on pace to see its highest number of overdose deaths ever since record keeping began.Between October 2019 and October 2020, 74,000 overdose deaths were reported in the country, up from 68,000 during the same time period the previous year.In local municipalities, the numbers are even more staggering as many cities already surpassed their 2019 numbers through the first nine months of this year, and experts say the pandemic is only fueling the rise.The Associated Press analyzed preliminary overdose statistics in nine states across the country: Colorado, Kentucky, Texas, Connecticut, Massachusetts, Missouri, Rhode Island, New Jersey, and Washington. All of the states showed marked increased in overdose numbers from 2019 to 2020.In Colorado, for example, overdose deaths increased by 28%. In Denver, specifically, that rise was being fueled by the opiate fentanyl, which has been trafficked more across the U.S. Mexico border during the pandemic due to its strength.According Denver’s Medical Examiner’s Office, fentanyl deaths increased tenfold between 2018 and 2020. In 2019, the city reported 56 overdoses from the drug. Through October of this year, that number has skyrocketed to 108.“Drug overdoses are exceeding every metric that we’ve seen for the last decade,” said Dr. Jim Caruso, who is the coroner for the City and County of Denver. “We have had fentanyl related deaths in individuals as young as nine years old. Kids are always tough and they’ve been tough my whole career because you’re looking at the most lost years of productive life.”Dr. Ken Leonard is the Director of the Research Institute on Addictions at the University of Buffalo and says since the start of the pandemic, overdose deaths have only increased at a faster rate, particularly among those with existing drug issues.According to the AP’s analysis, deaths in all nine states peaked in either April or May, just after the tightest stages of quarantine began.Dr. Leonard says the economic consequences of the pandemic forced many drug treatment centers to either furlough or cut employees to save money, affecting accessibility to treatment. He says the isolation from support networks during quarantine may have also played a role in the rise.“The pandemic and the isolation, for a lot of people the unemployment, it all creates a tremendous amount of stress,” said Leonard.Because it takes months to tabulate national overdose death numbers, the true extent of what is happening may not be known until next year, despite early indicators that we are already in the midst of an unprecedented drug epidemic taking place during this pandemic. 2656

The sports complex sheltering thousands of Central American migrants in this Mexican border city is well above its capacity, and more migrants are expected to arrive in the coming days.More than 5,800 migrants have taken shelter in the Benito Juarez Sports Complex, according to Mexico's Social Development Secretariat.That's at least three times above the facility's capacity, said Rodolfo Olimpo, a representative from Baja California state's Special Committee on Migration Issues.State and municipal officials are looking to open another shelter, Olimpo said, but they haven't found any local business or space willing to rent out their facilities for the migrants.CNN crews that visited the Benito Juarez shelter found squalid conditions, including open sewage drains. Many people appeared restless and nervous.Inside the sports complex, which has become the main facility sheltering migrants in Tijuana, migrants wait for hours in long lines for food. Tents cover sports fields and spill outside the facility's gates.Many migrants say they're waiting for the chance to seek asylum in the United States. Given the massive backlog at the nearby port of entry, it could be weeks before they have a chance to cross the border and begin to make their case.Meanwhile, the Mexican Red Cross has been providing medical assistance for migrants in the shelter. The Mexican navy has set up two small kitchens nearby the shelter, Olimpo said, and the federal government has installed two water plants.But Amnesty International said on Monday the shelter doesn't have enough resources for migrants housed there, describing conditions as "unsanitary.""Mexican federal, state and municipal officials separately confirmed to Amnesty International that the temporary shelter did not have sufficient food, water and health services, and that respiratory illnesses were spreading among those staying there," Amnesty said.Tijuana's mayor has described the situation as a crisis and called for humanitarian help.The growing number of migrants in Tijuana, a city of about 2 million people just south of California, is "a big problem" that "we are not capable of solving," Mayor Juan Manuel Gastélum told CNN.The Mexican federal government -- with a new president due to be installed Saturday -- or the United Nations must step in, the mayor said, to "give us shelter, give them food, water, medicines, everything that a person needs to be dignified and have a place where they can stay dignified." 2488

The U.S. regulators who will decide the fate of COVID-19 vaccines are taking an unusual step: Asking outside scientists if their standards are high enough.The Food and Drug Administration may have to decide by year’s end whether to allow use of the first vaccines against the virus. Thursday, a federal advisory committee pulls back the curtain on that decision process, debating whether the guidelines FDA has set for vaccine developers are rigorous enough.“We will not cut corners, and we will only use science and data to make that determination,” FDA Commissioner Stephen Hahn pledged at a meeting of the Milken Institute Wednesday.Exactly how much data his agency needs to be sure a vaccine is safe and effective is a key question for the advisers. An even bigger one: If the FDA allows emergency use of a vaccine before final testing is finished, will that destroy chances of ever learning just how well that shot -- and maybe competitors still being studied -- really work?“We can’t lose sight of the fact that it is in our societal interest to see these trials to completion,” said Dr. Luciana Borio, a former FDA acting chief scientist who will be watching the advisers’ debate.Plus, multiple vaccines are being studied -- shots made with different technologies that each have pros and cons.“The first vaccine is not necessarily the best vaccine,” cautioned Dr. M. Miles Braun, a former FDA scientist now with Georgetown University School of Medicine. If the trials aren’t allowed to finish, it may be difficult or impossible to ever know for sure.It’s a critical moment in FDA’s 114-year history. The government has spent billions to race a vaccine through a research process that usually takes years, and FDA faces unprecedented pressure from the Trump administration, fueling public skepticism that politics could overrule science.Interest is so high, FDA is airing the meeting on YouTube. Here are some key issues the committee will discuss:HOW MUCH EVIDENCE IS NEEDED?FDA is requiring manufacturers to do studies of at least 30,000 people to prove if a vaccine protects and how safe it is. Those studies must include adequate numbers of people at highest risk from COVID-19 -- older adults, minorities and anyone with underlying health problems.FDA has made clear that any vaccine must be at least 50% effective. And while the studies are designed to run for two years, companies may get enough evidence the shots are protective -- in at least some people -- to stop the trials early and seek what’s called an “emergency use authorization” for wider vaccinations.Despite White House objections, the FDA told vaccine makers earlier this month not to seek that speedier review until they’ve tracked at least half their trial participants for two months. With other vaccines, that’s about the amount of time when major side effects crop up.That’s not long enough, said the head of the non-profit ECRI Institute, which reviews medical technology for hospitals and insurers. In comments submitted to the advisory committee, ECRI’s Dr. Marcus Schabacker said FDA should require six months of follow-up.“Doing any less would simply risk too much, and the consequences may be severe,” he wrote. “A weak vaccine that loses public trust could poison the well for epidemic control for many years.”WOULD EMERGENCY USE DERAIL FULL ANSWERS ABOUT VACCINES?Normally when a study ends because of evidence that a vaccine is working, the participants who got dummy shots are offered the real thing.But if FDA allows emergency use of a COVID-19 vaccine, that’s not the same as having full proof the shot works, Borio cautioned.And if the participants in the placebo group are immediately offered the real shot, researchers may not be able to get answers about all the high-risk groups in the study — or tell how long the vaccine’s protection lasts, a process expected to take many more months.But Pfizer Inc., which with Germany’s BioNTech is developing one of the leading candidates, told FDA that if it’s granted emergency use authorization, it “would have an ethical obligation” to alert study participants who got a placebo and allow them vaccine access. The company wants FDA to look into “other scientifically and statistically sound methods” to determine long-term safety and effectiveness.Pfizer’s stance is likely to face pushback. The Infectious Diseases Society of America states that FDA’s panelists “should insist” that vaccine developers “present a compelling case” for how they will complete their trials if FDA grants early authorization of their vaccine.Clearing a vaccine based on premature or faulty data “could cause more harm” by “further eroding public confidence in all vaccines,” the group said.It’s an unprecedented dilemma. The FDA has previously allowed emergency use of only one vaccine, a decades-old shot that in 2005 was authorized to prevent anthrax poisoning.This time around, multiple COVID-19 vaccines are in the pipeline. Pfizer competitor Johnson & Johnson cautioned that early FDA clearance of one vaccine could “jeopardize integrity” of other ongoing trials if patients decide to drop out to seek the first cleared shot instead.The company asked regulators to explain what options are available to ensure completion of all ongoing COVID-19 vaccine trials.WHAT ABOUT LONG-TERM SAFETY MONITORING?Even a study of 30,000 people cannot spot a side effect that only strikes 1 in 100,000. So the government is planning extra scrutiny of every COVID-19 vaccine to hit the market.At first there will be limited doses given to just certain high-risk people -- and those early recipients are to get text messages daily for the first week after vaccination, and then weekly out to six weeks, asking how they’re feeling.FDA also will be checking databases of electronic health records and insurance claims, looking for any red flags.“There’s a kind of tracking that has to take place here on a massive basis that hasn’t taken place before,” said Dr. Jesse Goodman of Georgetown University, a former director of the FDA’s vaccine and biologics center.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 6274

The U.S. Marine Corps says it has lifted a "shelter-in-place" order at the Air Ground Combat Center (AGCC) in Twentynine Palms, California following earlier reports of an "active shooter."According to a statement from the Marines, the order was enacted when an "individual" suffered a self-inflicted gunshot wound on the base at about 8:30 a.m. PT. No other injuries were reported. The person who fired the gun has been transported to a local medical center for treatment.The Marines say they are investigating.Shortly after 8:30 a.m., the Marines tweeted that they were "aware of reports" of an active shooter at the AGCC. Later, both KESQ-TV in Palm Springs, California and KTTV-TV in Los Angeles reported — citing a base spokesperson — that a suspect had been taken into custody and that there were no reports of injuries. The Marines later disputed those reports, saying that it could not confirm that a suspect was in custody.The base is located about an hour's drive northwest of Palm Springs. 1008

The weekend didn't make things any easier for students of Marjory Stoneman Douglas High School: Parents had to lay teen children to rest; the family who had taken in shooter Nikolas Cruz said they didn't know they were living with a "monster;" and a tweet from President Donald Trump seemed to infuriate an already-angry student body.The students promised action in the wake of the massacre that left 17 of their classmates and teachers dead. They're headed to Tallahassee, Florida, to speak to legislators about school safety and gun control this week, and they have school walkouts and a march scheduled in the coming months.Meanwhile, Anthony Borges, 15, continued his recovery. He's one of four patients who remain hospitalized after Wednesday's massacre in Parkland, Florida. He was shot five times, according to the Broward County Sheriff's Office.  868