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A genetic analysis of COVID-19 patients suggests that blood type might influence whether someone develops severe disease.Scientists who compared the genes of thousands of patients in Europe found that those who had Type A blood were more likely to have severe disease while those with Type O were less likely.Wednesday’s report in the New England Journal of Medicine does not prove a blood type connection, but it does confirm a previous report from China of such a link.“Most of us discounted it because it was a very crude study,” Dr. Parameswar Hari, a blood specialist at the Medical College of Wisconsin, said of the report from China. With the new work, “now I believe it,” he said. “It could be very important.”Other scientists urged caution.The evidence of a role for blood type is “tentative ... it isn’t enough of a signal to be sure,” said Dr. Eric Topol, head of the Scripps Research Translational Institute in San Diego.The study, involving scientists in Italy, Spain, Denmark, Germany and other countries, compared about 2,000 patients with severe COVID-19 to several thousand other people who were healthy or who had only mild or no symptoms. Researchers tied variations in six genes to the likelihood of severe disease, including some that could have a role in how vulnerable people are to the virus. They also tied blood groups to possible risk.Most genetic studies like this are much larger, so it would be important to see if other scientists can look at other groups of patients to see if they find the same links, Topol said.Many researchers have been hunting for clues as to why some people infected with the coronavirus get very ill and others, less so. Being older or male seems to increase risk, and scientists have been looking at genes as another possible “host factor” that influences disease severity.There are four main blood types — A, B, AB and O — and “it’s determined by proteins on the surface of your red blood cells,” said Dr. Mary Horowitz, scientific chief at the Center for International Blood and Marrow Transplant Research.People with Type O are better able to recognize certain proteins as foreign, and that may extend to proteins on virus surfaces, Hari explained.During the SARS outbreak, which was caused by a genetic cousin of the coronavirus causing the current pandemic, “it was noted that people with O blood type were less likely to get severe disease,” he said.Blood type also has been tied to susceptibility to some other infectious diseases, including cholera, recurrent urinary tract infections from E. coli, and a bug called H. pylori that can cause ulcers and stomach cancer, said Dr. David Valle, director of the Institute of Genetic Medicine at Johns Hopkins University.Bottom line: “It’s a provocative study. It’s in my view well worth publishing and getting out there,” but it needs verification in more patients, Valle said.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 3086

A church shooting?killing at least 26?in?Sutherland Springs, Texas marks the 307 mass shooting in the United States so far this year.According to data from the Gun Violence Archive, a total of 307 mass shooting incidents have occurred as of November 5, up 27 from one month ago.Comparatively, 2016 saw a total of 483 mass shootings. See statistics for other years here. 397

A man has died in Alabama as a result of Hurricane Sally, according to several media outlets.The Weather Channel reported the unidentified man died in Orange Beach, Alabama.Orange Beach Mayor Tony Kennon confirmed to WVTM that a person is missing.The National Hurricane Center reported that the slow-moving storm made landfall near Gulf Shores, Alabama, on Wednesday at 5:45 a.m. ET with maximum sustained wind speeds of 105 mph. 437

A lock of Abraham Lincoln’s hair, wrapped in a bloodstained telegram about his 1865 assassination, is up for sale. Boston-based RR Auction says bidding has opened online for the items ahead of a live auction scheduled for Sept. 12. Measuring roughly 2 inches long, the bushy lock of hair was removed during Lincoln’s postmortem examination after he was fatally shot at Ford’s Theatre in Washington, D.C., by John Wilkes Booth. The auction house says it was given to Dr. Lyman Beecher Todd, a Kentucky postmaster and a cousin of Mary Todd Lincoln, the 16th president’s widow. 582

A late snow in a small town might slow down the traffic, but it can't delay the final days for one of the community's gathering spots."This is when they see each other," said Parkman Township, Ohio Trustee Dennis Ikeler. "At the post office."Ikeler says after decades leasing out the building to the post office, the landlords told the township they don't think the building is safe enough for the public. They terminated the lease with a 30-day notice. The U.S. Postal Service says they'll be out by April 28th.The problem is that a lot of homes in the center of the town don't have any curbside delivery or mailboxes to receive mail. The more than 200 boxes inside the small post office have been their only option. When the building closes at the end of the month, they'll have the option to pay for individual boxes at their homes or have their P.O. box transferred to the Middlefield, Ohio Post Office, about seven miles away.Ikeler says traveling a few miles for mail isn't a big deal for most people he's talked to, but Catherine Dudich says it could be an issue for others."There's quite a lot of elderly people that live in the community and they can't get out every day to go get their mail," said Dudich. "It's sad that all these little communities are going by the wayside."Parkman residents say their P.O. Boxes have been free when they are normally rented out for a few months at a time. Residents say they've been told they'll continue to get their P.O. Boxes free of charge, even once they move to another location. 1544

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