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WASHINGTON, April 4 (Xinhua) -- New research from the University of Pennsylvania School of Medicine has revealed an increased incidence of major adverse cardiac events (MACE), such as heart attack, stroke, and cardiovascular death, in patients with severe psoriasis. The study results were reported Monday at the annual American College of Cardiology meeting in New Orleans.Psoriasis is a common inflammatory skin disease, and if severe, has been demonstrated to be a risk factor for cardiovascular disease. However, the degree to which psoriasis is associated with MACE has not been defined.In a cohort study analyzing data from a general practice research database, Lead author Nehal Mehta, director of Inflammatory Risk in Penn's Preventive Cardiology program, and colleagues reviewed the case histories of over 3,600 patients with severe psoriasis and 14,300 controls. They found that patients with severe psoriasis have a 53 percent increased incidence of MACE compared to the general population. They also found that having a diagnosed case of severe psoriasis confers an additional ten-year risk of six percent on MACE.Previous work from Mehta and colleagues found that the risk of death from cardiovascular disease increased by 57 percent in patients with severe psoriasis. In addition, the relative risk of death from cardiovascular disease was even higher in younger patients, who were as young as age 40.The researchers conclude that this new estimate of increased ten-year MACE may warrant more aggressive strategies for treatment of cardiovascular risk factors in patients with psoriasis.

BEIJING, April 12 (Xinhuanet) -- The elderly have a difficult time with multi-tasking as a study suggests that older brains behave differently when it comes to switching between two tasks, according to media reports on Tuesday.Researchers used functional magnetic resonance imaging (FMRI) to analyze brain activity in 20 people over age 60 by asking them to contemplate outdoor photos shown briefly. Then the elderly were presented with the picture of a face and asked to determine its gender and age, before being asked to recall details from the original scene they viewed.Researchers then compared their results to a similar experiment with 20 younger adults and found the brains of older subjects were less capable of disengaging from the interruption and reestablishing the neural connections necessary to switch back to focusing on the original memory."Unlike younger individuals, older adults failed to both disengage from the interruption and re-establish functional connections associated with the disrupted memory network," write Wesley C. Clapp of the University of California, San Francisco, and colleagues in the Proceedings of the National Academy of Sciences.The study, published in the online edition of the journal Proceedings of the National Academy of Sciences, sheds new lights into a growing body of studies showing that one's ability to move from one task to another in quick succession becomes more difficult with age.

WELLINGTON, May 13 (Xinhua) -- While it's long been known that a little sunshine can spread happiness, researchers in New Zealand have found that it can also save the lives of pneumonia patients.Medical scientists have found that vitamin D, which is absorbed through the skin and produced with exposure to sunlight, is a major factor in the survival rate of pneumonia patients.Researchers at Waikato University collaborated with doctors at Waikato Hospital, both Hamilton-based institutions, to study blood samples of 112 patients admitted to the hospital with pneumonia during the winter.They found that those with severe vitamin D deficiency 17 of the patients were more likely to die within a month, compared with patients with normal or slightly low vitamin D levels.Dr Bob Hancox, of the hospital's department of respiratory medicine, said five of the 17 died, a 29-percent mortality rate, compared with four deaths among the 95 patients with higher vitamin D levels, a 4-percent mortality rate."The analysis confirmed that the difference in mortality rates between the two groups was very unlikely to be due to chance," Hancox told Xinhua.Vitamin D deficiency was a concern around the world, Hancox said."Sunlight is the main source of vitamin D, so it tends to be a winter problem in temperate climates when people spend a lot of time indoors. But it occurs in all countries and vitamin D deficiency is believed to be a major problem worldwide."There is accumulating evidence that we need vitamin D to help fight infections, such as pneumonia as we have shown, as well as improve bone health," he told Xinhua."What is not yet clear is whether we can do anything about it. We don't know whether treating people with vitamin D supplements would help to prevent or treat respiratory infections. This is what we need to find out now."Dr Ray Cursons, of the Biological Sciences department at Waikato University, said patient age, sex, additional health conditions, and other prognostic factors did not affect the research outcome, although researchers still could not establish a causal link between vitamin D deficiency and mortality in the patients.Waikato Hospital D respiratory specialist Dr Noel Karalus said it was not yet known whether giving patients vitamin D supplements after their admission to hospital with respiratory tract infections would alter outcomes."It may transpire that vitamin D helps us avoid infection rather than cure it once established."Cursons said the best source of vitamin D was sunlight as dietary sources such as fatty fish and cod liver oil did not contain enough vitamin D."There is still some controversy regarding the optimal daily allowance of vitamin D. How much we absorb through the skin depends on sun exposure, skin type and geographical latitude. M ori and Pacific Islanders absorb less because of their darker skin, and people in colder climates also have lower levels of vitamin D. "Pneumonia is the single largest cause of death in children worldwide, killing an estimated 1.6 million children under the age of five each year, according to the World Health Organization.The research findings are published in the journal Respirology, published by the Asian Pacific Society of Respirology, this month.

LOS ANGELES, April 12 (Xinhua) -- With the help of NASA Telescopes, astronomers have uncovered one of the youngest galaxies in the distant universe, with stars that formed 13.5 billion years ago, the Jet Propulsion Laboratory (JPL) announced on Tuesday.The finding addresses questions about when the first galaxies arose, and how the early universe evolved, JPL noted in a press release.Infrared data from both the Hubble Space Telescope and the post- coolant, or "warm," phase of NASA's Spitzer Space Telescope mission revealed that the galaxy's stars are quite mature, which means they must have formed when the universe was just a toddler, said JPL in Pasadena, Los Angeles.This challenges theories of how soon galaxies formed in the first years of the universe and could even help solve the mystery of how the hydrogen fog that filled the early universe was cleared, according to astronomers involved in the study.This galaxy is not the most distant ever observed, but it is one of the youngest to be observed with such clarity, JPL said.Normally, galaxies like this one are extremely faint and difficult to study, but, in this case, nature has provided the astronomers with a cosmic magnifying glass, JPL said.The galaxy's image is being magnified by the gravity of a massive cluster of galaxies parked in front of it, making it appear 11 times brighter. This phenomenon is called gravitational lensing."Without this big lens in space, we could not study galaxies this faint with currently available observing facilities," said Eiichi Egami of the University of Arizona in Tucson. "Thanks to nature, we have this great opportunity to see our universe as it was eons ago."The findings may help explain how the early universe became " reionized," according to JPL."Seeing a galaxy as it appeared near the beginning of the universe is an awe-inspiring feat enabled by innovative technology and the fortuitous effect of gravitational lensing," Jon Morse, NASA's Astrophysics Division director at the agency's headquarters in Washington, said in the release."Observations like this open a window across space and time, but more importantly, they inspire future work to one day peer at the stars that lit up the universe following the big bang."

WASHINGTON, April 6 (Xinhua) -- A study led by researchers at the University of Michigan (U-M) showed in animal studies that new cancer drug compounds they developed shrank tumors, with few side effects.The study, done in two mouse models of human cancer, looked at two compounds designed to activate a protein that kills cancer cells. The protein, p53, is inactivated in a significant number of human cancers. In some cases, it is because another protein, MDM2, binds to p53 and blocks its tumor suppresser function. This allows the tumor to grow unchecked. The new compounds block MDM2 from binding to p53, consequently activating p53."For the first time, we showed that activation of p53 by our highly potent and optimized MDM2 inhibitors can achieve complete tumor regression in a mouse model of human cancer," says lead study author Shaomeng Wang, director of the Cancer Drug Discovery Program at the U-M Comprehensive Cancer Center.Wang presented the study Wednesday at the American Association for Cancer Research 102nd annual meeting.Many traditional cancer drugs also activate p53 but they do so by causing DNA damage in both tumor cells and normal cells, causing side effects. These new MDM2 inhibitors activate p53 while avoiding the DNA damage common with other drugs. In this study, which was done in collaboration with Ascenta Therapeutics and Sanonfi-Aventis, researchers showed that these new drugs shrank tumors without significant side effects.Because p53 is involved in all types of human cancer, the new drug has potential to be used in multiple types of cancer. Further, the researchers also identified certain markers in tumors that predict which ones will be particularly sensitive to the MDM2 inhibitor, which would allow physicians to target the drug only to patients most likely to benefit.

来源：资阳报