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OXON HILL, Md. (AP) — The finals of the Scripps National Spelling Bee have begun, with 50 kids on stage competing for more than ,000 in cash and prizes and a new, custom-designed trophy.This year's bee had the biggest field ever, with 562 spellers, more than half of whom got in through Scripps' wild-card program. Last year was the first time that wild cards were allowed into the bee, and the eventual champion was a wild card.Thursday's finalists include nine spellers who finished in at least a tie for 10th last year. The field will be narrowed to about a dozen spellers in the morning and early afternoon before the prime-time finals on ESPN.The last 14 champions and 19 of the past 23 have been Indian-American. 729

Patient care and safety are always our highest priorities, and we take this matter very seriously. We have conducted a thorough investigation and are working closely with the medical staff, patient care staff, and hospital leadership, as well as with the California Department of Public Health to ensure that an incident like this does not happen again. Consistent with patient privacy laws and hospital policy, we respect our patients’ privacy by not discussing the specifics of their care. 499

Pfizer announced Monday that its COVID-19 vaccine candidate has been 90% effective.In a press release, the company said that in Phase 3 trials, the vaccine has proven to promote a vaccine efficacy rate above 90% following the two-shot regimen.The Associated Press said that while Pfizer's announcement means the company is on track to file an application for emergency use authorization later this month, it does not mean a vaccine is "imminent" and more studies are needed.Pfizer's vaccine candidate began Phase 3 testing in the summer and is among a handful of vaccine candidates that could be distributed in the coming months pending FDA approval.Phase 3 trials consist of testing about 30,000 voluntary participants in a double-blind study — meaning half of those participating receive the vaccine, and half receive a placebo. Pfizer's vaccine requires two shots, which need to be taken 28 days apart.According to Pfizer, 90% of those who were tested for the vaccine had developed protection against the virus seven days following the second shot.Pfizer is already in the process of producing millions of doses of its vaccine candidate after the U.S. government agreed to pay .95 billion for 100 million doses of the vaccine, should it prove effective. If and when the FDA grants approval for the vaccine, it will be distributed to hospitals around the country by the U.S. military in an effort the Trump administration has dubbed "Operation Warp Speed.Even though hundreds of thousands of doses of the Pfizer vaccine will be ready for shipment if it is approved for emergency use, it will need to be rationed in the first months of its availability. According to a playbook for "Operation Warp Speed," essential health care workers and people in high-risk populations would have the first opportunity to get a COVID-19 vaccine. The rest of the general public will be able to get the vaccine as more doses become available later in 2021.Pfizer was one of a handful of companies that pledged in September not to distribute their vaccine under political pressure, and would only do so if it proved to be effective in large scale trials.Monday's announcement sent stock market futures through the roof, as investors eyed a return to economic normalcy should Pfizer's vaccine be given emergency approval in the coming days or weeks.President Donald Trump also celebrated the announcement in a tweet on Monday morning."STOCK MARKET UP BIG, VACCINE COMING SOON. REPORT 90% EFFECTIVE. SUCH GREAT NEWS!" Trump tweeted. 2524

Part of the cure for COVID-19 might be found in sharks dwelling deep in our oceans.“Everybody’s, ‘oh, there’s a hundred million being taken anyway, why are you worried about vaccine?’” said Stefanie Brendl of Shark Allies, a nonprofit for shark conservation.She says during the pandemic, more sharks are being harvested for squalene, an oil found in their livers and is often used to increase the effectiveness of vaccines.“The more products we come up with that require shark parts, the more we’re fueling this 100,000,000 sharks a year number,” she said.Brendl says many pharmaceutical companies are using shark squalene to produce a coronavirus vaccine and that if everyone in the world received two doses, 500,000 sharks would have to be slaughtered to meet the demand.“We need to look at this and we need to hold the vaccine companies accountable to test alternatives,” she said.One of the companies, Brendl, is calling out pharmaceutical giant GlaxoSmithKline, which plans on manufacturing 1 billion doses of a “pandemic vaccine” in 2021.While GSK says squalene pulled from shark livers is used in some of its vaccines, the company claims it’s also exploring squalene found in some plants.“One research team has tried to make in yeast so you could grow cultures of yeasts similar to fermenting beer,” said David Kroll, Ph.D., a professor of pharmacology at the University of Colorado, Anschutz Medical Campus.He says finding a cure for coronavirus will be the biggest vaccine undertaking in recent medical history.“The biggest concern is whether more sharks are going to have to be killed for this monumental global effort,” Kroll said.Shark experts believe this is a global challenge.“Many of the sharks that are being targeted are deep sea sharks and they’re found in open ocean environments that may not be protected,” said Chris Lowe, a professor of marine biology and director of the Shark Lab at California State University, Long Beach.He says tens of millions of sharks are already killed each year and some companies poach shark corpses for squalene to make numerous products ranging from vaccines to cosmetics.Lowe warns an increase in killings could impact our ecosystem.“Those animals play a very important role that could affect people on land,” he said.While the cost of a cure for COVID-19 is still unknown, Lowe says killing more sharks could mean extinction for several shark species. 2414

Playboy says it's leaving Facebook over the social network's handling of user data.The move was announced late Tuesday by Playboy's chief creative officer, Cooper Hefner, who is the son of the magazine's late founder, Hugh Hefner.He complained that Facebook's content guidelines and corporate policies contradict Playboy's values and that the platform "in our opinion continues to be sexually repressive.""Learning of the recent meddling in a free U.S. election further demonstrates another concern we have of how they handle users' data -- more than 25 million of which are Playboy fans -- making it clear to us that we must leave the platform," Cooper Hefner wrote on Twitter.Related: Elon Musk deletes Facebook accounts for Tesla and SpaceXFollowing his announcement, Playboy's main Facebook page was no longer available. Other official pages using the brand name, like Playboy Netherlands, were still accessible on the site. It wasn't clear whether Playboy has control over those pages.Facebook didn't immediately respond to a request for comment outside regular business hours.The company and its CEO, Mark Zuckerberg, have come under heavy criticism over revelations earlier this month that Cambridge Analytica, a data firm with ties to President Donald Trump's 2016 election campaign, reportedly accessed information from about 50 million Facebook users without their knowledge.The news has prompted some users to quit the platform. And Playboy isn't the first company to yank its presence.Last week, tech billionaire Elon Musk deleted the Facebook pages for his two main businesses, electric car maker Tesla and rocket startup SpaceX.Zuckerberg apologized last week for how the incident had been handled."This was a major breach of trust, and I'm really sorry that this happened," he told CNN.On Tuesday, Facebook sources told CNN that Zuckerberg has decided to testify before Congress on the issue within a matter of weeks.-- CNN's Artemis Moshtaghian and Rob McLean contributed to this report.The-CNN-Wire 2023