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BEIJING, Oct. 11 (Xinhuanet) -- An experimental drug that can remove amyloid plaques from the brains of Alzheimer's patients is being developed by Swiss Roche Holding AG in a small early-stage study, according to a report published in the Archives of Neurology on Monday.Researchers suspect the build-up of such plaques may be a cause of the memory robbing disease, although that theory has yet to be definitively proved. Gantenerumab, a biotech drug designed to bind to amyloid plaques in the brain and remove them, is being targeted at the early stages of Alzheimer's with the hope it can slow progression of the disease while patients are still able to function.The Phase I study of 16 Alzheimer's patients tested gantenerumab at two doses against a placebo over six months of treatment.The Roche drug led to a dose-dependent reduction of brain amyloid, while amyloid load increased in patients receiving a placebo, the report said.The next step will be to investigate whether removal of brain amyloid translates into clinical benefit for patients at doses of the experimental drug that are well tolerated and safe, the report said.Much larger trials and further study will be needed to fully understand how gantenerumab works and whether it can stave off Alzheimer's, said the report.Roche is approaching the disease far earlier because amyloid accumulates for 15 years before dementi.

WASHINGTON, Dec. 7 (Xinhua) -- Drugs that affect the levels of an important brain protein involved in learning and memory reverse cellular changes in the brain seen during aging, according to an animal study published Wednesday in the Journal of Neuroscience. The findings could one day aid in the development of new drugs that enhance cognitive function in older adults.Aging-related memory loss is associated with the gradual deterioration of the structure and function of synapses (the connections between brain cells) in brain regions critical to learning and memory, such as the hippocampus.Recent studies suggested that histone acetylation, a chemical process that controls whether genes are turned on, affects this process. Specifically, it affects brain cells' ability to alter the strength and structure of their connections for information storage, a process known as synaptic plasticity, which is a cellular signature of memory.In the current study, Cui-Wei Xie, of the University of California, Los Angeles, and colleagues found that compared with younger rats, hippocampi from older rats have less brain-derived neurotrophic factor (BDNF) -- a protein that promotes synaptic plasticity -- and less histone acetylation of the Bdnf gene. By treating the hippocampal tissue from older animals with a drug that increased histone acetylation, they were able to restore BDNF production and synaptic plasticity to levels found in younger animals."These findings shed light on why synapses become less efficient and more vulnerable to impairment during aging," said Xie, who led the study. "Such knowledge could help develop new drugs for cognitive aging and aging-related neurodegenerative diseases, such as Alzheimer's disease," she added.

SAN FRANCISCO, Oct. 27 (Xinhua) -- Hewlett-Packard(HP) on Thursday announced that it will keep its personal systems group ( PSG) and continue to sell personal computers."HP objectively evaluated the strategic, financial and operational impact of spinning off PSG. It's clear after our analysis that keeping PSG within HP is right for customers and partners, right for shareholders, and right for employees," Meg Whitman, HP president and chief executive officer, said in a statement.On Aug. 18, former CEO Leo Apotheker said HP was considering spin off the PC business, which drove shares of the company to plunge 20 percent the following day.HP then said its board of directors has authorized the exploration of strategic alternatives for the PSG, and it will consider a broad range of options that may include a full or partial separation of the PC business through a spin-off or other transaction.According to HP, the review so far revealed the depth of the integration of its PC division that has occurred across the company's key operations including supply chain and procurement.In addition, it indicated that the division has made significant contributions to HP's solutions portfolio and overall brand value."Finally, it also showed that the cost to recreate these in a standalone company outweighed any benefits of separation," HP said in a press release announcing the latest decision.HP is now the world's largest PC-maker with revenues of the PC division totaling 40.7 billion U.S. dollars for fiscal year 2010, according to figures from the company.A recent report from market research firm Gartner found that in the third quarter of 2011, HP's PC shipments grew 5.3 percent year- on-year, faster than the industry average of 3.2 percent, and its share in global PC market actually increased slightly to 17.7 percent.Though the PC division has a lower margin, the position and scale as the world's No. 1 PC-vendor gives HP advantage to negotiate with other suppliers and helps its other businesses, analysts said.The announcement to keep the PC unit is seen as the first major move of HP under new CEO Whitman, who took the job just over a month ago after replacing Apotheker on Sept. 22.

BEIJING, Jan. 6 (Xinhua) -- China's railways will carry 235 million passengers during the 40-day Spring Festival travel rush, up 6.1 percent year-on-year, the Ministry of Railways said Friday.A daily average of 5.88 million people will make trains trips from Jan. 8 to Feb. 16, the ministry said in a statement on its website.Economic hubs such as Beijing, Guangzhou, Shanghai and Hangzhou and the inland provinces of Sichuan, Hubei, Jiangxi, Anhui and Hunan will see the most activity during the period, as millions of rural migrant workers and students head home for family reunions, according to the statement.The ministry has arranged for extra trains in anticipation of the rush, the statement said, but added that "the conflict remains between passenger demand and railway capacity."Railway authorities have long been under pressure to increase capacity and improve ticketing services, as many citizens find it extremely hard to secure a single ticket during major holidays.The ministry has begun allowing customers to book their tickets online or by phone to ease the ordeal of buying tickets. However, website glitches and the huge demand have rendered the new ways ineffective to many ticket buyers.The Spring Festival, or the Chinese Lunar New Year, falls on Jan. 23.

CANBERRA, Dec. 9 (Xinhua) -- Scientists from Australia's University of New England on Friday said they had discovered the remarkably fossil isa metre-long arthropod with excellent vision called anomalocaris from Emu Bay Shale of South Australia.The scientists reported their finding on the anomalocaris in thescience journal Nature this week.It is reported that anomalocaris is a fearsome ancient predator that swam in the Cambrian oceans 500 million years ago. The researchers said the presence of anomalocaris would have driven the development of protective adaptations in prey animals. Such an escalatory 'arms race' would have seen, for instance, the evolution of such adaptations in prey as shells, camouflage and burrowing into sediments. "It has been unbelievably frustrating being able to see eyes like these at fossil sites like the Burgess Shale (in the Canadian Rocky Mountains), but not have any details. It is really refreshing to have our ideas about these animals confirmed at last, " comments Simon Conway Morris, a palaeontologist at the University of Cambridge, the United Kingdom.The research team was led by paleontologist Dr John Paterson, of the University of New England. He said the most surprising discovery of anomalocaris is the huge number of tiny hardened lenses in each eyes."When you consider that a modern housefly, for example, has about 3000 lenses, it's pretty impressive that an animal half a billion years old already has remarkable vision like this," Paterson said in statement."The fact that each eye in anomalocaris would have had over 16, 000 lenses means it would have very, very good resolution."Paterson said the acute vision of Anomalocaris gave it a distinct advantage over competing predators and prey, as many Cambrian animals either had poor vision or were completely blind. Its acute vision rivals or exceeds that of most living insects and was probably comparable to predatory dragonflies today.He said their findings support the idea that compound eyes evolved very early on in arthropod evolution, before the evolution of jointed legs or hardened exoskeletons.The research team hopes they can find the more fossil remains of Cambrian creatures in the Emu Bay Shale.