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SAN DIEGO (KGTV) — In some of the most severe cases of COVID-19, doctors are finding it’s not the coronavirus making people critically ill.It’s their own immune system, and a San Diego-based biotech company thinks it has an answer.La Jolla-based INmune Bio announced Tuesday it has FDA approval to begin a Phase 2 clinical trial on its inflammation fighting drug, Quellor.In many of the sickest COVID patients, doctors have noticed their blood is filled with high levels of immune proteins called cytokines. Cytokines act as messengers between cells and the virus can cause them to go haywire, setting off what’s known as a cytokine storm.In a cytokine storm, the body’s immune system starts to attack its own cells and tissues rather than the virus. During the Spanish Flu of 1918, many of the deaths were caused by cytokine storms.“You need to control the cytokine storm to keep patients from getting sick,” said INmune Bio’s CEO Dr. R.J. Tesi.There are several different types of cytokines. A drug undergoing testing in a federal trial with remdesivir targets a cytokine called beta interferon.The San Diego biotech’s drug Quellor suppresses a very specific cytokine called soluble tumor necrosis factor, which Dr. Tesi calls “the master cytokine” because of its role in triggering other immune proteins.Dr. Tesi said this particular cytokine may contribute to another troubling issue with COVID-19: blood clotting.“When they write the history of COVID-19, the clots are going to be the bad guy,” Dr. Tesi said. “These blood clots go off everywhere and they gum up the works. They make it so the lungs can't work. They make it so the kidneys can't work. They make it so the heart is screwed up. Make it so you have strokes.”INmune Bio, which is publicly traded but has just six full-time employees, is hoping its drug can address both the blood clots and the inflammation.The company plans to enroll 366 hospitalized COVID-19 patients for a Phase 2 trial to see if intervention with Quellor can keep people off ventilators and out of the ICU. 2053

SAN DIEGO (KGTV) — It's no secret: exploring San Diego is a bit different amid county health orders and the COVID-19 pandemic. But there are still ways to explore safely! We're continuing our weekly look at fun around town with safety in mind.Here are four options for this weekend:Visit Old Town San Diego: While many of Old Town's smaller museums and shops remain closed, areas like the state park, Bazaar del Mundo, and nearby eateries are open for visitors. Businesses that have reopened are abiding by distancing, so guests can feel safe shopping in stores. The state park is also a great area to get some fresh air and distance. More infoCounty fair fun: The San Diego County Fair may be canceled this year, but the Del Mar Fairgrounds is continuing to highlight fair exhibits, foods, and more online and at the fairgrounds. Fair food vendors welcome guests Friday - Sunday throughout June for kettle corn, hot dogs, and more treats and the fair is hosting virtual exhibits showcasing student artwork, photography, and livestock shows. More infoHit the beach: San Diego County's beaches are open for laying out and relaxing, and parking lots, boardwalks, and piers have reopened. With warm temperatures lingering this week, it's the perfect time for a beach day. Just remember to wear a facial covering and practice distancing when near non-household members. More infoCheck out the San Diego Air and Space Museum: Balboa Park's first museum to reopen will be on Friday, as the San Diego Air and Space Museum welcomes guests with increased safety measures like stylus pens for hands-on exhibits, sanitation procedures, and distancing between guests. More info 1673

SAN DIEGO (KGTV) — Mardi Gras is right around the corner, which means San Diegans are getting ready to "laissez les bons temps rouler" (let the good times roll.)Several events this weekend will kick off the local festivities in San Diego. All of it culminating on March 5, known as "Fat Tuesday,"traditionally the last day of the Carnival season.Looking for Kings Cake as well? Try out this delicious recipe from San Diego Family Magazine!Here are some great events you won't want to miss out on:San Diego Mardi Gras Fat Tuesday Celebration When: March 1 - 2, March 5 Where: Gaslamp District Cost: Starts at Mardi Gras gets started early in San Diego's Gaslamp District with 20 parties over the weekend and then for one more night on Fat Tuesday. Tickets get guests access to more than 20 nightclubs, bars, and restaurants, an opening night and finale party, and food and drink specials around downtown.Gaslamp District Mardi Gras Big Easy Bites & Booze TourWhen: March 2Where: Gaslamp DistrictCost: Starting at Enjoy a taste of San Diego and Mardi Gras with 20 Mardi-Gras inspired plates, Carnival cocktails, an exclusive after party at a secret location, and more during the Gaslamp Mardi Grass Big Easy Bites and Booze Tour through downtown.2nd annual Blvd. Mardi Gras CrawlWhen: March 3Where: El Cajon Boulevard, North ParkCost: Tickets are free for - specialsA traveling party will take over North Park's El Cajon Boulevard, bringing guests across local breweries, bars, and restaurants for drink and food specials, led by the Euphoria Brass Band along the way! The final stop will be a party at the Lafayette Hotel for music, dancing, and the best-decorated “Mardi-Bra” contest.Mardi Gras 10K & 5KWhen: March 3Where: Rancho Bernardo Community ParkCost: - Celebrate Mardi Gras and enjoy a Carnival in the park in Rancho Bernardo at the inaugural Mardi Gras 10K & 5K. Hit the scenic trails around RB in colorful Mardi Gras gear and enjoy a finish line festival!Mardi Gras Party at House of BluesWhen: March 5Where: House of Blues San DiegoCost: No cover, open to publicHouse of Blues celebrate Mardi Gras with a party at its restaurant and Voodoo Room, featuring a special food and drink menu, circus and interactie entertainment, and live music by Madame Leroux & Krewe. 17th Annual Hillcrest Mardi GrasWhen: March 5Where: Hillcrest Pride FlagCost: - Hillcrest will host a neighborhood-wide party crawl through the area's best bars, clubs, and music venues. Themed party stops will greet guests with drink deals, collectible beads, giveaways, and live entertainment! 2613

SAN DIEGO (KGTV) — If you're riding the bus to "Flavortown," there's only one stop in San Diego.Celebrity chef Guy Fieri was spotted at Ocean Beach's Hodad's location alongside owner Shane Hardin, the son of late owner Mike "Bossman" Hardin, on Monday. Pictures from local photographer Jim Grant show the "Diners, Drive-Ins, and Dives" host mingling with the restaurant's crew and taking photos with fans.City of San Diego spokeswoman Alma Rife said the city had issued a "blanket permit," or filming throughout San Diego, for an untitled Food Network program from March 4-7. A Food Network spokesperson was not able to provide comment as to the nature of the filming.RELATED:Inventive eggs Benedict, dumpling soup highlight San Diego's foodie scene on YelpSeven San Diego burritos among the best in the U.S., ranking saysFieri is no stranger to the OB staple. He stopped by on past episodes of "Triple D," once in 2007 for the "Seaside Eats" episode and then again in 2013 for the episode, "All San Diego, All the Time."Hodad's has also been featured in other Food Network specials, including "Top 10 Burgers" and "With Bacon," the latter of which saw Fieri and other chefs dish on their favorite bacon eats.Fieri's kinship with the local burger joint inspired its own Hodad's burger: The Guido Burger, a pastrami-smothered burger with ketchup, pickles, swiss cheese, grilled onions, and spicy brown mustard.Monday, the chef posted a photo on Twitter of one fan's dedication to the delicious land which he coined: 1522

SAN DIEGO (KGTV) — Local officials say the county has been cleared to reopen more businesses ahead of the state, including gyms, hotels, bars, day camps, and museums.According to the county, the following businesses would be allowed to reopen no earlier than June 12, pending approval by local health officials:GymsHotelsBars/wineriesZoos and indoor museumsFamily entertainment facilities (bowling alleys, batting cages, etc.)Day campsCampgroundsPro sports without fansFilm and TV productionCard roomsSan Diego Supervisors sent a letter to Gov. Gavin Newsom last week requested the expanded reopenings.Friday, the state released new guidance on reopening sectors of the economy including the businesses listed above for variance counties, of which San Diego is included. The state's criteria for sectors can be found here."The following guidance should be implemented only with county health officer approval following their review of local epidemiological data including cases per 100,000 population, rate of test positivity, and local preparedness to support a health care surge, vulnerable populations, contact tracing and testing," the state's website reads.RELATED:California to let schools, gyms, bars reopen next weekSan Diego to reopen several shoreline parks, piers, boardwalksSan Diego Supervisors request state allow gyms, pools, theme parks to reopenThis week, San Diego County allowed sitting and relaxing on beaches to resume and announced that beach parking lots would reopen and beach activities will resume within household units on June 9.The City of San Diego also announced this week that several popular piers, boardwalks, and beach parks would reopen this month.As of Friday, San Diego County had reported 8,180 coronavirus cases and 294 deaths. About 1,397 people have been hospitalized with the virus. 1833

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