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WASHINGTON, Sept. 12 (Xinhua) -- An enzyme that appears to play a role in controlling the brain's response to nicotine and alcohol in mice might be a promising target for a drug that simultaneously would treat nicotine addiction and alcohol abuse in people, U.S. researchers find.Over the course of four weeks, mice genetically engineered to lack the gene for protein kinase C (PKC) epsilon consumed less of a nicotine-containing water solution than normal mice, and were less likely to return to a chamber in which they had been given nicotine. In contrast, normal mice steadily increased their consumption of nicotine solution while the mice lacking PKC epsilon did not.The study conducted by researchers at the Ernest Gallo Clinic and Research Center, affiliated with the University of California, San Francisco, appeared Monday in the online edition of the Proceedings of the National Academy of Sciences.In normal mice, as in humans, nicotine binds to a certain class of nicotinic receptors located on dopamine neurons, which causes dopamine to be released in the brain. Dopamine creates a feeling of enjoyment, and thus prompts a sense of reward. Researchers found that mice lacking PKC epsilon are deficient in these nicotinic receptors.The finding complements earlier research in which researchers found that mice genetically engineered to lack the PKC epsilon enzyme drank less alcohol than normal mice and were disinclined to return to a chamber in which they had been given alcohol."This could mean that these mice might not get the same sense of reward from nicotine or alcohol," said Gallo senior associate director and investigator Robert Messing. "The enzyme looks like it regulates the part of the reward system that involves these nicotinic receptors."The reward system is a complex of areas in the brain that affect craving for nicotine, alcohol and other addictive substances.The next step in the research, said Messing, would be to develop compounds that inhibit PKC epsilon. The ultimate goal, he added, would be medications that could be used "to take the edge off of addiction by helping people get over some of their reward craving."

SYDNEY, Aug. 2 (Xinhua) -- Australia's general practitioners ( GPs) will not back the idea of routine prostate cancer tests for men as young as 40 despite growing calls for regular screening, the nation's largest professional general practice organization said on Tuesday.Spokesman for the Royal Australian College of General Practitioners (RACGP), Professor Chris Del Mar said there was not enough solid evidence to suggest major benefits from routine screening and that current tests were unable to detect "nasty" and potentially deadly forms of prostate cancer from ones that will not cause any harm."The problem is you end up treating lots of people who don't need to be treated," Del Mar said, adding that treatment could leave men impotent and with incontinence problems."You will treat 20 times as many people than would have ever been bothered by it. We don't yet know that treating prostate cancer is better than not treating it. We are not sure it does any good and could be doing more harm," he said.On the other hand, Australia's urologists and pathologists both want men aged 40 and over who are worried about developing the disease to be offered tests.The Royal College of Pathologists (RCPA) on Tuesday released an official recommendation on routine screening for men aged 40 and over if they were concerned about prostate cancer.The pathologists argue that blood tests for prostate cancer in men under 50 can predict their future risk of developing the disease by measuring their prostate specific antigen levels (PSA).They say that men with high PSA levels for their age should be tested annually, while those PSA levels are below the average could be tested less frequently.Their call for more routine testing contrasts with recommendations for GPs, whose `Red Book' medical guide does not support regular screening.Instead, it suggests GPs should inform men aged 50-70 of the risks and benefits of screening and only test if the patient requests one.RACGP spokesman Del Mar, who co-wrote the RACGP's recommendations, said while the Red Book was being revised "we are not going to liberalize it".Prostate cancer is one of the most common forms of cancer in Australia.About 20,000 cases of prostate cancer are diagnosed each year, with 3,300 men dying.Given the debate around prostate cancer tests, the Royal College of Pathologists wants to work with GPs, urologists and other medical organizations to develop a consensus on how and when to test for the disease, in a similar way to how experts approach breast cancer."It would be a good outcome for prostate cancer if we worked towards developing more of an umbrella document which reflected consensus among different stakeholder organizations. ," RCPA President Paul McKenzie said.

BEIJING, May 30 (Xinhuanet) -- Chronic diseases, including heart disease, stroke, cancer, chronic respiratory diseases and diabetes, are the leading cause of mortality in China, representing 85 percent of all deaths, said a senior health official.Kong Lingzhi, deputy director of the disease prevention and control bureau under the Ministry of Health, made the remarks on Saturday at the Forum of Prevention and Control of Chronic Disease."China is facing a great challenge from chronic diseases, which has a serious impact on both the economy and society," said Kong.Each year, about 3.7 million people die before they reach 60 because of chronic diseases. There are currently 200 million hypertension patients and 90 million diabetics in China, official statistics show.To address the challenge, "the government is now drafting an inter-ministerial roadmap for chronic disease intervention, which will set targets, define responsibilities and distribute guidelines for the prevention and control of chronic diseases," she said.The initiative aims to strengthen national and global monitoring and surveillance; scale up the implementation of evidence-based measures to reduce risk factors, such as tobacco use, an unhealthy diet, physical inactivity and harmful alcohol use; and improve access to cost-effective healthcare to prevent complications, disabilities and premature death.But more importantly, the roadmap will help gain attention and support for preventing and controlling chronic diseases and place it high on government working agendas, Kong explained.The government has focused more on addressing instant health crises up to now and policy and funding support for chronic disease control and prevention was very limited, admitted Mao Qun'an, spokesman of the ministry.Given that chronic disease control requires a systematic approach, tasks such as public health education, training for medical workers (especially the grassroots ones) and policies encouraging doctors' involvement need to be carried out, he said.The ultimate goal is to prevent people from getting ill rather than treating diseases, he added.Lei Zhenglong, deputy director of the disease prevention and control bureau, said that to enhance the capacity of medical workers was now the top priority for the initiative.At present, effective disease prevention work usually contradicts the financial interests of clinical doctors, analysts said.A respiratory disease doctor surnamed He with the Peking University People's Hospital said that he came under pressure from the hospital authorities when the number of inpatients declined due to his efforts to inform his patients about chronic disease prevention.

BEIJING, June 27 (Xinhuanet) -- A "lean gene" that helps people keep slim was found closely related to diabetes and heart disease, according to a study pulished in Nature Genetics journal on Sunday.The scientists from Britain’s Medical Research Council Epidemiology Unit conducted the study.After comparing the genetic codes of more than 75,000 people, a gene called IRS1 was spotted as the decisive factor to lower the fat level in human body.But in further study, IRS1 was found putting people to a 20 percent higher risk of developing heart disease and type-2 diabetes.The study warned that people who appear slim and fit might be also at risk.But scientists suggest that the study results did not change the general message for most people."While this study pointed to genes as one factor in determining the risk of developing these conditions, it was important to remember that lifestyle factors like diet, exercise, cutting out smoking and maintaining a healthy weight also play a vital role in reducing the risk," said Ruth Loos, who led the study.

BEIJING, Aug. 12 (Xinhuanet) -- The risk of developing coronary heart disease is 25 percent higher for women smokers compared with men, according to a study published in the British medical journal "The Lancet".The authors say this could be due to the physiological differences between the sexes with cigarette smoke toxins having a more potent effect on women.The study by Dr Rachel R Huxley from the University of Minnesota and Dr Mark Woodward from Johns Hopkins University involved a meta-analysis of around four million individuals and 67,000 coronary heart disease events from 86 studies.The researchers found that the pooled adjusted female-to-male relative risk ratio (RRR) of smoking compared with not smoking for coronary heart disease (CHD) was 1.25 (25 percent) higher for women.This RRR increased by 2 percent for every additional year of follow-up, meaning that the longer a woman smokes, the higher her risk of developing CHD becomes compared with a man who has smoked the same length of time.The authors say, "The finding lends support to the idea of a pathophysiological basis for the sex difference. For example, women might extract a greater quantity of carcinogens and other toxic agents from the same number of cigarettes than men. This occurrence could explain why women who smoke have double the risk of lung cancer compared with their male counterparts."Worldwide, there are 1.1 billion smokers, of whom a fifth are women.According to the Tobacco Atlas, India, with around a crore female smokers, ranks third in the top 20 female smoking populations across the globe, only the U.S. with 2.3 crore female smokers and China with 1.3 crore female smokers, are worse off.

来源：资阳报