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SAN DIEGO (KGTV) — The Department of Defense has awarded a San Diego biotech company up to million to help develop a next-generation drug to fight COVID-19.Sorrento Therapeutics calls the drug a “rapid countermeasure” against the disease, one that might serve as a vaccine substitute in certain populations or a critical stopgap tool if the virus mutates.“With this, we have a new platform potentially that can respond very quickly to any type of emerging threat,” said CEO Dr. Henry Ji.Sorrento is trying to become the first company to develop an approved DNA-encoded monoclonal antibody treatment. The approach is similar to the experimental monoclonal antibody treatment used on President Trump, but Sorrento’s concept is a more advanced version that offers several benefits.Sorrento’s drug is designed to be used as either a treatment in infected patients or a fast-forming layer of defense in healthy people. The company said its solution should be cheaper and easier to deploy than existing monoclonal antibodies, while offering vaccine-like protective effects that last for several months rather than just two or three weeks.Antibodies are one of the body’s key defense mechanisms. They seek out pathogens and bind to them, marking the invader for destruction like ground troops marking an enemy base for an airstrike. In some cases, antibodies can even neutralize an invader themselves by blocking its method of entry into cells.Monoclonal antibodies are antibodies designed by scientists to neutralize a pathogen. They are hand-picked, genetically modified super antibodies that are cloned in labs.However, the process of growing these super soldiers in the lab is difficult, transporting them requires a cold chain, and as a result, monoclonal antibodies are among the most expensive drugs in the world.Instead of giving people an infusion of pre-made antibodies, Sorrento’s idea is to give people a shot of DNA that instructs some of their cells to churn out perfectly pre-designed antibodies.“It's much easier to make enough DNA to treat a large number of people than it is to make enough protein to treat a large number of people. That’s just a fact about manufacturing,” said Dr. Robert Allen, Sorrento’s chief scientific officer on the project.Dr. Allen said the company is hopeful the drug will induce cells to make protective antibodies for six months or more.This DNA approach to an antibody treatment has never been approved for any disease but other companies are working on their own versions of it. Another biotech with ties to San Diego, Inovio Pharmaceuticals, became the first company to test this approach in humans in 2019 for a drug targeting the Zika virus.Sorrento’s approach is similar to the way DNA vaccines work, but it cuts out intermediary steps and jumpstarts the production of antibodies, rather than leaving the production of antibodies up to the body’s immune system. The result is that protective antibodies can start circulating in days after injection rather than weeks, the company said.“What this is capable of doing is it bypasses the need for the immune system,” said Dr. Mark Brunswick, Sorrento’s senior vice president for regulatory affairs.The drug is unlikely to replace a vaccine in most situations because vaccines can produce other defense mechanisms like T-cells that work in conjunction with antibodies. But the drug might work better than a vaccine for the elderly and others with weakened immune systems who are unable to produce a robust number of antibodies on their own, Brunswick said.Still, the company still has a lot of pre-clinical work and testing to go. Sorrento is hoping to have the drug ready for human trials in four to six months.By then, vaccines from Pfizer and Moderna will likely be widely available, but Dr. Ji said the world needs to prepare for the possibility this virus will mutate.“When you vaccinate hundreds of millions, potentially billions of people, the virus is under tremendous evolution pressure,” he said. “It will escape. It’s guaranteed that the virus is going to mutate and escape all of the vaccines we’re trying to create.”If it does, he said Sorrento will be ready to rapidly deploy its DNA-based countermeasure. 4223

SAN DIEGO (KGTV) — The MCAS Miramar Air Show soars into town in September, bringing a spectacle of military and aerial might to San Diego.This year the show will honor the contributions and sacrifices of our nation's first responders, giving locals a moment to "reflect alongside our local police, fire, and emergency medical heroes and honor them for what they do every single day."The show will celebrate of armed forces with daily performances and demonstrations, exhibits, and static displays for guests to enjoy for free.WHENAir Show 2019 takes place Sept. 27 - 29 at MCAS Miramar. Tickets for seating to enjoy the festivities range from to 0. Entrance to the show is free.TRANSPORTATIONGeneral admission guests can enter MCAS Miramar via the North, East/Main, or West gates. Drivers will then be directed to parking areas. Grandstand and box seat ticket holders may use the same gates as well. Handicapped parking must be accessed through the West or North gates. Bus parking must use the West gate, as well. Bicyclists can enter through any gate, but must park thier bike near the flight live entry gate #2.Preferred parking pass holders can access parking from Harris Plant Rd. off Kearny Villa Rd. Chalet ticket holders must access parking through the South gate.This year, MCAS Miramar has set up a rideshare and taxi drop-off and pick-up location at the southeast corner of Elrod Ave. and Mitscher Way.WHAT YOU CAN/CANNOT BRINGThe airshow prohibits:Federally banned substances such as illicit narcotics — including marijuana and marijuana products or accessories;Weapons of any kind (regardless of permit), including but not limited to firearms, knives (including pocket knives and multi-tools), replica or toy weapons, pepper spray, mace, stun guns, and martial arts weapons;Outside alcoholic beverages;Pets, other than service animals;Glass containers;Bicycles, roller skates, roller blades, (kick and electric) scooters, skateboards, or hover boards;Personal drones (quad or hex copters) and they are not allowed to operate on federal property or airspace; orLasers or laser pointersTents or awnings, or tailgating will also be banned from the event. If guests are bringing anything, they must adhere to the following rules:Keys, makeup, feminine products, comb, phone, wallet, credit cards, etc. in pockets if not placed in clear bag;Binoculars and/or cameras;One large clear bag per person;Either a one-gallon Ziploc style bag, or commercially purchased clear bag – plus a small clutch for personal items. The larger clear bag must be made of clear PVC vinyl and easily searchable;Clear seat cushions and seat pads without pockets, zippers, compartments, or covers; orAn exception will be made for medically necessary coolers or ice chests after proper inspection.WHAT TO SEEFans routinely head over to the Air Show to check out the U.S. Navy Blue Angels demonstration squandron. The stars of the show have been flying since the 1940s and their maneuvers in F/A-18 Hornets are always a thrill. And don't forget about the squadron's traveling companion, a C-130 named "Fat Albert."The U.S. Army Golden Knights take to the skies but not inside aircraft. This parachute team fly to Earth at 120 mph, passing a baton and flying the American flag from 12,000 feet. And of course, they land right on target. The U.S. Navy Leap Frogs also soar through the air at death-defying speeds for fans.The Marine Air-Ground Task Force Demonstration is always a draw, demonstrating the coordinated use of air support, armor, artillery, and infrantry forces, simulating an all-out effort by the Marines.And, of course, there's the Aftershock Jet Firetruck — a 1940 For Fire Truck packed with twin Rolls-Royce Bristol Viper Jet Engines that total more than 24,000 horsepower.Plus, tons more of awesome demonstrations and events, and static displays on based to see throughout the show. A daily schedule of events can be found here. 3942

SAN DIEGO (KGTV) — The former home of San Diego Padres icon Tony Gwynn has finally found a buyer."Mr. Padre's" Poway home, that had since been foreclosed, was sold on Dec. 13 for ,429,500, according to Realtor.com. The two-acre residence was placed on the auction block in June starting at .2 million. The posted legal notice said that .5 million was still owed on the home.After the auction failed to find a new owner, the lender took control of the property.RELATED: Family of MLB legend Tony Gwynn settles tobacco lawsuitWhen the home remained empty, suspicious activity and reported squatters took up residence inside the estate. In January, the San Diego County Sheriff's Department said they had received nearly half a dozen reports about trespassers at the address over the past few weeks.Realtor celebrity reporter Erik Gunther said the steady price cuts on the property encouraged the new buyer to "take a swing" at the home."After a drawn-out debacle involving squatters and foreclosure, the former home of Hall of Famer Tony Gwynn finally has a new owner," Gunther wrote. "The bank whiffed with their initial price of .12 million, but a steady number of price cuts over the past few months finally encouraged a buyer to take a swing at rehabbing the baseball legend's home."The 7,370-square-foot home features seven bedrooms, 5.5 baths, living room with fireplace, a spacious kitchen and dining room, and its grounds include a basketball court and a pool with a spa. Bad investments by Gwynn caused the MLB legend to file for bankruptcy in 1987, which may have played a role in difficulties holding on to the property after his death from cancer in 2014. The Gwynn family had owned the residence since 1991 for the bank took ownership, according to Realtor. 1784

SAN DIEGO (KGTV) -- The Navy confirmed Thursday that the suspected Golden State Killer attended and graduated basic training at the Naval Training Center in San Diego.Officials say Joseph DeAngelo, 72, graduated from the training center after attending from October to December of 1964.DeAngelo also served aboard the Boston-class guided-missile cruiser USS Canberra (pictured below) during the Vietnam War.The Naval Training Center closed in 1997 and is now known as Liberty Station. The San Diego's District Attorney is also reexamining cold cases in San Diego that may have links to DeAngelo. TIMELINE: Major events in Golden State killer caseNew information Thursday also helps paint the picture of how authorities were able to catch the man accused of killing at least 12 people and raping at least 45 women.Prosecutors say authorities used genealogical sites to find a DNA match for DeAngelo, according to the Associated Press.Investigators compared the DNA collected from a crime scene of the Golden State killer to online genetic profiles and found a match: A relative of DeAngelo. Investigators didn't go into further detail such as which company they went through. DeAngelo is accused of committing the murders, rapes and more than 120 burglaries in the decade spanning between 1976 and 1986.RELATED: Suspect identified, arrested in East Area Rapist/Golden State Killer caseMost of the crimes happened near Sacramento and in the Bay Area.The Associated Press contributed to this report. 1544

SAN DIEGO (KGTV) — Target is rolling out more locations for customers to take advantage of drive-up shopping.Target's Drive Up service is expanding to more customers who place orders through the Target mobile app. The free service then delivers a customer's order to their car in under two minutes.Currently, the service is available in more than 1,100 Target locations, including in San Diego County:South Park (3030 Grape St., San Diego)Mission Valley (1288 Camino Del Rio N., San Diego)Lemon Grove (3424 College Ave., San Diego)National City Plaza Bonita (3060 Plaza Bonita Rd., National City)Grossmont (5500 Grossmont Center Dr., La Mesa)Chula Vista East (910 Eastlake Pkwy, Chula Vista)Rancho San Diego (2911 Jamacha Rd., El Cajon)El Cajon (250 Broadway, El Cajon)Mira Mesa (8251 Mira Mesa Blvd., San Diego)Santee (9846 Mission Gorge Rd., Santee)Poway (14823 Pomerado Rd., Poway)San Diego Del Sur (17170 Camino Del Sur, San Diego)Escondido South (280 E Via Rancho Pkwy, Escondido)Escondido (1280 Auto Park Way, Escondido)Vista South (3150 Business Park Dr., Vista)Vista (1751 University Dr., Vista)Oceanside (2255 S El Camino Real, Oceanside)Rancho California(29676 Rancho California Rd., Temecula)San Clemente (990 Avenida Vista Hermosa, San Clemente)Murrieta (41040 California Oaks Rd., Murrieta)“With this expansion of Drive Up, we’re continuing the momentum from our coast-to-coast roll out last year to bring even more guests their fastest Target Run yet,” Dawn Block, Target's senior vice president of digital, said in a release. “Guests love the ease and convenience of these parking lot pickups—in fact, it’s our top-rated fulfillment service.”Target's move comes as more retailers opt to offer curbside pick-up for orders, including the company's competitor Walmart, which also offers drive-up delivery for orders made the same day. 1854